Why is "Retinoic acid" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-14 17:59:35
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Retinoic_acid entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-14 and was most recently seen on 2026-04-14.
Wikipedia Overview
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. All-trans-retinoic acid is required for chordate animal development, which includes all higher animals from fish to humans. During early embryonic development, all-trans-retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages. In adult tissues, the activity of endogenous retinoic acid appears limited to immune function and male fertility.
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Trending Topic Today
Search Interest Perspective
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Retinoic acid drives cell fate specification, maturation and retinal regionality in human retinal organoids - Nature
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Human Organoids Reveal PTEN-Driven Mesendoderm Specification via Retinoic Acid Signaling Suppression - Science Partner Journals
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Retinoic Acid Informs the Positional Identity of Frontonasal Neural Crest Cells Through Alx Family of Transcription Factors - faseb.onlinelibrary.wiley.com
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Differential regulation of retinoic acid metabolism in Fanconi anemia - Nature
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Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer - ASM Journals
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Immune sabotage: How a Vitamin A byproduct compromises the body's normal anti-cancer response - Medical Xpress
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Treatment of spinal cord injury, by restoration of neuronal networks using a combination of surgery and KCL-286, an orally available retinoic acid receptor β drug - Frontiers
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Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid–regulated FGF1 - science.org
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Association of retinoids, retinoic acid receptors and epigenetics in breast cancer - Oncogene - Nature
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Retinoic acid deficiency alters second heart field formation - PNAS
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Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3 - PNAS
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All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer - Nature
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Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy - Nature
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Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate - Nature
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High-Risk neuroblastoma therapeutics Topotecan and 13-cis-Retinoic acid modulate autophagy and induce DNA damage response in hematopoietic stem cells and monocytes - Nature
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Retinoic acid in the development, regeneration and maintenance of the nervous system - Nature
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Impaired retinoic acid signaling in cerebral cavernous malformations - Nature
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Rapid retinoic acid-induced trophoblast cell model from human induced pluripotent stem cells | Scientific Reports - Nature
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Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2 - Nature
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Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration - Nature
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St. Jude scientists solve mystery of how the drug retinoic acid works to treat neuroblastoma - St. Jude Children's Research Hospital
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Retinoic acid induces human gastruloids with posterior embryo-like structures - Nature
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DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature
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Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations - Nature
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Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts - Nature
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All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis - Nature
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Mechanisms of retinoic acid signalling and its roles in organ and limb development - Nature
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Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools - Nature
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Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer - Nature
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Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma - science.org
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Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration - science.org
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Retinoic acid in development: towards an integrated view - Nature
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Dual effects of 9- cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues - Nature
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Uncovering how retinoic acid targets neuroblastoma - Nature
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Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia - NEJM
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Retinoic Acid-Dependent Loss of Synaptic Output from Bipolar Cells Impairs Visual Information Processing in Inherited Retinal Degeneration - Journal of Neuroscience
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Retinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma - Nature
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Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression - Nature
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Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases - Oliveira - 2018 - Mediators of Inflammation - Wiley Online Library
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Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter - Nature
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Retinoic acid suppresses colorectal cancer development - Stanford Medicine
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Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α - Nature
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Synergy of retinoic acid and BH3 mimetics in MYC(N) -driven embryonal nervous system tumours - Nature
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Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate - PNAS
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Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis - Nature
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Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5 - Nature
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A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein - Nature
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IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development - Nature
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EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma - Nature
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The role of retinoic acid in the production of immunoglobulin A - Nature
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Dynamic upregulation of retinoic acid signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation - Nature
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A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources - Nature
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A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment | Scientific Reports - Nature
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Unlocking the potential of retinoic acid in anticancer therapy - British Journal of Cancer - Nature
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Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers - Frontiers
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All-trans retinoic acid plus high-dose dexamethasone as first-line treatment for patients with newly diagnosed immune thrombocytopenia: a multicentre, open-label, randomised, controlled, phase 2 trial - The Lancet
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Axon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling - Nature
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Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR - PNAS
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Vitamin A and Retinoic Acid Act Synergistically to Increase Lung Retinyl Esters During Normoxia and Reduce Hyperoxic Lung Injury in Newborn Mice | Pediatric Research - Nature
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All-trans-retinoic acid ameliorates atherosclerosis, promotes perivascular adipose tissue browning, and increases adiponectin production in Apo-E mice - Nature
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Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation - Nature
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Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation - Nature
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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α (RARα) and oncogenic RARα fusion proteins - PNAS
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The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration - PNAS
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Structural insights into retinoic acid receptor activation and selective modulators - Wiley Online Library
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Prenatal retinoic acid exposure reveals candidate genes for craniofacial disorders - Nature
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An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial) - Nature
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Retinoic acid-mediated homeostatic plasticity drives cell type-specific CP-AMPAR accumulation in nucleus accumbens core and incubation of cocaine craving - Nature
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Regulation of prefrontal patterning and connectivity by retinoic acid - Nature
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Study Examines Availability of All-Trans Retinoic Acid in U.S. Hospitals - The ASCO Post
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Oral Arsenic and Retinoic Acid for Non–High-Risk Acute Promyelocytic Leukemia - NEJM
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Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha - PNAS
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Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity - Nature
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Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition - Nature
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Implication of retinoic acid receptor selective signaling in myogenic differentiation - Nature
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Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 - Nature
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Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning - PNAS
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Retinoic acid reduces the formation of, and acutely modulates, invertebrate electrical synapses - American Physiological Society Journal
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A paradoxical teratogenic mechanism for retinoic acid - PNAS
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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration - Nature
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Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome - Nature
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Retinoic acid signaling and metabolism in heart failure - American Physiological Society Journal
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Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies - Wiley Online Library
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Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway - Nature
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New Research Uncovers How Retinoic Acid Targets Metastatic Neuroblastoma Cells - Inside Precision Medicine
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Retinoic acid passes the morphogen test - Nature
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CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid—a promising combination strategy for therapeutic intervention - Nature
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Researchers Solve Mystery of Retinoic Acid’s Potency Against High-Risk Neuroblastoma - Dana-Farber Cancer Institute
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All-trans retinoic acid and dexamethasone regulate phagocytosis-related gene expression and enhance dead cell uptake in C2C12 myoblast cells - Nature
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Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 - Nature
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All-Trans Retinoic Acid and Arsenic Trioxide in High-Risk Acute Promyelocytic Leukemia - The ASCO Post
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Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing - Nature
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Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice - Rockefeller University Press
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Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis - PNAS
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Retinoic acid represses invasion and stem cell phenotype by induction of the metastasis suppressors RARRES1 and LXN - Nature
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A Darker Side to Retinoic Acid Revealed by Sarcomas - NEJM
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Role of PML in Cell Growth and the Retinoic Acid Pathway - science.org
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Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease - Frontiers
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Visualization of an endogenous retinoic acid gradient across embryonic development - Nature
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Restoring Retinoic Acid: Alleviating Autism-Like Behaviors in Sox5-Deficient Mice - Springer Nature Link
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.