Why is "Thioester" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-05-19 11:03:02
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Thioester entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-19 and was most recently seen on 2026-05-19.
Wikipedia Overview
In organic chemistry, thioesters are organosulfur compounds with the molecular structure R−C(=O)−S−R'. They are analogous to carboxylate esters with the sulfur in the thioester replacing oxygen in the carboxylate ester, as implied by the thio- prefix. They are the product of esterification of a carboxylic acid with a thiol. In biochemistry, the best-known thioesters are derivatives of coenzyme A, e.g., acetyl-CoA. The R and R' represent organyl groups, or H in the case of R.
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Search Interest Perspective
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Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water - Nature
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Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases - Wiley Online Library
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Thioester Ligation with AAHO Peptides - ACS Publications
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Thioesters could explain how proteins first formed on early Earth - Chemistry World
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Experiment sheds light on the origin of life, supporting the existence of a ‘thioester world’ before living beings - EL PAÍS English
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Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer - Nature
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Antioxidant and Degradable Poly(Squaryl Thioester) Networks - Wiley Online Library
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Scientists recreate life’s first step: Linking amino acids to RNA - ScienceDaily
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We may have solved a major part of the puzzle of how life got started - BBC Science Focus Magazine
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Catalytic acyloin-type heterocoupling of thioesters via a putative cobalt siloxycarbene - Nature
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How RNA helped build life’s first proteins - C&EN
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S‐Methyl Thioester Formation Uncovers Early Biosynthetic Steps of Yatakemycin - Wiley Online Library
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Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer - Nature
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Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling - Nature
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Thioester synthesis through geoelectrochemical CO2 fixation on Ni sulfides | Communications Chemistry - Nature
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Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates - Nature
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Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units - Nature
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An enzyme for high-yield, ATP-driven C-terminal thioester generation - Nature
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Thioesters provide a plausible prebiotic path to proto-peptides - Nature
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Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification - Nature
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Protocells by spontaneous reaction of cysteine with short-chain thioesters - Nature
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Prebiotic formation of thioesters via cyclic anhydrides as a key step in the emergence of metabolism - Nature
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An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules - Nature
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A Formal 1,2-Stevens Rearrangement of Thioester Ylides as a Single-Atom Molecular Editing Tool - ACS Publications
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Selective Activation of Peptide-Thioester Precursors for Templated Native Chemical Ligations - Wiley Online Library
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Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis - Nature
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Post-translational activation of the C-terminus of polypeptides for the synthesis of peptide thioesters and peptide thioester surrogates - Frontiers
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Scientists Make Breakthrough in Solving the Mystery of Life’s Origin - 404 Media
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Scientists uncover ‘missing link’ in life’s origin chemistry - Interesting Engineering
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Mechanistic Studies on Bromocyclization of Unsaturated Thioester by Density Functional Theory and Experiment - ACS Publications
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Palladium-Catalyzed Thiocarbonylation of Aryl Iodides with S-Aryl Thioformates via Thioester Transfer - ACS Publications
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Origins of Life Decoded? Researchers Unravel How RNA and Amino Acids May Have First Combined - The Debrief
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Degradable, Ultraviolet-Crosslinked Pressure-Sensitive Adhesives Made from Thioester-Functional Acrylate Copolymers - Wiley Online Library
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Thioester deprotection using a biomimetic NCL approach - Frontiers
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Ring-opening polymerization of six-membered cyclic hybrid dimers composed of an oxoester and thioester - Nature
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Enhancing the industrial relevance of alcohol dehydrogenase enzymes by exploiting their 'hidden reactivity' - Phys.org
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Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer - Nature
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Recyclable Polythioesters and Poly(thioester-co-peptoid)s via Ring-Opening Cascade Polymerization of Amino Acid N -Carboxyanhydrides - Wiley Online Library
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Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium - Nature
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Protein-pyridinol thioester precursor for biosynthesis of the organometallic acyl-iron ligand in [Fe]-hydrogenase cofactor - Nature
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Cross-linked degradable poly(β-thioester) networks via amine-catalyzed thiol-ene click polymerization - ScienceDirect.com
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An Elegant Method of One-Pot Ligation-Desulfurization for High-Yielding Chemical Protein Synthesis - Wiley Publishing
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Peptide Thioesters for Native Chemical Ligation - ChemistryViews
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Leveraging the Knorr Pyrazole Synthesis for the Facile Generation of Thioester Surrogates for use in Native Chemical Ligation - Wiley Online Library
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Photochemical Synthesis of Thioesters from Aryl Halides and Carboxylic Acids - Wiley Online Library
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Convenient Synthesis of Thioester-Substituted Oxindoles by Palladium-Catalyzed Thiocarbonylative Cyclization with Sulfonyl Chlorides as the Sulfur Source - Wiley Online Library
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Active site remodelling accompanies thioester bond formation in the SUMO E1 - Nature
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Photochemical Synthesis of Thioesters from Aryl Halides and Carboxylic Acids - Wiley Online Library
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Enzyme database promises to help engineers, biochemists and biologists - University of Nevada, Reno
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Encouraging Solution to the Problem of Synthesizing Protein α‐Thioester - Liu - 2024 - Chinese Journal of Chemistry - Wiley Online Library
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Exploring chemoselective S -to- N acyl transfer reactions in synthesis and chemical biology - Nature
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Repetitive Thiazolidine Deprotection Using a Thioester‐Compatible Aldehyde Scavenger for One‐Pot Multiple Peptide Ligation** - Wiley Online Library
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Organocatalytic Enantioselective Synthesis of Nitrocyclopropanes Bearing a Thioester Group and Three Stereogenic Centers - Wiley Publishing
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Structural basis for transthiolation intermediates in the ubiquitin pathway - Nature
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A Synthetic Approach to a Peptide α‐Thioester from an Unprotected Peptide through Cleavage and Activation of a Specific Peptide Bond by N‐Acetylguanidine - Wiley Online Library
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Nickel-Catalyzed Cross-Coupling of Aziridines with Thioesters toward Atom-Economic Synthesis of β-Sulfanyl Amides - ACS Publications
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Remoldable, Recyclable, and Repairable Thiol-Thioester Polymer Networks - University of Colorado Boulder
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Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation - Nature
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A New Architecture for DNA-Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation - Wiley Online Library
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Formation of thioesters by dehydrogenative coupling of thiols and alcohols with H - Nature
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An Efficient Fmoc‐SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation - Wiley Online Library
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The use of ene adducts to study and engineer enoyl-thioester reductases - Nature
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A strategic Ser/Cys exchange in the catalytic triad unlocks an acyltransferase-mediated synthesis of thioesters and tertiary amides - Nature
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Fast Protein Modification in the Nanomolar Concentration Range Using an Oxalyl Amide as Latent Thioester - Wiley Online Library
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Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity - Nature
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Athermal, Chemically Triggered Release of RNA from Thioester Nucleic Acids - Wiley Online Library
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Thioester‐Assisted Sortase‐A‐Mediated Ligation - Zuo - 2022 - Angewandte Chemie International Edition - Wiley Online Library
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The Abiotic Chemistry of Thiolated Acetate Derivatives and the Origin of Life | Scientific Reports - Nature
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Bistable and photoswitchable states of matter - Nature
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Accessing Therapeutically-Relevant Multifunctional Antisense Oligonucleotide Conjugates Using Native Chemical Ligation - Wiley Online Library
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Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability - Nature
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Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups - Wiley Online Library
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Peptide o‐Aminoanilides as Crypto‐Thioesters for Protein Chemical Synthesis - Wiley Online Library
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Structural transitions of complement component C3 and its activation products - PNAS
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Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase - Nature
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Light‐Driven Vitamin B12‐Catalysed Generation of Acyl Radicals from 2‐S‐Pyridyl Thioesters - Wiley Publishing
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A novel function for transglutaminase 1: Attachment of long-chain ω-hydroxyceramides to involucrin by ester bond formation - PNAS
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The Conversion of Nickel-Bound CO into an Acetyl Thioester: Organometallic Chemistry Relevant to the Acetyl Coenzyme A Synthase Active Site - Wiley Online Library
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Enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid - Science | AAAS
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Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion - Nature
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A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity - Wiley Online Library
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A way to thioacetate esters compatible with non-oxidative prebiotic conditions - Nature
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Biodegradability of unsaturated poly(ester-thioether)s synthesized by thiol-yne reactions - Nature
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Stereoselective Metal-Free Synthesis of β-Amino Thioesters with Tertiary and Quaternary Stereogenic Centers - Wiley Online Library
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Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI - Nature
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Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 - Springer Nature Link
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New scientific discovery reveals the origin of life on Earth - The Brighter Side of News
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A Reaction of Triazoles with Thioesters to Produce β-Sulfanyl Enamides by Insertion of an Enamine Moiety into the Sulfur–Carbonyl Bond - Wiley Online Library
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New study shows how complex metabolism may have self-assembled from simple precursors - titech.ac.jp
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Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α - Nature
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9‐Fluorenylmethoxycarbonyl‐Based Solid‐Phase Synthesis of Peptide α‐Thioesters - Wiley Online Library
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Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase - PNAS
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Thionoester - doccheck.com
Why This Topic Is Trending
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