Why is "Mevalonate pathway" trending?

Search Interest Perspective

• Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway–dependent Rho/ROCK signaling - PNAS
• Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway - Nature
• Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response - Nature
• Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate - PNAS
• USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer - Nature
• Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro - PNAS
• Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization - Nature
• Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy - Nature
• p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells | Cell Death & Disease - Nature
• The mevalonate pathway regulates primitive streak formation via protein farnesylation - Nature
• The mevalonate pathway is an actionable vulnerability of t (4;14)-positive multiple myeloma - Nature
• TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia - Nature
• MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer - Nature
• An Adaptation To Life In Acid Through A Novel Mevalonate Pathway - Nature
• Activation of the plant mevalonate pathway by extracellular ATP - Nature
• MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway - Nature
• Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin - Nature
• Control of the innate immune response by the mevalonate pathway - Nature
• Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus - Nature
• p53 regulates the mevalonate pathway in human glioblastoma multiforme - Nature
• Targeting mutant p53 through the mevalonate pathway - Nature
• Consequences of blunting the mevalonate pathway in cancer identified by a pluri-omics approach - Nature
• Metabolic control of YAP and TAZ by the mevalonate pathway - Nature
• Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions - Frontiers
• In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells - Nature
• DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway - Nature
• Combined targeting of mevalonate pathway/PRC2 shows anticancer effect in BAP1-mutated mesothelioma - BioWorld News
• Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion | Scientific Reports - Nature
• The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans - PNAS
• Zoledronic acid targets the mevalonate pathway causing reduced cell recruitment and attenuation of pulmonary fibrosis | Newswise - Newswise
• The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway - PNAS
• Effect of farnesol on mevalonate pathway of Staphylococcus aureus - Nature
• Mevalonate pathway and male reproductive aging - Wiley Online Library
• Engineering a mevalonate pathway in Escherichia coli for production of terpenoids - Nature
• GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway - Nature
• Correction to: TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia - Nature
• The Farnesyltransferase Inhibitors Tipifarnib and Lonafarnib Inhibit Cytokines Secretion in a Cellular Model of Mevalonate Kinase Deficiency - Nature
• Synthesis of Mevalonate Pathway Lipids in Fibroblasts from Zellweger and X-linked ALD Patients - Nature
• HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway - Nature
• Cholesterol-Lowering Drugs Inhibit Brown Fat Activity - Genetic Engineering and Biotechnology News
• Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy - Frontiers
• A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus - Nature
• Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor - Nature
• Biosynthetic studies on terpenoids produced by Streptomyces - Nature
• Mevalonate Metabolism in Immuno-Oncology - Frontiers
• Classification of Terpenoids according to the Methylerythritolphosphate or the Mevalonate Pathway with Natural - Wiley Online Library