Why is "Thymidine" trending?

Search Interest Perspective

• Biomarker Guides Treatment Sequencing Predicts Outcomes in BRAF-Mutated Metastatic Melanoma - The ASCO Post
• Effect of tipiracil hydrochloride, thymidine phosphorylase inhibitor, on the ischemia/reperfusion injury of brain tissue in rats - Nature
• Re-evaluation of bovine herpesvirus 4 genotyping based on the thymidine kinase gene - ASM Journals
• Understanding Thymidine Kinase 2 Deficiency Before Disease-Modifying Therapy - NeurologyLive
• UCB wins CHMP favour for first thymidine kinase 2 deficiency treatment - European Pharmaceutical Review
• UCB Announces Publication of Data in Brain Communications Demonstrating Positive Impact of KYGEVVI® (doxecitine and doxribtimine) in Patients with Thymidine Kinase 2 Deficiency (TK2d) - PR Newswire
• The hidden impact of Thymidine Kinase 2 Deficiency - UCB
• Front. Immunology: Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development - afludiary.blogspot.com
• FDA Approves KYGEVVI® (doxecitine and doxribtimine), the First and Only Treatment for Adults and Children Living with Thymidine Kinase 2 deficiency (TK2d), a Rare and Devastating Mitochondrial Disease - mda.org
• FDA Approves Kygevvi, First Treatment for Thymidine Kinase 2 Deficiency - HCPLive
• UCB’s Kygevvi receives positive CHMP opinion for thymidine kinase 2 deficiency - pmlive.com
• Kygevvi: FDA Approves First Oral Treatment for Thymidine Kinase 2 Deficiency (TK2d) - WebMD
• EMA Recommends Kygevvi for Rare Thymidine Kinase 2 Deficiency Treatment - PharmTech.com
• Green silver nanoparticles of Khaya senegalensis as dual inhibitors of viral thymidine kinase and 3 C protease: metabolomics, and computational insights - Nature
• The FDA approves a treatment co-created at Vall d’Hebron for a rare muscle disease - Vall d'Hebron Barcelona Hospital Campus
• U.S. FDA approves KYGEVVI™ (doxecitine and doxribtimine), the first and only treatment for adults and children living with thymidine kinase 2 deficiency (TK2d) - PR Newswire
• Doxecitine/Doxribitine Approval Redefines Care in Thymidine Kinase 2 Deficiency: Fabian Somers, PhD - NeurologyLive
• FDA Approves Doxecitine and Doxribtimine Combination Therapy as First Treatment for Thymidine Kinase 2 Deficiency - NeurologyLive
• Results published in Neurology highlight a 95% reduction in risk of death with pyrimidine nucleos(t)ide therapy in patients with thymidine kinase 2 deficiency (TK2d) - PR Newswire
• NeuroVoices: Fabian Somers, PhD, on the First Approved Drug for Thymidine Kinase 2 Deficiency - NeurologyLive
• Thymidine nucleotide metabolism controls human telomere length - Nature
• Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency - Nature
• FDA approves 1st drug for thymidine kinase 2 deficiency - The Pharma Letter
• Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancer | Scientific Reports - Nature
• Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction - Nature
• First Drug Approved for Thymidine Kinase 2 Deficiency - SISMED - Società Italiana Scienze Mediche
• Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain - Nature
• Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells - Nature
• Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer - Nature
• ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth - Nature
• Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials - Frontiers
• Optimization of q Value for Sensitive Detection of Uridine and Thymidine Nucleosides by MS3 - ACS Publications
• New data on investigational therapy for thymidine kinase 2 deficiency presented at Muscular Dystrophy Association (MDA) 2025 Conference - PR Newswire
• Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study | Scientific Reports - Nature
• Cachexia and efficiency of trifluridine/thymidine phosphorylase inhibitor + bevacizumab in metastatic colorectal cancer - Nature
• Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level - Nature
• H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and Fate - jneurosci.org
• Pearls & Oy-sters: Case Report of a Patient With Adult-Onset Thymidine Kinase 2 Gene Deficiency - Neurology® Journals
• Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses - ASM Journals
• Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases - pnas.org
• Correction: Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect - Nature
• Renal impairment as a risk factor for chemotherapy induced neutropenia in the treatment of trifluridine/thymidine phosphorylase inhibitor plus bevacizumab - Nature
• Thymidine Kinase 2 Deficiency (TK2d) - WebMD
• Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming - Frontiers
• Thymidine-Dependent Small-Colony Variants of Staphylococcus aureus Exhibit Gross Morphological and Ultrastructural Changes Consistent with Impaired Cell Separation - ASM Journals
• A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography - pnas.org
• A Human-Derived Reporter Gene for Noninvasive Imaging in Humans: Mitochondrial Thymidine Kinase Type 2 - Journal of Nuclear Medicine
• Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials - Nature
• Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors - pnas.org
• Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase - Nature
• Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus - Nature
• Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice - American Heart Association Journals
• Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity - Nature
• Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction - American Heart Association Journals
• HSV-1 0∆NLS vaccine elicits a robust B lymphocyte response and preserves vision without HSV-1 glycoprotein M or thymidine kinase recognition - Nature
• Insights Into Cellular Regulation of Chromosome “Caps” - niddk.nih.gov
• Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling - Nature
• Patient Perspectives on Living with an Ultra-Rare Mitochondrial Disease: Thymidine Kinase 2 Deficiency (TK2d) - NeurologyLive
• Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency - Wiley Online Library
• Targeting thymidine phosphorylase alleviates resistance to dendritic cell immunotherapy in colorectal cancer and promotes antitumor immunity - Frontiers
• Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors - Nature
• A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma - Frontiers
• Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil - Nature
• Standardization of CFSE and Ki-67 based lymphocyte proliferation assays in the absence of thymidine-based methods among children with nephrotic syndrome in south India: A pilot study - medRxiv
• Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity - Nature
• Characterization of an immuno ‘stealth’ derivative of the herpes simplex virus thymidine-kinase gene - Nature
• H-FMAU in Proliferating and Nonproliferating Human Tumor Cells - Journal of Nuclear Medicine
• Decomposition of Thymidine by Low‐Energy Electrons: Implications for the Molecular Mechanisms of Single‐Strand Breaks in DNA - Wiley Online Library
• A novel thymidine phosphorylase mutation in a family with Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): Molecular docking, dynamic simulation and computational investigations - Wiley Online Library
• Suicide genes: monitoring cells in patients with a safety switch - Frontiers
• Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation - Nature
• Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes - Wiley & Sons
• Thymidine kinase 1 – A prognostic and diagnostic indicator in ALL and AML patients - Nature
• Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination - Nature
• RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis - jneurosci.org
• Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy - pnas.org
• Design, synthesis, molecular docking, and biological evaluation of coumarin-thymidine analogs as potent anti-TB agents - Wiley Online Library
• AR-42 inhibited pancreatic cancer cell growth and arrested cells at the G2/M phase. - PLOS
• The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice - Cambridge University Press & Assessment
• ) affects thymidine incorporation in human liver cancer cells - Nature
• Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery - Nature
• Microglia used as vehicles for both inducible thymidine kinase gene therapy and MRI contrast agents for glioma therapy - Nature
• Is Thymidine Glycol Containing DNA a Substrate of E. coli DNA Mismatch Repair System? - PLOS
• Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells - Nature
• Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography - Nature
• Decomposition of Thymidine by Low‐Energy Electrons: Implications for the Molecular Mechanisms of Single‐Strand Breaks in DNA - Wiley Online Library
• The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells - Nature
• Weapon of bone destruction identified - Science News
• PET imaging of herpes simplex virus type 1 thymidine kinase ( HSV1-tk ) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [ - Nature
• Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression - pnas.org
• Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine - pnas.org
• ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation - pnas.org
• Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase - Nature
• Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines - Nature
• Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene - Nature