Why is "Lipoic acid" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-23 14:09:27
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Lipoic_acid entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-23 and was most recently seen on 2026-06-23.
Wikipedia Overview
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA, which is made in animals normally, is essential for aerobic metabolism. It is also available as a dietary supplement or pharmaceutical drug in some countries. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA under physiological conditions. Only the (R)-(+)-enantiomer (RLA) exists in nature. RLA is an essential cofactor of many processes.
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Trending Topic Today
Search Interest Perspective
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Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide | Scientific Reports - Nature
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Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy - American Academy Of Family Physicians | AAFP
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Lipoic acid for multiple sclerosis - Multiple Sclerosis News Today
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A Randomised Open Label Clinical Trial With Oral... : American Journal of Gastroenterology - Lippincott Home
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Mixed results in using lipoic acid to treat progressive multiple sclerosis - OHSU News
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Alpha-Lipoic Acid and Leucine as Adjunct Therapy for Persistent First-Trimester Subchorionic Hematomas in Assisted Reproductive Technology Pregnancies - Cureus
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Efficacy of Alpha-Lipoic Acid in Patients With Ischemic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Study - JACC Journals
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Country Life Coenzyme B-Complex with Methylfolate and B12, 240 Capsules | Includes coenzyme forms of B vitamins plus choline, inositol and alpha lipoic acid for energy and cognitive support - Whole Foods Market
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Oral, intravenous, or sequential alpha-lipoic acid for diabetic peripheral neuropathy? A Bayesian network meta-analysis of randomized controlled trials - Frontiers
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Mixed Results for Lipoic Acid in Multiple Sclerosis - Medscape
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Triquetra Health launches 600mg benfotiamine formula with full cofactor system for nerve support - Nutraceutical Business Review
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Alpha Lipoic Acid for Neuropathy: Does It Work? - HealthCentral
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Frishantic Launches Berberine Supplement with Ceylon Cinnamon for Daily Wellness Routines - The Manila Times
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Neuroprotective effects of α-lipoic acid on ischemia/reperfusion injury in global cerebral ischemia mouse model - Nature
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Huber Proprioceptive Training and Alpha-Lipoic Acid: A New Approach in Optimizing Nerve Function in Patients With Chronic Low Back Pain - Cureus
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α-Lipoic acid suppresses p53 by preventing annexin A2 degradation to protect dopaminergic neurons in a Parkinson's disease model - Frontiers
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Alpha-Lipoic Acid Linked to Modest Benefit in Ischemic HF - Medscape
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Successive nitric oxide and lipoic acid priming mitigates [ZnO]NPs toxicity in wheat: experimental and DFT insights - Nature
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Modulation of resting macrophage activity via low-level laser therapy (LLLT) and α-lipoic acid: an in vitro study using a PCL-based biomaterial - Nature
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The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity - Nature
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Alpha-lipoic acid reduces oxidative damage and ameliorates follicular abnormalities in vitrified cat ovarian tissue - Frontiers
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The Efficacy of Alpha-Lipoic Acid and B Vitamins in the Management of Diabetic Patients with Symptomatic Distal Symmetric Polyneuropathy: A Randomized Controlled Trial - medRxiv
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8 Best Alpha-Lipoic Acid Supplements of 2026 for Dose, Value, and Label Clarity - Fitness Volt
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Antioxidant alpha-lipoic acid may help reduce lung damage in PF - Pulmonary Fibrosis News
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Antioxidant lipoic acid slows brain atrophy in progressive MS: Study - Multiple Sclerosis News Today
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Alpha-Lipoic acid in the management of restless legs syndrome in patients with diabetic neuropathy: A possible novel therapeutic approach - springermedicine.com
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ALA for Weight Loss - View LyWVcTboo - scchr.jp
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Can Alpha Lipoic Acid Lower Blood Sugar? - View kTVZOGW5J - МГИМО
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Chilean Scientists Boost Antioxidant Levels in Tomatoes Without Affecting Plant Growth - SeedWorld
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Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging - Nature
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The impact of alpha-lipoic acid treatment on various mediators of inflammatory and immune responses in a murine arthritis model - springermedicine.com
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Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration - Frontiers
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Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis - Nature
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ADME analysis, metabolic prediction, and molecular docking of lipoic acid with SARS-CoV-2 Omicron spike protein - Nature
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6 Supplements To Help You Manage Neuropathy - health.com
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The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines - Nature
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Recyclable surgical, consumer, and industrial adhesives of poly(α-lipoic acid) - Science | AAAS
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α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation - Nature
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Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal - Nature
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A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin - Cureus
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Lipoic acid-plumbagin conjugate protects pancreatic beta cells against high glucose-induced toxicity - Nature
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Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling - Nature
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α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence - Nature
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Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy - Nature
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α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells - Nature
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α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer’s disease - Frontiers
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Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling - Nature
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Blood pressure lowering effects of alpha-lipoic acid supplementation: a meta-analysis of randomized controlled trials - Via Medica Journals
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Alpha Lipoic Acid and Cancer - Cancer Therapy Advisor
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Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone - Nature
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Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of ( R )-lipoic acid - Nature
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A-Lipoic Acid Alleviates Folic Acid-Induced Renal Damage Through Inhibition of Ferroptosis - Frontiers
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Antioxidant supplement boosts frataxin in FA cells: Study - Friedreich's Ataxia News
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Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity - Nature
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Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress - PNAS
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Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro - Nature
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Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery | Scientific Reports - Nature
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Lipoic acid attachment to proteins: stimulating new developments - ASM Journals
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Alpha-lipoic acid attenuates heat stress-induced apoptosis via upregulating the heat shock response in porcine parthenotes | Scientific Reports - Nature
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Self-Assembly of a Conjugate of Lipoic Acid With a Collagen-Stimulating Pentapeptide Showing Cytocompatibility and Wound Healing Properties, and Chemical and Photolytic Disassembly - Wiley Online Library
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Allergic contact dermatitis due to α-lipoic acid in a topical over-the-counter product: A case report - Wiley Online Library
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The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial - Nature
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Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats - Nature
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Methimazole and α-lipoic acid as metallo-β-lactamases inhibitors - Nature
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Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways - Wiley Online Library
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Sustainable polymers that stick inside and out - Science | AAAS
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Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway - Nature
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Supplementation of Alpha-lipoic acid-loaded nanoliposomes in semen extender improves freezability of buffalo spermatozoa - Nature
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Versatile Light‐Mediated Synthesis of Degradable Bottlebrush Polymers Using α‐Lipoic Acid - Wiley Online Library
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Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice - Nature
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Alleviative effects of α‐lipoic acid on muscle atrophy via the modulation of TNF‐α/JNK and PI3K/AKT pathways in high‐fat diet and streptozotocin‐induced type 2 diabetic rats - Wiley Online Library
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Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study | Scientific Reports - Nature
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Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction - Frontiers
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Tumour microenvironment-responsive lipoic acid nanoparticles for targeted delivery of docetaxel to lung cancer - Nature
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Type 2 Diabetes and Dietary Supplements: What the Science Says - National Center for Complementary and Integrative Health (.gov)
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RETRACTED ARTICLE: Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer - Nature
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Supplement’s ability to guard arteries studied - Vanderbilt Health News
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Fruit-specific overexpression of lipoyl synthase increases both bound and unbound lipoic acid and alters the metabolome of tomato fruits - Frontiers
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Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain - Frontiers
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Patients with multiple sclerosis may benefit from over-the-counter therapy - OHSU News
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Alpha-lipoic acid does not improve olfactory training results in olfactory loss due to COVID-19: a double-blind randomized trial - www.elsevier.com
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α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria - Nature
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Alpha-lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats - Wiley Online Library
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The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways - Nature
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Alpha-Lipoic Acid Skin Care Benefits, Uses, and Potential Side Effects - Healthline
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Nephro‐protective effects of alpha‐lipoic acid in type I diabetes - Wiley Online Library
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Dietary Lipoic Acid Attenuates Oxidative Stress and Retinal Ganglion Cell Loss in the DBA/2J Mouse Model of Glaucoma | IOVS | ARVO Journals - ARVO Journals
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Lipoic Acid‐Derived Bioadhesive Prepared from Rapid Molecular Aggregation - Fang - 2025 - Small - Wiley Online Library
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Lipoic Acid Restores Binding of Zinc Ions to Human Serum Albumin - Frontiers
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Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity - Wiley Online Library
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Trial testing metformin, alpha-lipoic acid in progressive MS set to start - Multiple Sclerosis News Today
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Video on Alpha-Lipoic Acid Benefits, Risks, Side Effects - WebMD
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Lipoic Acid and Multiple Sclerosis: Does It Help? - Healthline
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Renewable resource: sulfur is used, replenished to produce lipoic acid - The Pennsylvania State University
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Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice - Nature
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Development and single dose clinical pharmacokinetics investigation of novel zein assisted- alpha lipoic acid nanoencapsulation of vardenafil | Scientific Reports - Nature
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Alpha-lipoic acid helps dogs, may harm cats - PetfoodIndustry
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Dynamic Relay of Protein-Bound Lipoic Acid in Staphylococcus aureus - ASM Journals
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Could alpha lipoic acid treat polycystic ovary syndrome? - News-Medical
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L-F001, a multifunctional fasudil–lipoic acid dimer, antagonizes hypoxic–ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway - Wiley Online Library
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.