Why is "Phenytoin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-22 03:30:35
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Phenytoin entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-22 and was most recently seen on 2026-08-22.
Wikipedia Overview
Phenytoin, sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic–clonic seizures and focal seizures, but not absence seizures. The intravenous form, fosphenytoin, is used for status epilepticus that does not improve with benzodiazepines. It may also be used for certain heart arrhythmias or neuropathic pain. It can be taken intravenously or by mouth. The intravenous form generally begins working within 30 minutes and is effective for roughly 24 hours. Blood levels can be measured to determine the proper dose.
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Trending Topic Today
Search Interest Perspective
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Unexplained encephalopathy with phenytoin... : Neurology India - Ovid
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Esophagitis and Esophageal Ulceration... : American Journal of Gastroenterology - Lippincott Home
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Multidisciplinary Management of Phenytoin-Induced Gingival Enlargement: A Case Report - Cureus
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Electrospun bi-layer carboxymethyl cellulose/polyvinyl alcohol/polycaprolactone nanofibers: fabrication, degradation, and phenytoin release kinetics - Nature
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Intensive adverse drug reaction monitoring program improves detection | PPA - Dove Medical Press
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‘Phenytoin : Neurology India - Ovid
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Phenytoin Associated with Greater Bone Loss in Young Women with Epilepsy - Neurology Today
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Parnell Launches Pentobarbital Sodium and Phenytoin Sodium Euthanasia Solution for Dogs - Business Wire
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A bitter pill: Court of Appeal restores CMA’s Phenytoin excessive pricing decision (via Passle) - Bristows
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Tribunal was “wrong” to reject CMA phenytoin decision, says Court - GOV.UK
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11 Phenytoin Interactions to Know Before Taking - GoodRx
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Lupin receives U.S. FDA approval for Extended Phenytoin Sodium Capsules USP - Lupin | Press Release - lupin.com
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Pharmacokinetic profile of phenytoin in dried blood spot with high-performance liquid chromatography—photodiode array - Frontiers
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Court of Appeal to reconsider £69m fines over ‘excessive’ pricing of epilepsy drug - The Pharmaceutical Journal
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DRESS syndrome and flare-up due to antiepileptics: how to solve the problem - www.elsevier.com
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Managing Epilepsy in Pregnancy: ASM Safety and Neurodevelopmental Risks - Endocrinology Advisor
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Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial - The Lancet
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Folic Acid Supplements in Children with Epilepsy Found to Reduce Gingival Overgrowth - Neurology Today
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Phenytoin induced pellagrous dermatitis and its... : Indian Journal of Paediatric Dermatology - Ovid
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Plasmapheresis as an Adjunctive Therapy in... : Global Journal of Transfusion Medicine - Ovid
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Investigation on the phenytoin sodium channel-blocker effect in PDT of MDA MB 231 breast cancer using a positively charged PS - Nature
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Treating Status Epilepticus: Phenytoin Versus Levetiracetam - Cureus
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Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model - Nature
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Print Article - CMAJ | Journal
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Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial - The Lancet
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Orolingual Dyskinesia and Involuntary Neck Movements Caused by Phenytoin Intoxication - Psychiatry Online
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Antiepileptic Drug-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Case Series - Cureus
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A Rare Case of Hemodialysis as an Extracorporeal Treatment for Severe Phenytoin Overdose - Cureus
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Deep eutectic solvents for antiepileptic drug phenytoin solubilization: thermodynamic study - Nature
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Phenytoin-Induced Severe Thrombocytopenia: A Case Report - Cureus
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Purple Glove Syndrome: Recognizing a Rare Complication of Intravenous Phenytoin - Cureus
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Phenytoin- Medication That Warrants Deviation From Standard Approach for Thyroid Lab Interpretation - Cureus
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Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus - The New England Journal of Medicine
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The Six Antiepileptic Drugs with the Highest Risk for Adverse Skin Reactions - Neurology Today
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Effects of Antiepileptic Drugs, Carbamazepine and Phenytoin, on Plasma Concentrations of Clozapine and Its N‐Desmethyl and N‐Oxide Metabolites in Japanese Patients With Schizophrenia - Wiley Online Library
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A Comparison of Seizure Prophylaxis: Phenytoin Versus Levetiracetam - Cureus
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Longstanding Phenytoin Use as a Cause of Progressive Dyspnea - ScienceDirect.com
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Efficacy of Topical Phenytoin in the Management of Diabetic Foot Ulcers: A Systematic Review - Cureus
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A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis - Nature
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A Comparison of Magnesium Sulfate with Phenytoin for the Prevention of Eclampsia - The New England Journal of Medicine
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Phenytoin‐induced dysglycemia in a child : Pediatrics International - Ovid
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Efficacy of Switching to Levetiracetam After S-1-Induced Phenytoin Concentration Increase: A Case Report - Cureus
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A decision re-made: the CAT's decision on phenytoin sodium - ashurstperkinscoie.com
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A Randomized, Double-Blind Study of Phenytoin for the Prevention of Post-Traumatic Seizures - The New England Journal of Medicine
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CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy - Nature
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How do patients’ genes affect their medication choice? - Kaiser Permanente Division of Research
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Phenobarbital Compared with Phenytoin for the Treatment of Neonatal Seizures - The New England Journal of Medicine
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Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165 - Frontiers
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Significance of Oral Manifestations in the Diagnosis of Severe Phenytoin-Induced Thrombocytopenia: A Rare Case - Cureus
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Pfizer fined record £84.2m for overcharging NHS - BBC
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Topical Phenytoin Improves Wound Healing With Analgesic and Antibacterial Properties and Minimal Side Effects: A Systematic Review - HMP Global Learning Network
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Phenytoin-Induced Toxic Epidermal Necrolysis - Cureus
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Levetiracetam no better than phenytoin in children with convulsive status epilepticus - The Lancet
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No anti-seizure drug given in Zara’s initial treatment, court told - Free Malaysia Today
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Current Scenarios and Future Perspectives of Therapeutic Drug Monitoring in India: A Narrative Review - Cureus
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Phenytoin - Springer Nature Link
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Phenytoin-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap in Focus: A Case Report - Cureus
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Levofloxacin/phenytoin interactions - Springer Nature Link
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Phenytoin: neuroprotection or neurotoxicity? - Springer Nature Link
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Association analysis of CYP2C9*3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children - Nature
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Levetiracetam is a useful alternative to phenytoin in stopping prolonged epileptic seizures in children - NIHR
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Early-Onset Epileptic Encephalopathy Responsive to Phenytoin: A Diagnostic Clue for Fibroblast Growth Factor 12 Mutation - Cureus
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Gingival Hyperplasia Induced by Phenytoin - The New England Journal of Medicine
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Phenytoin: an old but effective antiarrhythmic agent for the suppression of ventricular tachycardia - Medical Journal of Australia (MJA)
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Topical Phenytoin Demonstrates Improved Wound Healing - HMP Global Learning Network
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Topiramate/phenytoin/phenobarbital/sultiame - Springer Nature Link
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Excessive Pricing: Impact of the Le Patourel and Phenytoin rulings - ashurstperkinscoie.com
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Drug-Drug Interactions Leading to Tacrolimus Toxicity in a Renal Transplant Patient With COVID-19: The Role of Paxlovid and the Mitigating Use of Phenytoin - Cureus
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Fetal hypoxia and hyperglycemia in the formation of phenytoin-induced cleft lip and maxillary hypoplasia - Wiley Online Library
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Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system - Nature
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Epilepsy control with phenobarbital or phenytoin in rural south India: the Yelandur study - The Lancet
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Albendazole/levetiracetam/phenytoin - Reactions Weekly - Springer Nature Link
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The perils of antiepileptic toxicity - Australian Prescriber
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Reversible lesion involving the splenium of the corpus callosum caused by phenytoin sodium withdrawal - Springer Nature Link
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Sodium Channel Blocker Phenytoin Eases Seizures in 4 Dravet Patients - Dravet Syndrome News
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Levetiracetam versus Phenytoin in Status Epilepticus (ConSEPT and EcLiPSE) - First10EM
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GENE MUTATIONS LINKED TO SEVERE PHENYTOIN-RELATED SKIN REACTIONS IN EPILEPSY - Neurology Today
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Calcium Phosphate-Based Nanoformulation Selectively Abolishes Phenytoin Resistance in Epileptic Neurons for Ceasing Seizures - Wiley Online Library
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11 Common Antiepileptic Seizure Medications to Know - GoodRx
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Phenytoin Oral Suspension Recalled Due to Potential for Inaccurate Dosing - Medical Professionals Reference
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Epilepsy Drug May Be Neuroprotective in Optic Neuritis - Neurology Advisor
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Role of Intravenous Levetiracetam in Seizure Prophylaxis of Severe Traumatic Brain Injury Patients - Frontiers
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Lack of Efficacy of Phenytoin in Recessive Dystrophic Epidermolysis Bullosa - The New England Journal of Medicine
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Phenytoin Toxicity May Lead to Cerebellar Atrophy - Top Class Actions
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Angioedema Risk Evaluated for Levetiracetam Versus Phenytoin - Medical Professionals Reference
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Antiepileptic drugs and apoptotic neurodegeneration in the developing brain - PNAS
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Phenytoin protects against optical damage in multiple sclerosis - The Pharmaceutical Journal
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A randomized phase II study of SM‐88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond - Wiley Online Library
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P2-081: CHARACTERIZATION OF COGNITIVE DISRUPTING PROPERTIES OF PHENYTOIN IN ADULT AND AGED RATS - Wiley & Sons
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Anticonvulsant Use and Outcomes After Intracerebral Hemorrhage | Stroke - American Heart Association Journals
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Abdominal Epilepsy and Phenytoin Induced Pure Red Cell Aplasia-Unusual Presentation With Review of Literature - Wiley Online Library
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Topical phenytoin solution for treating pressure ulcers: a prospective, randomized, double-blind clinical trial - Nature
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No medications were administered to Zara on the way to hospital - NST Online
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Epilepsy and the Elderly - HMP Global Learning Network
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Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin - Springer Nature Link
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Steady-state Pharmacokinetics of Phenytoin from Routinely Collected Patient Data - Springer Nature Link
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Drug Interaction Leads to Undetectable Levels of Oral Anticoagulant in Patient - Medical Professionals Reference
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Persistent Bradycardia with the Long-term Use of Phenytoin and Oxycodone: First Case Report - Cureus
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Intravenous push administration of anti-seizure medications - Frontiers
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The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.