Why is "Phosphatidylinositol 4,5-bisphosphate" trending?

Search Interest Perspective

• Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling - PNAS
• synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis - Nature
• Definition of phosphatidylinositol 4,5-bisphosphate distribution by freeze-fracture replica labeling - Rockefeller University Press
• Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics - Nature
• Effect of hormone-induced plasma membrane phosphatidylinositol 4,5-bisphosphate depletion on receptor endocytosis suggests the importance of local regulation in phosphoinositide signaling - Nature
• Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin - PNAS
• Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains - Nature
• Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K - Nature
• A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing - Nature
• The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation - Nature
• Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate - Nature
• ) roles for synaptic plasticity using chemically induced dimerization - Nature
• Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells - Nature
• ) facilitates norepinephrine transporter dimerization and modulates substrate efflux - Nature
• Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate - Nature
• Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment - Nature
• Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow - Nature
• Structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes | Communications Chemistry - Nature
• Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation - Nature
• The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P - Nature
• A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique - PNAS
• Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling - PNAS
• Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium - Journal of Neuroscience
• A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate - Nature
• ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5) P - Nature
• Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity | Scientific Reports - Nature
• Plasmalemmal Phosphatidylinositol-4,5-Bisphosphate Level Regulates the Releasable Vesicle Pool Size in Chromaffin Cells - Journal of Neuroscience
• Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation - Science | AAAS
• Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli - PNAS
• Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane - PNAS
• Relationship between Membrane Phosphatidylinositol-4,5-Bisphosphate and Receptor-Mediated Inhibition of Native Neuronal M Channels - Journal of Neuroscience
• Phosphatidylinositol-4,5-bisphosphate 3-kinase PI3K) inhibitors reduce vascular inflammation in vitro and in vivo - British Pharmacological Society | Journals
• Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation - Frontiers
• Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries - Nature
• Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism - Nature
• Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P - Nature
• A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate - PNAS
• cotransporter NBCe1-A expressed in Xenopus oocytes - PNAS
• Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate - PNAS
• Tools to Tamper with Phosphoinositides - Science | AAAS
• Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate - Rockefeller University Press
• Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC - Nature
• Regulation of Kv7 (KCNQ) K+ Channel Open Probability by Phosphatidylinositol 4,5-Bisphosphate - Journal of Neuroscience
• Functional Recovery from Desensitization of Vanilloid Receptor TRPV1 Requires Resynthesis of Phosphatidylinositol 4,5-Bisphosphate - Journal of Neuroscience
• Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production - Science | AAAS
• PIP2: A critical regulator of vascular ion channels hiding in plain sight - PNAS
• Functional Control of Cold- and Menthol-Sensitive TRPM8 Ion Channels by Phosphatidylinositol 4,5-Bisphosphate - Journal of Neuroscience
• An Arabidopsis mutant deficient in phosphatidylinositol-4-phosphate kinases ß1 and ß2 displays altered auxin-related responses in roots - Nature
• The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters - Science | AAAS
• Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate - PNAS
• Lipid give and take - Nature
• Phosphotidylinositol 4,5-Bisphosphate Signals Underlie Receptor-Specific G - Journal of Neuroscience
• Allosteric modulation of alternatively spliced Ca2+-activated Cl− channels TMEM16A by PI(4,5)P2 and CaMKII - PNAS
• A molecular determinant of phosphoinositide affinity in mammalian TRPV channels - Nature
• Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating - PNAS
• PI(3,4,5)P3 and PI(4,5)P2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane - Science | AAAS
• Unconventional phosphoinositide synthesis - American Society for Biochemistry and Molecular Biology
• signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis - ASM Journals
• Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair - Rockefeller University Press
• Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation - Nature
• Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily - Rockefeller University Press
• Dual Regulation of Voltage-Sensitive Ion Channels by PIP2 - Frontiers
• Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome - PNAS
• The phosphoinositide regulatory network in Trypanosoma brucei: Implications for cell-wide regulation in eukaryotes - PLOS
• Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation - PNAS
• PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes - Rockefeller University Press
• ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D - PNAS
• Dual Regulation of TRPV1 by Phosphoinositides - Journal of Neuroscience
• PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma - Nature
• Phosphatidylinositol‐3,5‐Bisphosphate: No Longer the Poor PIP2 - Wiley Online Library
• A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin - Science | AAAS
• The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel - Wiley & Sons
• When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response - Frontiers
• Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled - Nature
• Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins - Nature
• Large Membrane Domains in Hair Bundles Specify Spatially Constricted Radixin Activation - Journal of Neuroscience
• Structural and mechanistic insights into the association of PKCα-C2 domain to PtdIns(4,5)P2 - PNAS
• PIP2 signaling in lipid domains: a critical re‐evaluation - The EMBO Journal - Springer Nature Link
• Self assembly of HIV-1 Gag protein on lipid membranes generates PI(4,5)P - Nature
• DNA damage causes rapid accumulation of phosphoinositides for ATR signaling - Nature
• Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating - PNAS