Why is "Topoisomerase II" trending?

Search Interest Perspective

• Complex mechanisms of topoisomerase II poisons revealed by whole-genome analysis - Nature
• Cotargeting DNA topoisomerase II enhances efficacy of RAS-targeted therapy in KRAS-mutant cancer models - JCI.org
• Nicotinonitrile based dual inhibitors of tubulin and topoisomerase II exhibit potent anticancer activity - Nature
• Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs - Wiley Online Library
• Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications - Rockefeller University Press
• Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast - PNAS
• Phytochemical profiling of Pleurospermum candollei flowers and stems reveals antioxidant constituents with topoisomerase II-targeted anticancer potential - Nature
• Chromatinization modulates topoisomerase II processivity - Nature
• Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection - Nature
• ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes - Nature
• Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II - Nature
• Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency - Nature
• Anticancer drugs targeting topoisomerase II for antifungal treatment - Nature
• Structural insights into fungal and human topoisomerase II with implications for in silico antifungal drug design - Nature
• Structural insights into the DNA topoisomerase II of the African swine fever virus - Nature
• Structural and functional insights into the T-even type bacteriophage topoisomerase II - Nature
• Nucleolar translocation of human DNA topoisomerase II by ATP depletion and its disruption by the RNA polymerase I inhibitor BMH-21 - Nature
• Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity - Nature
• Topoisomerase II and etoposide — a tangled tale - Nature
• Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes - Nature
• ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms - Nature
• Tumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma - Nature
• Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways - Nature
• DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II - Frontiers
• Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 - PNAS
• Author Correction: ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms - Nature
• DNA topoisomerase II inhibition potentiates osimertinib’s therapeutic efficacy in EGFR-mutant non–small cell lung cancer models - JCI.org
• New thiazole derivative as a potential anticancer and topoisomerase II inhibitor - Nature
• Substrate accessibility regulation of human TopIIa decatenation by cohesin - Nature
• Topoisomerase II inhibitor cures trypanosome infections - Nature
• Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models - Nature
• DNA topoisomerase II inhibition potentiates osimertinib’s therapeutic efficacy in EGFR-mutant non–small cell lung cancer models - JCI.org
• Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy - Frontiers
• Steroid-Modulated Transcription Synergistically Forms DNA Double-Strand Breaks With Topoisomerase II Inhibitor - Wiley Online Library
• TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription - Nature
• Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors - Nature
• Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate - Nature
• Isobenzofuranone derivative JVPH3, an inhibitor of L donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites - Nature
• Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity - Nature
• Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis - Frontiers
• Targeting DNA topoisomerase II in cancer chemotherapy - Nature
• PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis - Nature
• Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands - Nature
• DNA topoisomerase II and its growing repertoire of biological functions - Nature
• The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity - Nature
• Fitness Profiling Links Topoisomerase II Regulation of Centromeric Integrity to Doxorubicin Resistance in Fission Yeast - Nature
• Histone deacetylase interacts directly with DNA topoisomerase II - Nature
• Ciclopirox Olamine Exerts Tumor-Suppressor Effects via Topoisomerase II Alpha in Lung Adenocarcinoma - Frontiers
• Structural basis for allosteric regulation of Human Topoisomerase IIα - Nature
• Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells - Nature
• The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery - Nature
• Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast - PNAS
• Human topoisomerases and their roles in genome stability and organization - Nature
• Nitrogen‐containing heterocycles as topoisomerase II inhibitors for targeting cancer: Recent updates - Wiley Online Library
• DNA Topoisomerase II in Therapy-Related Acute Promyelocytic Leukemia - The New England Journal of Medicine
• Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells - Nature
• Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II - PLOS
• Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ | Scientific Reports - Nature
• Mitoxantrone, More than Just Another Topoisomerase II Poison - Evison - 2016 - Medicinal Research Reviews - Wiley Online Library
• Topoisomerase II-α Expression in Different Cell Cycle Phases in Fresh Human Breast Carcinomas - Nature
• Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats - Nature
• QSAR, Molecular Docking, and Pharmacokinetic Studies of 1,8-Naphthyridine Derivatives as Potential Anticancer Agents Targeting DNA Topoisomerase II - Science Partner Journals
• MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner - Nature
• Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90 | Scientific Reports - Nature
• Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly - Nature
• TDP2, TOP2, and SUMO: what is ZATT about? - Nature
• Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II - Nature
• Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain - Nature
• The Amazing Topoisomerase Enzyme: New Molecular Machine Animation from Discovery Institute - Science and Culture Today