Why is "Toxin-antitoxin system" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-05 03:01:12
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Toxin-antitoxin_system entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-05 and was most recently seen on 2026-06-05.
Wikipedia Overview
A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
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Trending Topic Today
Search Interest Perspective
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Comparative in silico analysis of vapBC3 toxin-antitoxin system in Mycobacterium Bovis and Mycobacterium tuberculosis - Nature
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Beyond plasmid addiction: the role of toxin–antitoxin systems in the selfish behavior of mobile genetic elements - ASM Journals
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Type I toxin-antitoxin systems and persister cell formation - Uppsala universitet
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Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny - Nature
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A peptide of a type I toxin−antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids - PNAS
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Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation - ASM Journals
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A quinolone N -oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system - Nature
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Gentamicin induction of the gonococcal hicAB toxin-antitoxin-encoding system and impact on gene expression influencing biofilm formation and in vivo fitness in a strain-specific manner - ASM Journals
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A toxin-antitoxin system provides phage defense via DNA damage and repair - Nature
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The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA - Nature
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An oxygen-sensitive toxin–antitoxin system - Nature
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A ParDE-family toxin antitoxin system in major resistance plasmids of Enterobacteriaceae confers antibiotic and heat tolerance - Nature
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Molecular stripping underpins derepression of a toxin–antitoxin system - Nature
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Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila - Nature
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The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity | Scientific Reports - Nature
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Biology and evolution of bacterial toxin–antitoxin systems - Nature
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Structural insight into the distinct regulatory mechanism of the HEPN–MNT toxin-antitoxin system in Legionella pneumophila - Nature
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Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis - Nature
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Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus - Nature
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Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism - Nature
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The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness - Nature
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VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response - Science | AAAS
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The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis - Nature
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de novo Synthesis of a Bacterial Toxin/Antitoxin System - Nature
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Newly discovered toxin-antitoxin system abundant in one-cell organisms - The Pennsylvania State University
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Toward the identification of a type I toxin-antitoxin system in the plasmid DNA of dairy Lactobacillus rhamnosus - Nature
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Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila - ASM Journals
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The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium - Nature
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A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS - Nature
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Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number - PNAS
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Mechanisms of neutralization of toxSAS from toxin–antitoxin modules - Nature
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Type II Toxin-Antitoxin Systems: Evolution and Revolutions - ASM Journals
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A toxin antitoxin system promotes the maintenance of the IncA/C-mobilizable Salmonella Genomic Island 1 - Nature
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MqsR toxin as a biotechnological tool for plant pathogen bacterial control - Nature
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Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses - Nature
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A regulatory role for Staphylococcus aureus toxin–antitoxin system PemIK - Nature
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Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis - Nature
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Mono- and multidomain defense toxins of the RelE/ParE superfamily - ASM Journals
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Chromosomal toxin-antitoxin systems in Pseudomonas putida are rather selfish than beneficial - Nature
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Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis - Nature
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system - ASM Journals
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Characterization of toxin-antitoxin systems from public sequencing data: A case study in Pseudomonas aeruginosa - Frontiers
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Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile - Nature
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hipBA toxin-antitoxin systems mediate persistence in Caulobacter crescentus - Nature
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Analysis of co-occurrence of type II toxin–antitoxin systems and antibiotic resistance determinants in Staphylococcus aureus - ASM Journals
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Relevance of charged and polar amino acids for functionality of membrane toxin TisB - Nature
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A minimal model for gene expression dynamics of bacterial type II toxin–antitoxin systems - Nature
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Plasmid-encoded toxin-antitoxin system directly controls plasmid replication: study - Phys.org
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Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system - Nature
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Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis - Nature
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Post-segregational Killing and Phage Inhibition Are Not Mediated by Cell Death Through Toxin/Antitoxin Systems - Frontiers
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Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems - Science | AAAS
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An Antisense RNA Fine-Tunes Gene Expression of the Type II MazEF Toxin-Antitoxin System - ASM Journals
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The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system - Wiley Online Library
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RES-Xre toxin-antitoxin locus knaAT maintains the stability of the virulence plasmid in Klebsiella pneumoniae - Taylor & Francis Online
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Identification and first characterization of DinJ-YafQ toxin-antitoxin systems in Lactobacillus species of biotechnological interest - Nature
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Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus - Nature
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Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis - Frontiers
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A YoeB toxin cleaves both RNA and DNA - Nature
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Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair - Nature
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Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems - Nature
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The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection - Nature
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Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488 - Nature
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Toxins-Antitoxins: Plasmid Maintenance, Programmed Cell Death, and Cell Cycle Arrest - Science | AAAS
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Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin - ASM Journals
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Control of lysogeny and antiphage defense by a prophage-encoded kinase-phosphatase module - Nature
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Molecular mechanisms of multiple toxin–antitoxin systems are coordinated to govern the persister phenotype - PNAS
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Chaperone addiction of toxin–antitoxin systems - Nature
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Thomas K. Wood Research Group - PSU Sites
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Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.