Why is "Protease" trending?

Search Interest Perspective

• Is protease really good for you? Here’s what the science says - health.com
• Alkaline Serine Protease Market Outlook to 2035 - IndexBox
• Deep learning guided design of protease substrates - Nature
• A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen - PNAS
• Recurrent acquisition of nuclease-protease pairs in antiviral immunity - Science | AAAS
• Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients - Journal of Neuroscience
• Protease Market Size, Analysis, Share, Growth, 2026-2034 - Fortune Business Insights
• An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models - Nature
• Pathogen-inspired engineering of plant protease enhances late blight resistance - PNAS
• Structural basis for prohibitin-mediated regulation of mitochondrial m -AAA protease - Nature
• Clade C MERS-CoV camel strains vary in protease utilization during viral entry - PNAS
• Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - Nature
• Identification and engineering of highly functional potyviral proteases in cells using co-evolutionary models - Nature
• catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis - Nature
• Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders - Nature
• YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice - Nature
• Effect of sonication and protease inhibitors on Elisa quantification of selected proteins in bovine udder tissue homogenates - Nature
• Kazal-type serine protease inhibitors from Arabidopsis thaliana and Toxoplasma gondii exhibit antimicrobial activity against plant pathogens - Nature
• The apoplastic protein OsCPIP8 confers dual protection by inhibiting pathogenic protease and activating rice immunity - Nature
• Structures of Helicobacter pylori C-terminal protease CtpA reveal a new mode of self-contained proteolytic processing - Nature
• Genome sequence of protease-free Bacillus subtilis KO7-S strain created for protein production - ASM Journals
• Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial - The Lancet
• Functional identification of a feather-degrading thermitase-like S8 serine protease from Fervidobacterium islandicum AW-1 - Frontiers
• Genome sequence of protease-free Bacillus anthracis BH500 strain created for protein production - ASM Journals
• Protease-activated receptor 1 as an endogenous model of peptidergic Gαq-Gα12-biased G protein signaling - Frontiers
• Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology - PNAS
• A gasdermin-based life–death evolution system for reprogramming protease specificity - Nature
• Mitochondrial AAA+ protease activity uncovers differential sensitivity of Drosophila blood cell lineages to systemic cues - Frontiers
• Therapeutic potential of tubular serine protease inhibitors in proteinuria - American Physiological Society Journal
• The roles of serine protease inhibitors in dermatoses - Frontiers
• Integrated Forward and Reverse Degradomics of Aortic Aneurysms Uncovers Their Proteolytic Landscapes and the Roles of MMP9 and Mast Cell Chymase - American Heart Association Journals
• Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease - Wiley Online Library
• Data-driven protease engineering by DNA-recording and epistasis-aware machine learning - Nature
• Multiscale profiling of protease activity in cancer - Nature
• Profiling protease cleavage patterns in plasma for pancreatic cancer detection - Nature
• Identifying and controlling inactive and active conformations of a serine protease - Science | AAAS
• Orthogonalized human protease control of secreted signals - Nature
• Conformational ensembles reveal the origins of serine protease catalysis - Science | AAAS
• Mechanism-based traps enable protease and hydrolase substrate discovery - Nature
• A generalizable approach for programming protease-responsive conformationally inhibited artificial transcriptional factors - Nature
• Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease - Frontiers
• Enzymatic combinatorial synthesis of E-64 and related cysteine protease inhibitors - Nature
• Protease-controlled secretion and display of intercellular signals - Nature
• Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening - Nature
• Targeted degradation of α-Synuclein using an evolved botulinum toxin protease - PNAS
• In-brain synthesis of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry - Nature
• Profiling plasma protease activity with charge-changing peptides enables detection and classification of gastrointestinal cancers - Nature
• Protease-based synthetic sensing and signal amplification - PNAS
• Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis - Nature
• Targeted approach to determine the impact of cancer-associated protease variants - Science | AAAS
• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors - Science | AAAS
• Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors - Science | AAAS
• Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries - PNAS
• Ultralarge Virtual Screening Identifies SARS-CoV‑2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses - ACS Publications
• Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation - Nature
• Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries - PNAS
• The heat shock protein LarA activates the Lon protease in response to proteotoxic stress - Nature
• HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations - PNAS
• Substrate profiling of marine-derived thermotolerant cysteine protease reveals unique cleavage preferences for industrial applications - Nature
• An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila - Science | AAAS
• Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex - Science | AAAS
• Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes - Nature
• Chemical tools to define and manipulate interferon-inducible Ubl protease USP18 - Nature
• Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability - Nature
• Craspase is a CRISPR RNA-guided, RNA-activated protease - Science | AAAS
• Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M - Science | AAAS
• HIV protease: late action to prevent immune detection | Signal Transduction and Targeted Therapy - Nature
• A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation - Nature
• Altered host protease determinants for SARS-CoV-2 Omicron - Science | AAAS
• Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition - Nature
• Purification and characterization of cysteine protease of Sarcocystis fusiformis from infected Egyptian water buffaloes - Nature
• Directed evolution improves the catalytic efficiency of TEV protease - Nature
• Effects of exogenous protease addition on fermentation and nutritive value of rehydrated corn and sorghum grains silages - Nature
• The roles of plant proteases and protease inhibitors in drought response: a review - Frontiers
• Optimization of protease production by newly isolated Bacillus sp. from the Red Sea using defatted soybean cake - Nature
• The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor - PNAS
• Nucleophilic proteases: Structure, function, regulation and disease - American Society for Biochemistry and Molecular Biology
• Structures of the human LONP1 protease reveal regulatory steps involved in protease activation - Nature
• A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment - Nature
• Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity - Nature
• An improved variant of tobacco etch virus (TEV) protease that does not need reducing agents - Wiley Online Library
• Distinct quaternary structures of the AAA+ Lon protease control substrate degradation - PNAS
• A novel alkali and thermotolerant protease from Aeromonas spp. retrieved from wastewater - Nature
• E40, a novel microbial protease efficiently detoxifying gluten proteins, for the dietary management of gluten intolerance - Nature
• A programmable protease-based protein secretion platform for therapeutic applications - Nature
• Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP - Science | AAAS
• Evolution of cyclic peptide protease inhibitors - PNAS
• Complete three-dimensional structures of the Lon protease translocating a protein substrate - Science | AAAS
• A clogged gutter mechanism for protease inhibitors - PNAS
• The expanded immunoregulatory protease network in mosquitoes is governed by gene coexpression - PNAS
• Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease - Science | AAAS
• A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis - Nature
• Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins - PNAS
• Ddi1 is a ubiquitin-dependent protease - PNAS
• Plant Products as Inhibitors of Coronavirus 3CL Protease - Frontiers
• Amplified fluorescence sensing of protease activity with conjugated polyelectrolytes - PNAS
• Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity - Nature
• Protease Activity in Vascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors - PNAS
• Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate - PNAS