Why is "Rotenone" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-07-04 10:27:28
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Rotenone entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-07-04 and was most recently seen on 2026-07-04.
Wikipedia Overview
Rotenone is an organic compound that has been described as "by far the most important rotenoid." It is an odorless, colorless, crystalline isoflavone. It occurs naturally in the seeds and stems of several plants, such as the jicama vine, and in the roots of several other members of the Fabaceae. It was the first-described member of the family of chemical compounds known as rotenoids. Rotenone is approved for use as a piscicide to remove alien fish species, see Uses. It has also been used as a broad-spectrum insecticide, but its use as an insecticide has been banned in many countries.
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Trending Topic Today
Search Interest Perspective
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Nicotinamide counteracts Rotenone-induced mitochondrial and neuronal dysfunction in a translational early-life model - Nature
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Dopamine and Rotenone Modulate α-Synuclein Phase Separation and Liquid to Solid Transition - Wiley Online Library
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WDFW schedules public meeting on proposed rotenone treatment - The Miner Online
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Chasteberry extract alleviates rotenone-triggered testicular injury in rats by modulating oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction - Nature
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Rotenone is the "reset button" for fisheries, but what is it and how does F&G use it? - Idaho Fish and Game (.gov)
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Meeting scheduled on planned Westside Lake rotenone treatment to remove invasive northern pike - Washington Department of Fish and Wildlife (.gov)
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Reduced levels of nitrated α-synuclein in rotenone-induced cellular models of Parkinson's disease after harpagoside treatment - Frontiers
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Effects of Rotenone on Amphibians and Macroinvertebrates in Yellowstone - National Park Service (.gov)
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D-mannose alleviates rotenone-induced PD mouse model through microbiota-gut-brain axis - Nature
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Vitamin D3 Neuroprotection Against Rotenone and MPTP in SH‐SY5Y Cells - Wiley Online Library
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National Park Service Taking Action to Remove Invasive Predatory Fish from the Colorado River at Glen Canyon - National Park Service (.gov)
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MPTP and rotenone cause dopaminergic neuronal death by increasing DDIT4 promoter lactylation - Nature
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Therapeutic Effects of Cinnamaldehyde on Neuromuscular Function in Rat Parkinson's Model Induced by Rotenone - Wiley Online Library
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Neurotoxic effects of rotenone and deltamethrin prolonged exposure on adult zebrafish - Nature
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Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy | npj Parkinson's Disease - Nature
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Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model | npj Parkinson's Disease - Nature
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SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota - Nature
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Rotenone induced acute miRNA alterations in extracellular vesicles produce mitochondrial dysfunction and cell death - Nature
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Oleuropein confers neuroprotection against rotenone-induced model of Parkinson’s disease via BDNF/CREB/Akt pathway - Nature
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Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility - Nature
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Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster - Nature
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease - Frontiers
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The low-lethal concentrations of rotenone and pyrethrins suppress the population growth of Rhopalosiphum padi - Nature
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Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation | Scientific Reports - Nature
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Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease - Nature
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Exposure to the pesticide rotenone disrupts genes in Parkinson's-linked brain regions - Medical Xpress
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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration - Journal of Neuroscience
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Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease - Frontiers
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Vitamin K2 suppresses rotenone-induced microglial activation in vitro | Acta Pharmacologica Sinica - Nature
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Treatment of Baker Lake to Restore Bonneville Cutthroat Trout - National Park Service (.gov)
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Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels - Nature
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Sulforaphane protects against rotenone-induced neurotoxicity in vivo : Involvement of the mTOR, Nrf2 and autophagy pathways - Nature
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Rocky Mountain National Park to remove non-native fish from Kawuneeche Valley - SkyHiNews.com
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Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity - Nature
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Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson’s disease models - Nature
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Chemophobia in America: Part I — Rotenone - Hatch Magazine
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Rotenone: Starting Over - Bass Fishing Resource Guide
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Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease - Nature
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Lethal Rotenone Plan Aims to Trade Wilderness Rainbows for Cutthroat - Mountain Journal
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Mechanism of Toxicity in Rotenone Models of Parkinson's Disease - Journal of Neuroscience
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Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster - Journal of Neuroscience
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Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster - Journal of Neuroscience
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Chronic sleep restriction in the rotenone Parkinson’s disease model in rats reveals peripheral early-phase biomarkers - Nature
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Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility - Frontiers
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Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity - Nature
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Remove non-native fish without poisoning our streams - Daily Montanan
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to NIH/3T3 cells partially protects against rotenone induced cell death - Nature
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Rotenone fish removal projects are safe, effective and necessary - Daily Inter Lake
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DNR to use controversial pesticide to remove common carp, gizzard shad from Des Moines' Easter Lake - The Des Moines Register
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Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP - PNAS
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Oweep Basin Rotenone Treatment Starts This Month - Basin Now
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Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons - Journal of Neuroscience
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Does treatment with autophagy-enhancers and/or ROS-scavengers alleviate behavioral and neurochemical consequences of low-dose rotenone-induced mild mitochondrial dysfunction in mice? | Molecular Psychiatry - Nature
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Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's Disease - Journal of Neuroscience
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Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-XL/p53-mediated amplification mechanisms | Cell Death & Disease - Nature
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Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy - Nature
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Untargeted metabolomics reveal pathways associated with neuroprotective effect of oxyresveratrol in SH-SY5Y cells - Nature
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Stop use of rotenone in trout management, man urges Inslee - The Spokesman-Review
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What is Rotenone? | How Native Trout Waters Are Purged of Invasive Fish - Sports Illustrated
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease - Nature
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Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells - Wiley & Sons
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Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis - Frontiers
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Novel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson’s disease - Nature
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Rotenone Treatment And Closure Planned For South Fork Of Sheep Creek - Basin Now
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Navajo Lake to undergo rotenone treatment to kill chubs - St. George News
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Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells - Wiley Online Library
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DEC plans ‘reclamation’ of Echo Pond, killing fish so others may thrive - Adirondack Explorer
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Death tally after rotenone dose in Miramichi watershed: invasive fish 32, salmon 514 - CBC
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Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons - Journal of Neuroscience
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Ameliorative Effect of Quercetin on Neurochemical and Behavioral Deficits in Rotenone Rat Model of Parkinson's Disease: Modulating Autophagy (Quercetin on Experimental Parkinson's Disease) - Wiley Online Library
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Investigating the role of rotenone on human blood platelets: Molecular insights into abnormal platelet functions in Parkinson's disease - Wiley Online Library
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Iptakalim Alleviates Rotenone-Induced Degeneration of Dopaminergic Neurons through Inhibiting Microglia-Mediated Neuroinflammation - Nature
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Rotenone-induced nigrostriatal toxicity is reduced by methylene blue - Dove Medical Press
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Colorado wildlife managers plan to kill off existing fish, restock lake with native trout - CBS News
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Fish & Wildlife kill carp at ponds south of Pasco. Watch for eagles flocking in to feast - Tri-City Herald
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A toxic pesticide will be used to clean up Des Moines' choked Easter Lake. Residents fear it could give them Parkinson's - The Des Moines Register
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20141205_PN_Parkinsons - Pesticide Safety Education Program - Montana State University
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Neuroprotective actions of a fatty acid nitroalkene in Parkinson’s disease - Nature
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NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease - Nature
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The list of organic pesticides approved by the USDA - AGDAILY
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Two hydrologists blame toxin used to kill fish for Parkinson's diagnoses - Santa Fe New Mexican
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An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage - Journal of Neuroscience
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Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons - Journal of Neuroscience
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Plan to use fish killer rotenone in N.B. lake, river delayed by environmental assessment - CBC
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North Twin Lake may get rotenone treatment - bendbulletin.com
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Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons - Nature
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Pesticide use linked to Parkinson's disease - Nature
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Park will exterminate illegal goldfish in Kelly Warm Springs with rotenone - Buckrail
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Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone - Journal of Neuroscience
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Epcor pauses planned cull of invasive goldfish in west Edmonton stormwater pond - CBC
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Rotenone Usage To Target Nonnative Fish on Upper Gibbon River - Yellowstone Insider
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Exposure to pesticide disrupts genes in Parkinson’s-linked brain regions - Imperial College London
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Killing fish to save frogs - Sierra Nevada Ally
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Rotenone to Eradicate Gyrodactylus salaris in Norway - The Fish Site
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Plan calls for piscicide use to kill off invasive fish species in Colorado River - thespectrum.com
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Rotenone scrapped as weapon against invasive fish in Miramichi Lake - CBC
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Delayed in sensorimotor reflex ontogeny, slow physical growth, and impairments in behaviour as well as dopaminergic neuronal death in mice offspring following prenatally rotenone administration - Wiley Online Library
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Mann Lake gets a second round of rotenone for cutthroat restoration - OregonLive.com
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Modulation of astrocytic lactate metabolism by mitochondrial toxicants. - PLOS
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Salmon officials confirm first application of rotenone in Miramichi watershed - CBC
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.