Why is "Notch signaling pathway" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-02 07:12:29
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Notch_signaling_pathway entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-02 and was most recently seen on 2026-06-02.
Wikipedia Overview
The Notch signaling pathway is a highly conserved cell signaling system present in most animals. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region.
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Trending Topic Today
Search Interest Perspective
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Targeting the Notch signaling pathway: molecular mechanisms and therapeutic strategies for cardiac repair after myocardial infarction - Frontiers
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Activated notch signaling pathway protects the intestinal barrier in DSS-induced colitis by regulating tight junctions - Springer Nature Link
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Notch signaling pathway: architecture, disease, and therapeutics - Nature
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AI-designed protein activates Notch signaling pathway to boost T-cell production - News-Medical
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Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer - Frontiers
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WSGC@FA@PEG/PEI-SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy - Wiley & Sons
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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos - PNAS
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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies - Nature
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ALDH1A1 promotes colorectal cancer metastasis through activating the notch signaling pathway - Springer Nature Link
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Notch Signaling Pathway - News-Medical
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Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia - Nature
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Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases - Frontiers
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Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells - Nature
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The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease - Frontiers
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The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma - Nature
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ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway - Nature
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Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway | Scientific Reports - Nature
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NELL2 suppresses epithelial-mesenchymal transition and induces ferroptosis via notch signaling pathway in HCC - Nature
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Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations - Nature
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Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway - Nature
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A crucial mechanism in immune response: NOTCH signaling pathway plays essential role in CD8⁺ T cell differentiation - Medical Xpress
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Effect of Sortilin1 on promoting angiogenesis and systemic metastasis in hepatocellular carcinoma via the Notch signaling pathway and CD133 | Cell Death & Disease - Nature
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The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation - Rockefeller University Press
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Non-coding RNAs affect breast cancer development through the notch signaling pathway - Medical Xpress
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Association between novel genetic variants of Notch signaling pathway genes and survival of hepatitis B virus-related hepatocellular carcinoma - Wiley Online Library
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CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway - Frontiers
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An enhanced triple fluorescence flow-cytometry-based assay shows differential activation of the Notch signaling pathway by human papillomavirus E6 proteins - Nature
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Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia-reperfusion injury - Wiley Online Library
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Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway - Nature
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The Notch signaling pathway in hematopoiesis and hematologic malignancies - Haematologica
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Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes - Nature
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Notch Signaling Pathway and Endocrine Resistance in Breast Cancer - Frontiers
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3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway - Nature
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Notch Signaling Pathway Expression in the Skin of Leprosy Patients: Association With Skin and Neural Damage - Frontiers
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MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development - Wiley Online Library
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miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway | Scientific Reports - Nature
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RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway - Nature
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Exploring the Protective Effect of Total Flavonoids from Semen Cuscutae on Ovarian Germline Stem Cells Based on Notch Signaling Pathway - Springer Nature Link
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Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway - Nature
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Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective - Frontiers
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NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway - Frontiers
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KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties - Nature
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Notch Signaling, Brain Development, and Human Disease - Pediatric Research - Nature
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Activation of Notch signaling pathway precedes heart regeneration in zebrafish - PNAS
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Attenuated Notch signaling in schizophrenia and bipolar disorder - Nature
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HIF- 1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway - Nature
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Cell signaling pathway linked to obesity, Type 2 diabetes - Purdue University
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Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia - Nature
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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway - Nature
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Circulation Research: CNIC Researchers identify a new signaling mechanism implicated in congenital aortic valve disease - cnic.es
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.