Why is "RAGE (receptor)" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-26 23:37:05
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
RAGE_(receptor) entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-26 and was most recently seen on 2026-08-26.
Wikipedia Overview
RAGE, also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. Its name comes from its ability to bind advanced glycation end-products (AGEs), which include chiefly glycoproteins, the glycans of which have been modified non-enzymatically through the Maillard reaction. In view of its inflammatory function in innate immunity and its ability to detect a class of ligands through a common structural motif, RAGE is often referred to as a pattern recognition receptor. RAGE also has at least one other agonistic ligand: high mobility group protein B1 (HMGB1). HMGB1 is an intracellular DNA-binding protein important in chromatin remodeling which can be released by necrotic cells passively, and by active secretion from macrophages, natural killer cells, and dendritic cells.
Read more on Wikipedia →Related Topics
Trending Topic Today
Search Interest Perspective
-
Deconstructing the RAGE signaling maze: the molecular key to opening a new dimension of ovarian anti-aging - Nature
-
Russia Develops ‘Anti-Aging Vaccine’ Targeting Cellular Aging - The Moscow Times
-
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease - Wiley Online Library
-
Using Artificial Intelligence to Learn More about RAGE Receptors - UC San Diego Today
-
Receptor for AGE (RAGE) Mediates Neointimal Formation in Response to Arterial Injury - American Heart Association Journals
-
RAGE signaling regulates the progression of diabetic complications - Frontiers
-
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane - Nature
-
Advanced glycation end products regulate the receptor of AGEs epigenetically - Frontiers
-
Soluble Forms of the Receptor for Advanced Glycation Endproducts (RAGE) in Periodontitis - Nature
-
HMGB1/RAGE axis in tumor development: unraveling its significance - Frontiers
-
Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems - Nature
-
Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes - Nature
-
Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains - Nature
-
RAGE signaling inhibition prevents the malignant phenotypes of pancreatic ductal adenocarcinoma cells - Nature
-
The Gly82Ser polymorphism in the receptor for advanced glycation endproducts increases the risk for coronary events in the general population - Nature
-
Aging promotes a RAGE-dependent increase in breast cancer metastasis | Communications Biology - Nature
-
Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches - Nature
-
RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke - Nature
-
Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes - Nature
-
New route for COVID-19 into human cells found by scientists - Nature
-
The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer - Nature
-
Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis - Nature
-
The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases - Frontiers
-
RAGE regulates oxytocin transport into the brain - Nature
-
The Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes - Nature
-
Phosphatidylserine receptors: what is the new RAGE? - Springer Nature Link
-
The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival - Nature
-
Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer’s disease - Nature
-
Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets | Scientific Reports - Nature
-
Mouse Specific Cleavage-Resistant RAGE Splice Variant - PLOS
-
Interaction of the Receptor for Advanced Glycation End Products (RAGE) with Transthyretin Triggers Nuclear Transcription Factor kB (NF-kB) Activation - Nature
-
Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p -AKT/Bcl-2 pathways - Nature
-
RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice - Nature
-
Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways - Nature
-
The RAGE Pathway May Play Roles in Both Obesity & COVID-19 - NYU Langone Health
-
AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression - Nature
-
RAGE Implicated in Worsening Breast Cancer Mortality with Age - Genetic Engineering and Biotechnology News
-
Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury - Nature
-
The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice - Nature
-
Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs - Nature
-
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE - Nature
-
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex - ERS - European Respiratory Society
-
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE: - American Heart Association Journals
-
The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions - Springer Nature Link
-
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes - Nature
-
The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease? - Nature
-
Why breast cancer becomes more deadly with age - Medical Xpress
-
A Novel Therapeutic Approach to Obesity & Diabetes - NYU Langone Health
-
Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex - Journal of Neuroscience
-
Shaminem(@Shaminem-Creator)'s insights - Binance
-
Russian scientists developing 'RAGE' gene therapy to extend life expectancy | Russian President Putin is 73 years old | Inshorts - Inshorts
-
Russia unveils ‘Anti-aging Vaccine’: A gene therapy targeting cellular decay - The News International
-
Putin's quest for immortality: Russian scientists develop 'RAGE' gene therapy to extend life to 150 years - Zee News
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.