Why is "Vaccinia virus" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-24 16:24:39
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Vaccinia_virus entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-24 and was most recently seen on 2026-08-24.
Wikipedia Overview
The vaccinia virus is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, which encodes approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of approximately 5–10 fg. The vaccinia virus is the source of the modern smallpox vaccine, which the World Health Organization (WHO) used to eradicate smallpox in a global vaccination campaign in 1958–1977. Although smallpox no longer exists in the wild, vaccinia virus is still studied widely by scientists as a tool for gene therapy and genetic engineering.
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Trending Topic Today
Search Interest Perspective
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Oncolytic vaccinia virus JX-594 shows subtype-specific activity and candidate biomarkers in gastric cancer cell lines - Nature
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Vaccinia virus for lung cancer therapy: preclinical progress and prospects as a systemic immunotherapy platform - Frontiers
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Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery - Science | AAAS
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CD55-displaying oncolytic vaccinia virus treated metastatic cancers by evading the effect of host innate and adaptive humoral responses - ScienceDirect.com
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Vaccinia Virus Gene Acquisition through Nonhomologous Recombination - ASM Journals
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Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap - Nature
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Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study - The Lancet
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EMA Backs Broader Pediatric Use of Poxvirus Vaccine - Medscape
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Novel Treatment of a Vaccinia Virus Infection from an Occupational Needlestick — San Diego, California, 2019 - Centers for Disease Control and Prevention | CDC (.gov)
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Photos, videos, infographics - Vaccinia virus (Poxviruses) - RKI - Startseite
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Vaccinia virus MacGyvers a makeshift tool to repair its DNA, exposing a vulnerability - The Medical University of South Carolina
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Genome-wide analysis of vaccinia virus protein–protein interactions - PNAS
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Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genes | mBio - ASM Journals
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Laboratory-Acquired Vaccinia Virus Infection in a Recently Immunized Person — Massachusetts, 2013 - Centers for Disease Control and Prevention | CDC (.gov)
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Genetic ancestry and population structure of vaccinia virus - Nature
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Tiantan vaccinia virus-based vaccine with promising safety provides sustained protection against mpox in non-human primates - Nature
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Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes - Nature
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Rapid detection of vaccinia virus using biofunctionalized fiber-optic ball-tip biosensors - Nature
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Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice - Nature
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Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion - Nature
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A digital photography dataset for Vaccinia Virus plaque quantification using Deep Learning - Nature
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Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant - Nature
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A role for Z-DNA binding in vaccinia virus pathogenesis - PNAS
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Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines - PNAS
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Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus - Nature
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Report details vaccinia virus outbreak in 5 Chinese workers - CIDRAP
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An Update on the Known Host Range of the Brazilian Vaccinia Virus: An Outbreak in Buffalo Calves - Frontiers
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Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses - Nature
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Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy - Nature
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Protective Properties of Vaccinia Virus-Based Vaccines: Skin Scarification Promotes a Nonspecific Immune Response That Protects against Orthopoxvirus Disease - ASM Journals
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Vaccinia virus H7-protein is required for the organization of the viral scaffold protein into hexamers - Nature
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Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility - Nature
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Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression - PNAS
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Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection - Nature
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Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates - Nature
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mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge - Nature
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Vaccinia Virus Entry into Cells via a Low-pH-Dependent Endosomal Pathway - ASM Journals
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The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding - Nature
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Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis - PNAS
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Smallpox Vaccine - Centers for Disease Control and Prevention | CDC (.gov)
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Vaccinia Virus L1 Protein Is Required for Cell Entry and Membrane Fusion - ASM Journals
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Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus - Nature
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Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice - Frontiers
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An Overview of the Vaccinia Virus Infectome: a Survey of the Proteins of the Poxvirus-Infected Cell - ASM Journals
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Vaccinia Virus A26 and A27 Proteins Form a Stable Complex Tethered to Mature Virions by Association with the A17 Transmembrane Protein - ASM Journals
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Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells - Science | AAAS
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Cloning the vaccinia virus genome as a bacterial artificial chromosome in Escherichia coli and recovery of infectious virus in mammalian cells - PNAS
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Mechanism of vaccinia virus assembly in infected-cells - News-Medical
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Design and construction of a fast synthetic modified vaccinia virus Ankara reverse genetics system for advancing vaccine development - Frontiers
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Multi-omics analysis reveals the dynamic interplay between Vero host chromatin structure and function during vaccinia virus infection | Communications Biology - Nature
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Vaccinia Virus Extracellular Enveloped Virion Neutralization In Vitro and Protection In Vivo Depend on Complement - ASM Journals
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Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4+ T lymphocytes - PNAS
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Rabbitpox Virus and Vaccinia Virus Infection of Rabbits as a Model for Human Smallpox - ASM Journals
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Mapping vaccinia virus DNA replication origins at nucleotide level by deep sequencing - PNAS
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Association of the Vaccinia Virus A11 Protein with the Endoplasmic Reticulum and Crescent Precursors of Immature Virions - ASM Journals
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Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing - PNAS
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Host Cell Nuclear Proteins Are Recruited to Cytoplasmic Vaccinia Virus Replication Complexes - ASM Journals
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CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma - Nature
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Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line - Nature
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Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2 - Nature
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A Vaccine Based on a Modified Vaccinia Virus Ankara Vector Expressing Zika Virus Structural Proteins Controls Zika Virus Replication in Mice | Scientific Reports - Nature
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Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox - Nature
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Safety mechanism assisted by the repressor of tetracycline (SMART) vaccinia virus vectors for vaccines and therapeutics - PNAS
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Primary Human Macrophages Serve as Vehicles for Vaccinia Virus Replication and Dissemination - ASM Journals
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Monkeypox: some countries are protecting contacts with the smallpox vaccine, which uses humanity’s only domesticated virus - The Conversation
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Combined expression of miR-34a and Smac mediated by oncolytic vaccinia virus synergistically promote anti-tumor effects in Multiple Myeloma - Nature
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Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells In Vitro Ex Vivo and In Vivo - Nature
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A vital gene for modified vaccinia virus Ankara replication in human cells - PNAS
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Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge - PNAS
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Two Distinct Low-pH Steps Promote Entry of Vaccinia Virus - ASM Journals
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Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus - Nature
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A mechanism for induction of a hypoxic response by vaccinia virus - PNAS
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New strain of vaccinia virus can induce immunogenic cell death in tumors - Medical Xpress
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Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus - Nature
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Characterization of Ectromelia Virus Deficient in EVM036 , the Homolog of Vaccinia virus F13L , and Its Application for Rapid Generation of Recombinant Viruses - ASM Journals
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Trimerized S expressed by modified vaccinia virus Ankara (MVA) confers superior protection against lethal SARS-CoV-2 challenge in mice - ASM Journals
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Immunogenicity and Protection Against Influenza H7N3 in Mice by Modified Vaccinia Virus Ankara Vectors Expressing Influenza Virus Hemagglutinin or Neuraminidase - Nature
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Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8 - ASM Journals
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Effects of pre-existing orthopoxvirus-specific immunity on the performance of Modified Vaccinia virus Ankara-based influenza vaccines - Nature
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Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA) - Nature
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Laboratory-Acquired Vaccinia Virus Infection --- Virginia, 2008 - Centers for Disease Control and Prevention | CDC (.gov)
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Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV - Frontiers
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Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours - Nature
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Biological function of the vaccinia virus Z-DNA-binding protein E3L: Gene transactivation and antiapoptotic activity in HeLa cells - PNAS
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CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging - Nature
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Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus - PNAS
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A Vaccinia Virus-Driven Interplay between the MKK4/7-JNK1/2 Pathway and Cytoskeleton Reorganization - ASM Journals
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How Contagious Is Vaccinia? - The New England Journal of Medicine
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Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry - PNAS
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Recombinant vaccinia virus GLV-1h68 is a promising oncolytic vector in the treatment of cholangiocarcinoma - Nature
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Feds seize vaccinia virus vaccine used in 'stem cell' centers - CIDRAP
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Genes A27L and F13L as Genetic Markers for the Isolation of Recombinant Vaccinia Virus - Nature
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Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer - Wiley & Sons
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Combined anti-tumor efficacy of somatostatin fusion protein and vaccinia virus on tumor cells with high expression of somatostatin receptors - Nature
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Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1 - Nature
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How does the ISG15/ISGylation system modulate Vaccinia virus infection? - News-Medical
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Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus - News-Medical
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Vaccinia virus: New insights into the structure and function of the poxvirus prototype - Phys.org
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Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim - Nature
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Messenger RNA translation enhancement by immune evasion proteins: a comparative study between EKB (vaccinia virus) and NS1 (influenza A virus) - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.