Why is "Synaptic pruning" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-12 18:00:55
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Synaptic_pruning entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-12 and was most recently seen on 2026-05-12.
Wikipedia Overview
Synaptic pruning is the process of synapse elimination or weakening. Though it occurs throughout the lifespan of a mammal, the most active period of synaptic pruning in the development of the nervous system occurs between early childhood and the onset of puberty in many mammals, including humans. Pruning starts near the time of birth and continues into one's late 20s. During elimination of a synapse, the axon withdraws or dies off, and the dendrite decays and dies off. Synaptic pruning was traditionally considered to be complete by the time of sexual maturation, but magnetic resonance imaging studies have discounted this idea.
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Trending Topic Today
Search Interest Perspective
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Microglial CR3-mediated synaptic pruning in the dmPFC promotes the generation and maintenance of chronic muscle pain via glutamatergic dysfunction | Experimental & Molecular Medicine - Nature
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Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations - Frontiers
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New synaptic formation in adolescence challenges conventional views of brain development - Medical Xpress
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It's More Than Mom Brain—It's Synaptic Pruning - PureWow
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Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits - Nature
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New Brain Discovery Challenges Long-Held Theory of Teenage Brain Development - SciTechDaily
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Cognitive Control and Neural Activity during Human Development: Evidence for Synaptic Pruning - Journal of Neuroscience
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New synaptic formation in adolescence challenges conventional views of brain development - EurekAlert!
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Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning - Wiley & Sons
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Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine - Rockefeller University Press
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How synaptic pruning shapes neural wiring during development and, possibly, in disease - PNAS
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development - Science | AAAS
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Video catches microglia in the act of synaptic pruning - The Transmitter
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Are Similar Processes at Work in Both Brain Development and Cognitive Decline? - Simons Foundation
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Study links impaired synaptic pruning to autism - News-Medical
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Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy - Nature
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Visualizing synaptic pruning in the mammalian brain - Science | AAAS
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Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner - Nature
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Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice - Nature
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Synaptic pruning through glial synapse engulfment upon motor learning - Nature
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Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration - Nature
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Schizophrenia's roots: Complement and synaptic pruning - Boston Children's Answers
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Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice - Nature
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UBE3A’s link to synaptic pruning bolstered by fly study - The Transmitter
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Dopamine D2 receptor regulates cortical synaptic pruning in rodents - Nature
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Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA - Nature
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Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning - Nature
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Disrupted Synaptic Pruning a Key Factor in Teen Mental Health at Risk - Neuroscience News
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S -ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning - Nature
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Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning - Nature
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Synaptic pruning deficits may cause tremor in essential tremor - MDEdge
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Concurrence of form and function in developing networks and its role in synaptic pruning - Nature
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Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior - Science | AAAS
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Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype - Nature
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New Insights Into Synaptic Pruning During Brain Development - Neuroscience News
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Problems with ‘pruning’ brain connections linked to adolescent mental health disorders - University of Cambridge
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Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects - Nature
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Synaptic Pruning Deficits in Autism Tied to Immune Cell Dysfunction - Technology Networks
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Schizophrenia: Ancient Scrolls, Genomic Sequencing and Synaptic Pruning - National Human Genome Research Institute (NHGRI) (.gov)
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Brain study finds evidence that autism involves too many synapses - Autism Speaks
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Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia - Nature
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Too Much Synaptic Pruning Can Lead to Neurodegeneration - Technology Networks
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Synaptic Pruning Discovery May Lead to New Therapies for Neuro Disorders - Genetic Engineering and Biotechnology News
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Synaptic Pruning Improves Autism in Mice - the-scientist.com
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Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain - Nature
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Discovery of an 'eat-me' signal involved in synaptic pruning and maturation of new neurons in the adult brain - Medical Xpress
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Phosphatidylserine is crucial for synaptic pruning in adult-born neurons - BioWorld News
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LTD-like molecular pathways in developmental synaptic pruning - Nature
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Hidden Hotspots: How New Synapse Clusters Shape the Teen Brain - OC Academy
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The Truth About The Way Kids' Brains Absorb New Languages - Forbes
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Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement - Frontiers
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The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking - Nature
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Loss of C9orf72 in Microglia Drives Neuronal Injury by Enhancing Synaptic Pruning in Aged and Alzheimer’s Disease Mice - Springer Nature Link
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Molecular signals in the developing brain | SYNSIGNAL Project | Results in Brief | FP7 - CORDIS
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Adolescent Brain Synapses: New Hotspots Challenge Schizophrenia Theory - OC Academy
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Microglia’s pruning function called into question - The Transmitter
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction - Nature
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Researchers Find the C4 Gene Is Involved with Synaptic Pruning and Associated with Schizophrenia - Neurology Today
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Sleep Shrinks the Brain--and That's a Good Thing - Scientific American
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Cannabis Worsens Brain Connectivity Deficits in Psychosis Risk - Neuroscience News
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Children with Autism Have Extra Synapses in Brain - Columbia University Irving Medical Center
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Here’s How Parenthood Changes Your Brain, Making You a Better Leader - inc.com
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Brains of children with autism teem with surplus synapses - The Transmitter
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GPR56 S4 variant is required for microglia‐mediated synaptic pruning - Wiley Online Library
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Complement-Mediated Synaptic Pruning During Development - Technology Networks
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Synapse Altering Drugs May Treat Schizophrenia, Autism - Pharmacy Times
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Scientists Capture Detailed Snapshots of Mouse Brain Cells Nibbling on Neurons - Neuroscience News
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This woman may know a secret to saving the brain's synapses - Science | AAAS
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Scientists Move Closer to Understanding Schizophrenia’s Cause (Published 2016) - The New York Times
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Problems with 'pruning' brain connections linked to adolescent mental health disorders - kcl.ac.uk
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Synaptic Loss Precedes Alzheimer’s Symptoms and Drives Disease, New Study Finds - Alzheimer's News Today
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Pruning hypothesis comes of age - Nature
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Microglia go pruning - Nature
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Immune system gene leads to schizophrenia clue - Science News
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Autism Linked to Excess Synapses in Adolescent Brains - Psychiatry Advisor
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Children with autism have extra synapses in brain - EurekAlert!
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Glial Cells Eating of Synapses May Enhance Learning and Memory - Neuroscience News
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Treatable mechanism identified in patients with schizophrenia - Karolinska Institutet
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Children with autism have extra brain synapses - ABC News & Headlines – Australian Broadcasting Corporation
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.