Why is "Toll-like receptor" trending?

Search Interest Perspective

• Overweight and obesity induce Toll-like receptor 2-induced Type I IFN signaling - Nature
• Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target - Frontiers
• Chemerin Activation of Toll‐Like Receptor 4 Drives Mineralocorticoid Receptor–Mediated Aortic Valve Remodeling in Chronic Kidney Disease - American Heart Association Journals
• Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial - The Lancet
• LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity - Nature
• Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration - Frontiers
• The Toll-like receptor 1/2 ligand Pam3Cys inhibits memory impairment after traumatic brain injury in male and female rats - Nature
• The interplay between oncolytic viruses, Toll-like receptor signaling, and chemotherapy in overcoming tumor immune tolerance - Frontiers
• Toll-like Receptor 1 single nucleotide polymorphism is associated with impaired innate immune tolerance and dysregulated inflammatory responses to Borrelia burgdorferi in Lyme disease - Frontiers
• Assembly and localization of Toll-like receptor signalling complexes - Nature
• Toll-Like Receptor Signaling Pathways - Frontiers
• Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs - Nature
• Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity - Frontiers
• Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development - Nature
• The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome - Frontiers
• Molecular definition of the endogenous Toll-like receptor signalling pathways - Nature
• Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis - Frontiers
• Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics - Nature
• Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions - Frontiers
• The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling - Nature
• Toll-like Receptor 4 Polymorphisms and Atherogenesis - NEJM
• Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling - Nature
• Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function - Nature
• Toll-like receptor 9 antagonizes antibody affinity maturation - Nature
• A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway - science.org
• Comparative network-based analysis of toll-like receptor agonist, L-pampo signaling pathways in immune and cancer cells - Nature
• Molecular characteristics and therapeutic implications of Toll-like receptor signaling pathway in melanoma - Nature
• Protein disulfide isomerase integrates toll-like receptor 4 and P2X7 receptor signaling pathways during lipopolysaccharide-induced neuroinflammation | Scientific Reports - Nature
• Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2 - science.org
• Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions | Communications Biology - Nature
• The tRNAVal half: A strong endogenous Toll-like receptor 7 ligand with a 5′-terminal universal sequence signature - pnas.org
• Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies - Frontiers
• Toll-like receptor signalling - Nature
• Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice - American Physiological Society Journal
• Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression | Nature Immunology - Nature
• Cooperation of Toll-like receptor signals in innate immune defence - Nature
• Integrative multi-omics analysis reveals the role of toll-like receptor signaling in pancreatic cancer - Nature
• Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists - Nature
• Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5 - science.org
• Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis - pnas.org
• Toll-like receptor 4 modulates the cochlear immune response to acoustic injury - Nature
• An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling - Nature
• Toll-like receptor-mediated innate immunity orchestrates adaptive immune responses in HBV infection - Frontiers
• Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients - Nature
• Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection - ASM Journals
• The emerging role of Toll-like receptor 4 in myocardial inflammation - Nature
• Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies - Neurology® Journals
• Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer - Nature
• Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients - Nature
• Subverting Toll-Like Receptor Signaling by Bacterial Pathogens - Frontiers
• Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria - pnas.org
• Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia - Journal of Neuroscience
• Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis - Nature
• Porcine B Cell Subset Responses to Toll-like Receptor Ligands - Frontiers
• Signatures of balancing selection in toll-like receptor (TLRs) genes – novel insights from a free-living rodent - Nature
• A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria - science.org
• A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species - Frontiers
• Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen - Nature
• Toll‐like receptor expression during inflammatory processes in human diseases - Wiley Online Library
• Evolutionary redesign of the Atlantic cod ( Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions - Nature
• Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells - Nature
• Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes - Nature
• Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice - American Heart Association Journals
• Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals - Frontiers
• Toll-like receptor pathway evolution in deuterostomes - pnas.org
• Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM - pnas.org
• Toll-Like Receptor Signaling Pathways - science.org
• Multiple Roles of Toll-Like Receptor 4 in Colorectal Cancer - Frontiers
• Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6 - science.org
• Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro - Nature
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway - science.org
• A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity - pnas.org
• Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases - Nature
• Toll-like receptor 4 inhibition prevents autoimmune diabetes in NOD mice - Nature
• Neutrophil elastase binds at the central domain of extracellular Toll-like receptor 4: AI prediction, docking, and validation in disease model - Nature
• The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes - Frontiers
• Toll-Like Receptor 9-Dependent Immune Activation by Unmethylated CpG Motifs in Aspergillus fumigatus DNA - ASM Journals
• Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis - science.org
• Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine - Journal of Neuroscience
• Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury - Nature
• Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 - Nature
• Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers - Nature
• TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β - Nature
• Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor - Nature
• Evasion of Toll-like receptor 5 by flagellated bacteria - pnas.org
• Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation - Nature
• TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis - Nature
• Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists - Frontiers
• Toll-like receptor response to Zika virus infection: progress toward infection control - Nature
• NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A - Nature
• Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling - Nature
• S100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps | Scientific Reports - Nature
• Toll-Like Receptor-4 Modulation for Cancer Immunotherapy - Frontiers
• The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor - Nature
• Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice - Journal of Neuroscience
• A Toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy - ScienceDirect.com
• Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages - pnas.org
• Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells | Journal of Experimental Medicine - Rockefeller University Press
• The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype - science.org
• Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants - Nature