Why is "P-glycoprotein" trending?

Search Interest Perspective

• P-glycoprotein inhibitory activity of angiotensin II receptor blockers and DOAC-related bleeding risk: Clinical implications and future directions - Nature
• Induction of cytochrome P450 2C9 and P-glycoprotein activity by antiseizure medications: A systematic review and network meta-analysis - Wiley Online Library
• Atorvastatin Interactions: Risks, Effects, & Recommendations - The Cardiology Advisor
• Mapping the inhibition landscape of P-glycoprotein via conformational ensemble docking - Nature
• In Vitro characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status - Frontiers
• Ilunocitinib-induced pancytopenia in an Australian Shepherd dog with the MDR1 mutation - American Animal Hospital Association - AAHA
• Experimental Copper-Based Drug Clears Alzheimer’s Plaques and Boosts Memory in Mice - Sci.News
• Copper drug clears toxic Alzheimer’s proteins and restores memory - ScienceDaily
• Lab trials prove copper therapy enhances cognitive function and spatial learning - News-Medical
• This Copper Drug Clears Alzheimer’s Brain Toxins and Boosts Memory - SciTechDaily
• Alzheimer’s Research Takes Unexpected Turn Toward Copper - StudyFinds
• Comparative bleeding risk between angiotensin II receptor blockers with high versus low P-glycoprotein inhibitory activity in patients with atrial fibrillation receiving direct oral anticoagulants - Nature
• Multi-transporter models for blood-brain barrier studies - News-Medical
• P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers - Frontiers
• Targeted proteomics for accurate P-glycoprotein quantification - News-Medical
• Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion - Nature
• Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption - Nature
• Cryo-EM of human P-glycoprotein reveals an intermediate occluded conformation during active drug transport - Nature
• Structure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains - Nature
• Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1) - Nature
• Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells - PNAS
• Localized Down-regulation of P-glycoprotein by Focused Ultrasound and Microbubbles induced Blood-Brain Barrier Disruption in Rat Brain - Nature
• Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation - Science | AAAS
• Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein - Nature
• Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells - Nature
• Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity - Nature
• Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding - Science | AAAS
• BPS Publications - British Pharmacological Society | Journals
• Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1 - Nature
• Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells - Nature
• RSK1 protects P-glycoprotein/ABCB1 against ubiquitin–proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1 - Nature
• Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells - Nature
• Repertoire of P-glycoprotein drug transporters in the zoonotic nematode Toxocara canis - Nature
• Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations - Nature
• Aβ1–42 reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling | Cell Death & Disease - Nature
• Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein - PNAS
• Dynamics of ABC Transporter P-glycoprotein in Three Conformational States - Nature
• RETRACTED ARTICLE: Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance - Nature
• Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans - Nature
• P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate | Scientific Reports - Nature
• A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation - Nature
• Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane - Nature
• Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer - Nature
• Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions - Nature
• Essential role of P-glycoprotein in the mechanism of action of oliceridine - Nature
• Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein - Nature
• Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics - Nature
• A single active catalytic site is sufficient to promote transport in P-glycoprotein | Scientific Reports - Nature
• Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain - PNAS
• Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules - Nature
• The P-glycoprotein repertoire of the equine parasitic nematode Parascaris univalens - Nature
• P-Glycoprotein Drives Glioblastoma Survival and Chemotherapy Resistance: Potential as a Promising Liquid Biopsy Biomarker - ScienceDirect.com
• Utilizing surface plasmon resonance as a novel method for monitoring in-vitro P-glycoprotein efflux - Frontiers
• The ontogeny of P-glycoprotein in the developing human blood–brain barrier: implication for opioid toxicity in neonates - Nature
• Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin - Nature
• Editorial: FDA-Approved Drug Repositioning for P-Glycoprotein Overexpressing Resistant Cancer - Frontiers
• The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane - PNAS
• Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice - Nature
• Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation - ScienceDirect.com
• Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells - PNAS
• P-Glycoprotein Function at the Blood–Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys - Journal of Nuclear Medicine
• Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy - Nature
• Aβ40 Reduces P-Glycoprotein at the Blood–Brain Barrier through the Ubiquitin–Proteasome Pathway - Journal of Neuroscience
• Structural modification of P-glycoprotein induced by OH radicals: Insights from atomistic simulations - Nature
• PSMA-Targeted Nanoparticles with PI3K/mTOR Dual Inhibitor Downregulate P-Glycoprotein and Inactivate Myeloid-Derived Suppressor Cells for Enhanced Chemotherapy and Immunotherapy in Prostate Cancer - Wiley & Sons
• Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models - Nature
• Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity - Nature
• Deciphering the Relative Contribution of CYP3A4 Versus P-Glycoprotein for the Shared Substrate Cyclosporine—Commentary on Lown et al - Wiley & Sons
• Increasing BMI is associated with reduced expression of P-glycoprotein ( ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians - Nature
• Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein - Nature
• PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors - ScienceDirect.com
• Nanoparticle that Mimics Salmonella Counteracts Chemotherapy Resistance - National Cancer Institute (.gov)
• New test can flag drugs that could be harmful to cats - WSU Insider
• MDR1-P-glycoprotein behaves as an oncofetal protein that promotes cell survival in gastric cancer cells - Nature
• Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression - Nature
• P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses - Frontiers
• Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P -glycoprotein-mediated multidrug resistance in MCF-7/ADR cell - Nature
• Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function - Frontiers
• Cyclosporine-A-mediated inhibition of p-glycoprotein increases methylprednisolone entry into the central nervous system - Nature
• Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats - Nature
• REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer - Nature
• C-Verapamil Transfer at the Human Blood–Brain Barrier for Evaluation of P-glycoprotein Function - Journal of Nuclear Medicine
• Imaging the Activity of Efflux Transporters at the Blood–Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria - Journal of Nuclear Medicine
• A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC | Cell Death & Disease - Nature
• Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol - Wiley Online Library
• P-gp expression in brown trout erythrocytes: evidence of a detoxification mechanism in fish erythrocytes - Nature
• Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells - Nature
• The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions | Neuropsychopharmacology - Nature
• The influence of a caveolin-1 mutant on the function of P-glycoprotein - Nature
• Interactions of retinoids with the ABC transporters P-glycoprotein and Breast Cancer Resistance Protein - Nature
• Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using - Journal of Nuclear Medicine
• Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken - Nature
• Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET - PNAS
• Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects - Nature
• P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation - Nature
• Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier - PNAS
• Olanzapine Penetration into Brain is Greater in Transgenic Abcb1a P-glycoprotein-Deficient Mice than FVB1 (Wild-Type) Animals - Nature
• Study of Allosteric Transitions of Human P-Glycoprotein by Using the Two-State Anisotropic Network Model - Frontiers
• Serum p-glycoprotein and monomeric C-reactive protein are novel biomar | JIR - Dove Medical Press
• P-glycoprotein: from genomics to mechanism - Nature