Why is "Splenomegaly" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-17 07:34:20
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Splenomegaly entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-17 and was most recently seen on 2026-04-17.
Wikipedia Overview
Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the potential for correction of these abnormalities by splenectomy. Splenomegaly is usually associated with increased workload, which suggests that it is a response to hyperfunction. It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of an enlarged spleen, along with caput medusae, is an important sign of portal hypertension.
Read more on Wikipedia →Related Topics
Trending Topic Today
Search Interest Perspective
-
Management of splenomegaly in patients with myelofibrosis in the era of JAK inhibitors: a comprehensive review - Frontiers
-
Hereditary Elliptocytosis Identified During the Evaluation of Splenomegaly: A Case Report - Cureus
-
Massive Splenomegaly as Initial Presentation of... : American Journal of Gastroenterology - Lippincott Home
-
Lactate-mediated macrophage polarization promotes splenomegaly in acute erythroleukemia - Nature
-
Incidental Splenomegaly: When to Look Further - NEJM Clinician
-
Incidentally detected splenomegaly may be risk factor for blood, liver cancers - Healio
-
Massive Splenomegaly: A Rare Cause of Partial... : American Journal of Gastroenterology - Lippincott Home
-
Massive Splenomegaly Secondary to Hematologic Dyscrasia - Cureus
-
A method for magnetic resonance splenomegaly image segmentation based on large-kernel multi-scale attention mechanism - Nature
-
Marked Haematologic Cancer Risk in Enlarged Spleens - EMJ
-
Chronic Myeloid Leukemia Masked by Massive Splenomegaly: Splenectomy as a Strategy in a Resource-Limited Setting - Cureus
-
Splenomegaly in Children and Adolescents - Frontiers
-
A European survey on allogeneic haematopoietic cell transplantation for myelofibrosis on behalf of the Chronic Malignancies Working Party of the EBMT: focus on ‘real world’ experience of JAK inhibitors, splenomegaly management and novel agents in the tra - Nature
-
Giant Hepatic Hemangioma With Secondary Portal... : American Journal of Gastroenterology - Lippincott Home
-
Diffuse Large B-Cell Lymphoma Presenting With Isolated Splenomegaly in a 42-Year-Old Female: A Rare Incidence of Primary Splenic Involvement - Cureus
-
Diagnostic Challenges in Seronegative Celiac Disease: A Case of Massive Splenomegaly and Persistent Metabolic Imbalance - Cureus
-
Aggressive B-cell Lymphoma Masquerading as Benign Epstein-Barr Virus (EBV)-Related Splenomegaly: An Analysis of Diagnostic Anchoring Bias - Cureus
-
A Study of the Clinico-Etiological Profile of Splenomegaly Among Children in a Tertiary Care Hospital - Cureus
-
Splenic Infarction as a Complication of Acute Epstein-Barr Virus Infection in an 18-Year-Old Woman - Cureus
-
Hepatic and Splenic Sarcoidosis Without Lymphadenopathy: An Atypical Multisystem Presentation - Cureus
-
A Recently Recognized and Underdiagnosed Entity of Splenic Diffuse Red Pulp Small B-Cell Lymphoma: A Report of Two Cases - Cureus
-
Isolated Splenic Infarcts as a Presentation of Diffuse Large B-Cell Lymphoma - Cureus
-
Splenomegaly in patients with primary or secondary myelofibrosis who are candidates for allogeneic hematopoietic cell transplantation: a Position Paper on behalf of the Chronic Malignancies Working Party of the EBMT - The Lancet
-
Unresolved Splenomegaly in Recently Resettled Congolese Refugees ― Multiple States, 2015–2018 - Centers for Disease Control and Prevention | CDC (.gov)
-
Pregnancy With Massive Splenomegaly and Pancytopenia: A Case Report - Cureus
-
Systemic Mastocytosis Presenting as Non-cirrhotic Portal Hypertension With Upper Gastrointestinal Bleeding in a Young Female Patient: A Case Report - Cureus
-
Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus - Frontiers
-
Exploring the Correlation Between Splenomegaly and Lung Involvement in COVID-19: A Retrospective Study - Cureus
-
Low-Dose Ruxolitinib Improves Splenomegaly and Symptoms in Myelofibrosis - Targeted Oncology
-
Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression - Nature
-
Predicting the probability of Gaucher disease in subjects with splenomegaly and thrombocytopenia - Nature
-
Cardiovascular Effects of Splenomegaly and Splenectomy in Beta-Thalassemia Major - Cureus
-
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model - Nature
-
Splenomegaly May Be a Negative Prognostic Factor in Essential Thrombocythemia and Polycythemia Vera - Oncology Nurse Advisor
-
Beyond splenomegaly: An image-based review of infectious and inflammatory diseases of the spleen - Applied Radiology
-
Massive Splenomegaly - NEJM
-
Adverse outcomes for chronic myeloid leukemia patients with splenomegaly and low in vivo kinase inhibition on imatinib - Nature
-
Sarcoidosis presenting as isolated massive splenomegaly: A case report - Wiley Online Library
-
Massive splenomegaly in a 6-year-old girl - Contemporary Pediatrics
-
Bacteremia, Fever, and Splenomegaly Caused by a Newly Recognized Bartonella Species - NEJM
-
Disseminated Mycobacterium avium-Intracellular Complex in an HIV Patient with HIV with Massive Splenomegaly - The American College of Surgeons
-
Splenomegaly Linked With Thrombosis, Cardiovascular Risk for Patients With ET and PV - ajmc.com
-
Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis - ASM Journals
-
Massive Splenomegaly in Hairy-Cell Leukemia - NEJM
-
Splenectomy for Primary Sjögren's Syndrome Associated with Massive Sp | IMCRJ - Dove Medical Press
-
Spleen volume in relation to ulcerative colitis and Crohn’s disease: a Mendelian randomization study - Nature
-
A Rare Presentation of Sarcoidosis in Which a Lady Presented With Massive Splenomegaly and Skin Manifestation Without Lung Involvement: A Case Report - Cureus
-
MOMENTUM Trial Outcomes: Guiding Therapy for Myelofibrosis With Anemia and Splenomegaly - Targeted Oncology
-
Splenunculus mimicking splenomegaly in a patient with synchronous herpes simplex 1 viremia and myelosuppression - Wiley Online Library
-
JAK Inhibitor Selection Strategy: Risk-Guided Approach and Treatment Goals for Splenomegaly and Anemia - Targeted Oncology
-
A wandering spleen, splenomegaly, hypersplenism, and iron deficiency anaemia - The Lancet
-
Massive Splenomegaly in Felty’s Syndrome: A Case Report - Cureus
-
Massive splenomegaly requiring differential diagnosis of hematologic malignancies - Wiley Online Library
-
[Figure, CT Splenomegaly Image courtesy O.Chaigasame] - StatPearls - National Institutes of Health (NIH) | (.gov)
-
A Case of Klippel-Trenaunay Syndrome With Gastrointestinal Hemorrhage and Splenomegaly - Cureus
-
Massive Splenomegaly from Disseminated Mycobacterium avium–intracellulare Infection - NEJM
-
Hemoglobin C Disease With Splenomegaly and With Factor II Mutation Gene Thrombophilia: A Case Report - Cureus
-
Case 6: 47-Year-Old Male With Leukocytosis, Anemia, and Splenomegaly - OncLive
-
Prognostic implications of splenomegaly in BCMA-directed CAR T-Cell therapy for relapsed myeloma - medrxiv.org
-
Anemia and splenomegaly in cGKI-deficient mice - PNAS
-
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes - Nature
-
AI with volumetric thresholds facilitate opportunistic screening for splenomegaly - Medical Xpress
-
Ruxolitinib versus best available therapy in inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): 5-year follow up of a randomised, phase 3b study - The Lancet
-
Massive splenomegaly due to splenic marginal zone B‐cell lymphoma - Wiley Online Library
-
The mechanisms behind thrombocytopenia in patients with portal hypertension and chronic liver disease - EurekAlert!
-
An Unusual Presentation of Vitamin B12 Deficiency Associated With Massive Splenomegaly, Hemolytic Anemia, and Pancytopenia: A Case Report - Cureus
-
AI With Volumetric Thresholds Facilitate Opportunistic Screening for Splenomegaly - Imaging Technology News
-
Splenomegaly Management in Myelofibrosis: Symptomatic and Asymptomatic Disease - Targeted Oncology
-
A laparoscopic approach to address massive splenomegaly, symptomatic cholelithiasis, and a planned postoperative pregnancy: A case report - Wiley Online Library
-
Applying enhanced recovery after surgery protocols in a patient with a giant spleen: a case report - Frontiers
-
Cirrhosis With Splenomegaly and Pancytopenia Complicating a Concurrent Diagnosis of Acute Lymphoblastic Leukemia - Cureus
-
Splenic irradiation for myelofibrosis prior to hematopoietic cell transplantation: A global collaborative analysis - Wiley Online Library
-
A Man With Fatigue, Leukocytosis, and Moderate Splenomegaly - Page 3 - Medscape Reference: Drugs, Diseases & Medical Procedures
-
Case 37-2016 | NEJM - NEJM
-
Recurrence of Stage IV Melanoma to the Spleen With Splenomegaly Treated With Laparoscopic Splenectomy - The American College of Surgeons
-
Splenomegaly ups thrombosis in essential thrombocythemia - Medical Xpress
-
When Systemic Lupus Erythematosus Meets Massive Splenomegaly: A Storage Disorder in Disguise - Springer Nature Link
-
Case 39-2008 | NEJM - NEJM
-
Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report - Frontiers
-
Persistent hypersplenism following successful hematopoietic stem cell transplantation: unraveling the cellular components of extramedullary residual disease and donor hematopoiesis—a case report - Frontiers
-
Fever, Lymphadenopathy, and Splenomegaly - Eleanor Gradidge, Aman Chauhan, Russel W. Steele, Raj Warrier, 2013 - Sage Journals
-
Bilateral Lymphadenopathy, Splenomegaly, and Hypercalcemia - Consultant360
-
Navigating Portal Hypertension and Splenomegaly: A Clinical Encounter With an Unusual Variant of Cruveilhier-Baumgarten Syndrome - Cureus
-
Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse - PLOS
-
Point Shear Wave Elastography for Splenic Assessment: A Comparative Study of Splenomegaly and Normal Spleens - Cureus
-
Clinical Decision-Making With PERSIST-2: Optimizing Therapy for Anemic Myelofibrosis Patients With Splenomegaly - Targeted Oncology
-
Retention of uninfected red blood cells causing congestive splenomegaly is the major mechanism of anemia in malaria - Wiley Online Library
-
Idiopathic Livedo Racemosa Presenting With Splenomegaly and Diffuse Lymphadenopathy - MDEdge
-
Ruxolitinib Demonstrates Clinical Activity in a Phase II Trial of Chronic Myelomonocytic Leukemia - The ASCO Post
-
IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice - Frontiers
-
Enlarged Spleen with a Heterogeneous Pattern - NEJM
-
Chronic Myelomonocytic Leukemia: Treatment and Prognosis, Part 2 - The ASCO Post
-
Spleen Stiffness Measurement Linked With Portal Hypertension in MPNs - ajmc.com
-
ROSAH syndrome: childhood-onset arthritis, hand deformities, uveitis, and splenomegaly - The Lancet
-
Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly - haematologica.org
-
Case #439 – March, 2017 - Centers for Disease Control and Prevention | CDC (.gov)
-
GSK’s Omjjara EU-cleared for splenomegaly in myelofibrosis - pharmaphorum
-
Oxaliplatin induces dose-dependent changes in haematological measures. - PLOS
-
AML1 deletion in adult mice causes splenomegaly and lymphomas - Nature
-
Splenic abscess secondary to brucellosis: a case report - SciELO México
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.