Why is "Mef2" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-08-24 00:49:24
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Mef2 entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-08-24 and was most recently seen on 2026-08-24.
Wikipedia Overview
In the field of molecular biology, myocyte enhancer factor-2 (Mef2) proteins are a family of transcription factors which through control of gene expression are important regulators of cellular differentiation and consequently play a critical role in embryonic development. In adult organisms, Mef2 proteins mediate the stress response in some tissues. Mef2 proteins contain both MADS-box and Mef2 DNA-binding domains.
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Trending Topic Today
Search Interest Perspective
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Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease - Nature
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A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy - American Heart Association Journals
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An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133 - PNAS
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Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number - Science | AAAS
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Study links gene to cognitive resilience in the elderly - MIT News
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Conserved NPPB+ Border Zone Switches From MEF2- to AP-1–Driven Gene Program | Circulation - American Heart Association Journals
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The MEF2A transcription factor interactome in cardiomyocytes - Nature
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mef2 activity levels differentially affect gene expression during Drosophila muscle development - PNAS
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Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number - Science | AAAS
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MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program - American Heart Association Journals
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CABIN1 peptide effectively targets MEF2D-fusion protein in B-cell precursor acute lymphoblastic leukemia - Nature
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Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo - PNAS
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Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers - Nature
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Requirement of MEF2A, C, and D for skeletal muscle regeneration - PNAS
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MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity - Nature
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A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy - American Heart Association Journals
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Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion - Nature
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Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers | Cell Death Discovery - Nature
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Heart disease: recruitment of MEF2 activity by β −blockers wards off cardiomyocyte death - Nature
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ImmunoCheckDB: A Comprehensive Platform for Evaluating Cancer Immunotherapy Biomarkers Through Meta‐Analyses and Multiomic Profiling - Lu - 2025 - MedComm – Future Medicine - Wiley Online Library
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Deep learning methods for protein structure prediction - Qin - 2024 - MedComm – Future Medicine - Wiley Online Library
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Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral Effects of Oxytocin - Frontiers
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Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4 - Rockefeller University Press
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TGF‐β‐activated Smad3 represses MEF2‐dependent transcription in myogenic differentiation - Springer Nature Link
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Conserved NPPB+ Border Zone Switches From MEF2- to AP-1–Driven Gene Program | Circulation - American Heart Association Journals
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Suppression of a MEF2-KLF6 Survival Pathway by PKA Signaling Promotes Apoptosis in Embryonic Hippocampal Neurons - Journal of Neuroscience
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Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2A - PNAS
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MALT1: The Dual Domains Drive Resistance to Immune Checkpoint Inhibitors - Wiley Online Library
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Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5 - PNAS
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Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis - Nature
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MEF2 negatively regulates learning-induced structural plasticity and memory formation - Nature
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Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium - Nature
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A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells - Nature
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G9a inhibits MEF2C activity to control sarcomere assembly - Nature
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Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation - Journal of Neuroscience
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Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster - Nature
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Coronary Artery Disease and the MEF2A Transcription Factor - Science | AAAS
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Antitumor effects of TIM‐1 blockade in B cells - Liu - 2024 - MedComm – Future Medicine - Wiley Online Library
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MEF2C shapes the microtranscriptome during differentiation of skeletal muscles - Nature
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Advancing Surgical Practice With Mixed Reality: Current Innovations and Future Prospects - Wiley Online Library
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Members of the Myocyte Enhancer Factor 2 Transcription Factor Family Differentially Regulate Bdnf Transcription in Response to Neuronal Depolarization - Journal of Neuroscience
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Dysbiosis of gut microbiome contributes to glaucoma pathogenesis - Chen - 2022 - MedComm – Future Medicine - Wiley Online Library
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The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis - PNAS
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Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches - Wiley Online Library
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E2F function in muscle growth is necessary and sufficient for viability in Drosophila - Nature
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The Mef2c Gene Dose-Dependently Controls Hippocampal Neurogenesis and the Expression of Autism-Like Behaviors - Journal of Neuroscience
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Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow - PNAS
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Exercise increases MEF2A abundance in rat cardiac muscle by downregulating microRNA-223-5p - Nature
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Breakthrough in bidirectional skin-organ crosstalk unveils novel therapeutic avenues for systemic diseases — international team identifies skin as a central hub for systemic inflammation regulation - EurekAlert!
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Lithocholic Acid Activates TULP3‐Sirtuin‐v‐ATPase‐AMPK Axis to Enhance Longevity - Wiley Online Library
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Myotonic dystrophy disrupts normal control of gene expression in the heart - Baylor College of Medicine Blog Network -
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MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation - Nature
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Small‐molecule drugs as RNA‐targeted degraders - Huang - 2023 - MedComm – Future Medicine - Wiley Online Library
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Deep-learning-based diagnosis of myopia in children using optical coherence tomography angiography - Wiley Online Library
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Artificial Intelligence in Medical Education: A Practical Guide for Educators - Patil - 2025 - MedComm – Future Medicine - Wiley Online Library
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Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila - PNAS
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Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina - American Heart Association Journals
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HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements - Frontiers
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Beta-blockers promote heart muscle cell survival following a heart attack - Medical Xpress
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Base Editing Corrects Autism Variant in Mouse Brain - Genetic Engineering and Biotechnology News
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Chemical switch found in Alzheimer’s and stroke victims’ brains kills neurons - ZME Science
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Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D - Nature
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MEF2C mediates the activation induced cell death (AICD) of macrophages - Nature
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Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration - Nature
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Differential Contributions of Caenorhabditis elegans Histone Deacetylases to Huntingtin Polyglutamine Toxicity - Journal of Neuroscience
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Mitochondrial Complex I activity signals antioxidant response through ERK5 - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.