Why is "NADPH" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-01 00:37:51
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
NADPH entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-01 and was most recently seen on 2026-08-01.
Wikipedia Overview
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require it as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP+ is the oxidized form. The reduced form, NADPH is used by all forms of cellular life as an electron donor as part of many biosynthetic reactions.
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Trending Topic Today
Search Interest Perspective
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NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions - Nature
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Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi - ASM Journals
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NADPH Oxidase/Antioxidant Dual-Target Intervention Reduces Radiation-Induced Embryo Defects in Mice - spj.science.org
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Pancreatic Cancer Development Driven by NADPH Disruption - Inside Precision Medicine
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NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys - American Heart Association Journals
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NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine | Molecular Psychiatry - Nature
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BPS Publications - British Pharmacological Society | Journals
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Spinach and Light Power a Dry Eye Relief Solution - the-scientist.com
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Eyes that photosynthesise: NUS scientists plant a cure for dry eye disease - EurekAlert!
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Renox Reloaded: How Metabolic Reprogramming by the NADPH Oxidase Nox4 Promotes Salt-Sensitive Hypertension - American Heart Association Journals
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Spinach-Based Eye Drops Could Help Treat a Common Eye Condition - ScienceAlert
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NADPH alleviates LPS-induced neuropathology and depression-like behaviors by suppressing microglial inflammatory response - Nature
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NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease - Wiley & Sons
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Identification of a novel NADPH generation reaction in the pentose phosphate pathway in Escherichia coli using mBFP - ASM Journals
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NADPH acts as an endogenous P2X7 receptor modulator to gate neuroinflammatory responses of microglia - Nature
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Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism - Nature
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A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature
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Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase - Nature
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The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled) - Nature
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Chanoclavine synthase operates by an NADPH-independent superoxide mechanism - Nature
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In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD+ fluorescent protein sensors - Nature
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NADPH oxidase family proteins: signaling dynamics to disease management - Nature
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NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism - Nature
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Copper oxide-based cathode for direct NADPH regeneration - Scientific Reports - Nature
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Cytosolic and mitochondrial NADPH fluxes are independently regulated - Nature
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Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death - Nature
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Electrical stimulation facilitates NADPH production in pentose phosphate pathway and exerts an anti-inflammatory effect in macrophages - Nature
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Targeting ROS production through inhibition of NADPH oxidases - Nature
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Structure of dimerized assimilatory NADPH-dependent sulfite reductase reveals the minimal interface for diflavin reductase binding - Nature
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Structure of the core human NADPH oxidase NOX2 - Nature
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NADPH oxidases: an overview from structure to innate immunity-associated pathologies - Nature
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Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise - Nature
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Separating NADH and NADPH fluorescence in live cells and tissues using FLIM - Nature
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SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila - Nature
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MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma | Cell Death & Disease - Nature
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Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae - Nature
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Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome - PNAS
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The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis - Nature
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Structure of human phagocyte NADPH oxidase in the activated state - Nature
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A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells - Nature
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A genetically encoded tool for manipulation of NADP - Nature
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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress - Nature
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Orchestrating ROS regulation: coordinated post-translational modification switches in NADPH oxidases - Wiley & Sons
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Aging-related NADPH diaphorase positive neurodegenerations in the sacral spinal cord of aged non-human primates - Nature
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NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment - Nature
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Reporting NADPH fluxes - Nature
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The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves - Nature
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Serine catabolism generates liver NADPH and supports hepatic lipogenesis - Nature
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N-glycosylation of SnRK2s affects NADPH maintenance in peroxisomes during prolonged ABA signalling - Nature
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Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance - Frontiers
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NUS scientists plant a cure for dry eye disease using photosynthesis - Vietnam Investment Review - VIR
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Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction - Nature
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FSP1 oxidizes NADPH to suppress ferroptosis - Nature
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NADPH oxidase mediated oxidative stress signaling in FLT3-ITD acute myeloid leukemia | Cell Death Discovery - Nature
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Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism - Nature
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Beyond the Extra Respiration of Phagocytosis: NADPH Oxidase 2 in Adaptive Immunity and Inflammation - Frontiers
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NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex - Nature
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Synthetic Nicotinamide Cofactors as Alternatives to NADPH in Imine Reductase-Catalyzed Reactions - ACS Publications
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MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis - Nature
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NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods - Nature
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NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy - Nature
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The phagocytosis oxidase/Bem1p domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity - Wiley & Sons
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Regulatory role of NADPH oxidases in symbiosis and dysbiosis in the sea anemone Aiptasia - Frontiers
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Navigating ferroptosis via an NADPH sensor - Nature
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NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius - Nature
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Quantitative flux analysis reveals folate-dependent NADPH production - Nature
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NADH and NADPH peroxidases as antioxidant defense mechanisms in intestinal sulfate-reducing bacteria - Nature
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NADPH diaphorase detects S-nitrosylated proteins in aldehyde-treated biological tissues - Nature
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Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst - PNAS
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NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D - Journal of Neuroscience
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ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation - Nature
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Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
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Plant parasitic cyst nematodes redirect host indole metabolism via NADPH oxidase-mediated ROS to promote infection - Wiley & Sons
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NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1α axis in thyroid carcinomas - Nature
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The NADPH oxidase NOX2 mediates loss of parvalbumin interneurons in traumatic brain injury: human autoptic immunohistochemical evidence - Nature
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A novel monoclonal antibody reveals the enrichment of NADPH oxidase 5 in human splenic endothelial cells - Nature
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sensitivity of Bifidobacterium longum subsp. infantis - Nature
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The multi-faceted role of NADPH in regulating inflammation in activated myeloid cells - Frontiers
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The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts - Frontiers
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-lactate dehydrogenase that can super-efficiently utilize NADPH and NADH as cofactors - Nature
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Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons - Nature
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Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells | Scientific Reports - Nature
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NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease - Nature
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Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage - Nature
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Illuminating redox biology using NADH- and NADPH-specific sensors - Nature
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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment - PNAS
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Overcoming NADPH product inhibition improves D-sorbitol conversion to L-sorbose - Nature
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Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase - American Heart Association Journals
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Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells - PNAS
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Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis - Nature
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Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells - Nature
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Tomato SlRbohB, a member of the NADPH oxidase family, is required for disease resistance against Botrytis cinerea and tolerance to drought stress - Frontiers
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contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1 - Nature
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Is Photosynthesis‐Derived NADPH Really a Source of 2H‐Depleted Hydrogen in Plant Compounds? - onlinelibrary.wiley.com
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Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease - The New England Journal of Medicine
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NADPH Oxidase Gene, FgNoxD, Plays a Critical Role in Development and Virulence in Fusarium graminearum - Frontiers
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NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets - Nature
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Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA - PNAS
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Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation - PNAS
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Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity - American Heart Association Journals
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.