Why is "Osteocyte" trending?

Search Interest Perspective

• Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling - Nature
• Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis - Wiley & Sons
• CFTR mediates Cl- transport in osteocytes to sustain cell viability and skeletal homeostasis - Nature
• Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis - Frontiers
• Cholinergic regulation of osteocyte mechanobiology: A paradigm for bone adaptation - Science | AAAS
• The role of ferroptosis in osteoporosis: a cellular perspective on osteoblast, osteoclast and osteocyte dysfunction - Frontiers
• Piezo1-mediated mechanotransduction controls osteocyte maturation and dendrite development via a YAP-CCN-Src signaling axis - Nature
• Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression - Nature
• Editorial: Molecular and cellular mechanisms of bone remodeling - Frontiers
• Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis - Nature
• Repositioning osteocytes as integrative regulators of breast cancer bone metastasis - Nature
• Real-time visualization and modulation of endocytic dynamics in osteocytes in vivo - Nature
• Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease - Nature
• Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice - Nature
• Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression - Nature
• Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation - Nature
• Osteocyte mitochondria regulate angiogenesis of transcortical vessels - Nature
• Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin - Nature
• Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement - Nature
• CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors - Nature
• The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States - Frontiers
• Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis | Bone Research - Nature
• Osteocyte CIITA aggravates osteolytic bone lesions in myeloma - Nature
• Bundling of collagen fibrils influences osteocyte network formation during bone modeling - Nature
• Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging | Bone Research - Nature
• Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity - Science | AAAS
• Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis - Nature
• Osteocyte calcium signals encode strain magnitude and loading frequency in vivo - PNAS
• Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression - Nature
• Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression - Nature
• Osteocyte-mediated mechanical response controls osteoblast differentiation and function - Frontiers
• Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis - Nature
• Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture - Nature
• Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection - Nature
• Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process - PNAS
• Control of Bone Matrix Properties by Osteocytes - Frontiers
• Cell Condensation Triggers the Differentiation of Osteoblast Precursor Cells to Osteocyte-Like Cells - Frontiers
• PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid-Induced Osteoporosis by Suppressing Osteocyte Ferroptosis - Wiley & Sons
• A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction - Nature
• Vinculin Force Sensor Detects Tumor-Osteocyte Interactions - Scientific Reports - Nature
• Identification of an intronic enhancer regulating RANKL expression in osteocytic cells | Bone Research - Nature
• Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23 - Nature
• Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone? - Guerra - 2025 - Cytoskeleton - Wiley Online Library
• Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics - Nature
• Osteocyte death promotes bone loss - Nature
• Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y - Wiley & Sons
• Novel insights into osteocyte and inter-organ/tissue crosstalk - Frontiers
• The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases - Frontiers
• Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes - Nature
• SIKs control osteocyte responses to parathyroid hormone - Nature
• WISH-BONE: Whole-mount in situ histology, to label osteocyte mRNA and protein in 3D adult mouse bones - Wiley & Sons
• Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network - Science | AAAS
• A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency - Frontiers
• Multiomic analysis of stretched osteocytes reveals processes and signalling linked to bone regeneration and cancer - Nature
• Osteocyte morphology and orientation in relation to strain in the jaw bone - Nature
• One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons - Nature
• Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5 - Nature
• Evidence for osteocyte regulation of bone homeostasis through RANKL expression - Nature
• Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer - Nature
• Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes - Nature
• Differential gene expression in trabecular bone osteocytes is related to the local strain and strain gradient - Nature
• Bone metabolism and evolutionary origin of osteocytes: Novel application of FIB-SEM tomography - Science | AAAS
• Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions - Nature
• Spatial control of perilacunar canalicular remodeling during lactation - Nature
• Spheroid co-culture of BMSCs with osteocytes yields ring-shaped bone-like tissue that enhances alveolar bone regeneration - Nature
• Lewis Lab investigates intriguing role of osteocytes in bone health - Cornell Chronicle
• Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis - Nature
• P62 acts as an intermediator in cadmium-induced osteocyte apoptosis and osteoporosis in mice - ScienceDirect.com
• Aging disrupts osteocyte networks and bone structure, with greater impact in males - EurekAlert!
• Mechanical properties of trabeculae and osteocyte morphology change significantly in different areas of the necrotic femoral head - Frontiers
• Saos‐2 cells cultured under hypoxia rapidly differentiate to an osteocyte‐like stage and support intracellular infection by Staphylococcus aureus - Wiley & Sons
• Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin - Nature
• oscillations in osteocytes release extracellular vesicles and enhance bone formation - Nature
• Ex vivo 3D osteocyte network construction with primary murine bone cells - Nature
• 3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes - Nature
• Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis - Nature
• Genetically engineered mouse model provides insights on genetic bone disorders - EurekAlert!
• Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis | Scientific Reports - Nature
• MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts - Nature
• Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes - Nature
• Uniaxially fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis - Nature
• Osteocyte-derived exosomes confer multiple myeloma resistance to chemotherapy through acquisition of cancer stem cell-like features - Nature
• Vertebral bone microarchitecture and osteocyte characteristics of three toothed whale species with varying diving behaviour - Nature
• Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line - Nature
• Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes - Nature
• Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage - Nature
• Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats - Nature
• Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes - Nature
• Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts - Nature
• Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes | Bone Research - Nature
• Osteocyte specific responses to soluble and mechanical stimuli in a stem cell derived culture model - Nature
• Roles of osteocytes in phosphate metabolism - Frontiers
• Immune mechanism found in osteocyte cells could lead to drug target to prevent spread of cancer to bones - Medical Xpress
• Remodeling in bone without osteocytes: Billfish challenge bone structure–function paradigms - PNAS
• Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation - Nature
• Forceful mastication activates osteocytes and builds a stout jawbone - Nature
• Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model - Wiley Online Library
• Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation | Scientific Reports - Nature
• Study to explore nerve-like behavior of bone cells with NSF grant - Cornell Chronicle
• Architecture of the osteocyte network correlates with bone material quality - Wiley Online Library