Why is "Osteoclast" trending?

Search Interest Perspective

• Targeting the Ip6k2–Runx2 axis disrupts osteoblast–osteoclast coupling to treat osteoporosis - Nature
• Beyond resorption: targeting osteoclast fusion and polarization to restore balanced bone remodeling - Frontiers
• Moesin strikes an “Actin”g balance to regulate osteoclast fusion and activity - Rockefeller University Press
• M-CSF priming enhances the efficiency and reproducibility of hiPSC-derived osteoclast differentiation and pharmacological responsiveness to anti-resorptive agents - Nature
• Keeping inflammasomes in check during bone resorption - Science | AAAS
• Beyond resorption-driven coupling: a multi-layered framework for osteoclast–osteoblast communication and its therapeutic consequences - Frontiers
• Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion - Rockefeller University Press
• Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases - Nature
• Osteoclast Heterogeneity in Aging: New Tools to Decode Bone Resorption and Remodeling - Frontiers
• Moesin controls cell–cell fusion and osteoclast function - Rockefeller University Press
• Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis - Nature
• Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis - Nature
• The role of ferroptosis in osteoporosis: a cellular perspective on osteoblast, osteoclast and osteocyte dysfunction - Frontiers
• PIDDosome deficiency impairs bone remodeling by increasing osteoclast ploidy and function - Nature
• Human peripheral osteoclast-precursor-development patterns reveal the significance of RPS17-dependent ribosome synthesis to Ankylosing Spondylitis lesions - Nature
• Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly - Nature
• In silico exploration of osteoclast precursor inhibition for preventing rapid bone loss after denosumab discontinuation - Nature
• The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis | Scientific Reports - Nature
• Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis - Nature
• Kaempferol inhibits osteoclast differentiation and bone resorption by targeting the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways - Nature
• Scientists discover how vitamin K pathway regulates bone remodeling - News-Medical
• Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes - Wiley & Sons
• Osteoclast-rich undifferentiated carcinoma of the bladder and the diagnostic usefulness of immunohistochemistry. A case report - www.elsevier.com
• Bone Cells Use Vitamin K Signals to Regulate Osteoclast Fusion - The National Law Review
• Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases | Experimental & Molecular Medicine - Nature
• Scaffold-Mediated Microenvironmental Modulation Targeting Osteoclasts for ONFH Niche Reprogramming - Science Partner Journals
• Functional and analytical recapitulation of osteoclast biology on demineralized bone paper - Nature
• Macrophages and osteoclasts: similarity and divergence between bone phagocytes - Frontiers
• Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity - Nature
• Osteoclastic variant of anaplastic thyroid... : Journal of Cancer Research and Therapeutics - Ovid
• The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression - Nature
• Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk - Nature
• Oxypaeoniflorin Prevents Titanium Particle-Induced Bone Loss by Reprogramming Osteoclast Mitochondria via Nrf2 - Bioengineer.org
• Glycobiology in osteoclast differentiation and function - Nature
• Recent Advances in Osteoclast Biological Behavior - Frontiers
• Sialylation of TLR2 initiates osteoclast fusion - Nature
• Rac1-dependent regulation of osteoclast and osteoblast differentiation by developmentally regulated GTP-binding 2 - Nature
• Real-time analysis of osteoclast resorption and fusion dynamics in response to bone resorption inhibitors - Nature
• Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis - Nature
• Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors - Nature
• Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis - Science | AAAS
• Undifferentiated pancreatic carcinoma with osteoclast-like cells: case report - SciELO México
• Cell cycle checkpoint factor p15Ink4b is a novel regulator of osteoclast differentiation | Scientific Reports - Nature
• The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis - Frontiers
• A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver - Nature
• IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism - Nature
• Mechanical stimulation controls osteoclast function through the regulation of Ca - Nature
• Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors - Nature
• Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups - Frontiers
• Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs - Nature
• Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation - Frontiers
• Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins - Nature
• Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation - Nature
• Metallothionein 3 promotes osteoclast differentiation and survival by regulating the intracellular Zn - Nature
• Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153 - Nature
• Bone, dentin and cementum differentially influence the differentiation of osteoclast-like cells - Nature
• CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors - Nature
• Centrosome clustering control in osteoclasts through CCR5-mediated signaling - Nature
• CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex - Nature
• Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases - Science | AAAS
• Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1 - Nature
• Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds - Science | AAAS
• DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation - Nature
• IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95 - Nature
• p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner - Nature
• Evidence for excessive osteoclast activation in SIRT6 null mice - Nature
• The Roles of Acidosis in Osteoclast Biology - Frontiers
• VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice - pnas.org
• 1: Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1 - keio.ac.jp
• Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis - Nature
• TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment - Nature
• Visual Osteoclast Fusion via A Fluorescence Method - Nature
• Spi-C positively regulates RANKL-mediated osteoclast differentiation and function - Nature
• Suppression of osteoclast multinucleation via a posttranscriptional regulation–based spatiotemporally selective delivery system - Science | AAAS
• Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development - Nature
• Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation - Nature
• TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation - Nature
• Role of RANKL Signaling in Bone Homeostasis - American Physiological Society Journal
• Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade - pnas.org
• Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression - pnas.org
• RACK1 interaction with c-Src is essential for osteoclast function - Nature
• P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis | Scientific Reports - Nature
• The RANK/RANKL axis controls vascular dynamics in the bone marrow - pnas.org
• Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis - Science | AAAS
• IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1 - pnas.org
• Stimulation of osteoclast migration and bone resorption by C–C chemokine ligands 19 and 21 - Nature
• Osteoclasts and giant cells:... : International Journal of Experimental Pathology - Ovid
• The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings - Frontiers
• Removal of Osteoclast Bone Resorption Products by Transcytosis - Science | AAAS
• Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis - Bioengineer.org
• CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity - Nature
• Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway - Nature
• Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway - Nature
• Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation - Nature
• Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass - Nature
• Mitochondrial fatty acid β-oxidation is important for normal osteoclast formation in growing female mice - Frontiers
• Inhibition of Osteoclast Differentiation and Bone Resorption by Bisphosphonate-conjugated Gold Nanoparticles - Nature
• Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis - Nature
• Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate - Nature
• Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass - Nature