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This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-11 and was most recently seen on 2026-06-11.
A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson–Crick base pair rules. The four main wobble base pairs are guanine–uracil (G–U), hypoxanthine–uracil (I–U), hypoxanthine–adenine (I–A), and hypoxanthine–cytosine (I–C). In order to maintain consistency of nucleic acid nomenclature, "I" is used for hypoxanthine because hypoxanthine is the nucleobase of inosine;
nomenclature otherwise follows the names of nucleobases and their corresponding nucleosides. The thermodynamic stability of a wobble base pair is comparable to that of a Watson–Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.
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