Why is "LDL receptor" trending?

Search Interest Perspective

• Drug Targets LDL Receptor Pathway to Control Cholesterol - Genetic Engineering and Biotechnology News
• The promise of vectors targeting the LDL receptor - Drug Target Review
• LDL receptor-independent mechanisms of proprotein convertase subtilisin/kexin type 9 in cardiovascular pathophysiology - Frontiers
• Genotype-guided HoFH care: Using LDLR function, genetic testing, and phenocopy workups to personalize treatment - MDLinx
• The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR - science.org
• The LDL Receptor | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• Molecular basis for LDL receptor recognition by PCSK9 - PNAS
• Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein - Nature
• LDLR Gene Variants Linked to Increased ‘Bad’ Cholesterol and Heart Attack Risk - Genetic Engineering and Biotechnology News
• Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms | Circulation Research - American Heart Association Journals
• Advances in molecular regulation and function of LDLR family in viral infection - Frontiers
• ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells - Nature
• LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus - PNAS
• Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells - Nature
• LDL Receptor–Related Protein Mediates Uptake of Aggregated LDL in Human Vascular Smooth Muscle Cells - American Heart Association Journals
• LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments - Nature
• RNF130 Adds Further Complexity to the Regulation of LDL Receptor Activity - American Heart Association Journals
• LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: - American Heart Association Journals
• Dietary Monounsaturated Fatty Acids Promote Aortic Atherosclerosis in LDL Receptor–Null, Human ApoB100–Overexpressing Transgenic Mice | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma - Nature
• Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis - Nature
• Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor - Nature
• Heparan sulfate proteoglycans present PCSK9 to the LDL receptor - Nature
• Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptor - science.org
• Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome - American Heart Association Journals
• LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy - Nature
• Structure of the LDL Receptor Extracellular Domain at Endosomal pH - science.org
• Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice - PNAS
• Oxidized LDL Modulates Bax/Bcl-2 Through the Lectinlike Ox-LDL Receptor-1 in Vascular Smooth Muscle Cells - American Heart Association Journals
• PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor - Nature
• A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state - Nature
• Effects of LDL Receptor Modulation on Lymphatic Function - Nature
• Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells - PNAS
• Pathways and Molecular Mechanisms Governing LDL Receptor Regulation | Circulation Research - American Heart Association Journals
• High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5 - NEJM
• Trib1 Deficiency Promotes Hyperlipidemia, Inflammation, and Atherosclerosis in LDL Receptor Knockout Mice - American Heart Association Journals
• LDL Receptor Identified as Surprising Potential Therapeutic Target for Alzheimer’s Disease - Genetic Engineering and Biotechnology News
• Figure 3. [LDL Receptor Pathway (figure modified from Annual Review of Biochemistry 46: 897, 1977).]. - Endotext - National Institutes of Health (NIH) | (.gov)
• The distribution and characteristics of LDL receptor mutations in China: A systematic review - Nature
• Analysis of HDL-microRNA panel in heterozygous familial hypercholesterolemia subjects with LDL receptor null or defective mutation - Nature
• The genetic and epigenetic association of LDL Receptor Related Protein 1B ( LRP1B ) gene with childhood obesity - Nature
• High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5 - NEJM
• Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation - PNAS
• Effect of γ-Irradiation and Bone Marrow Transplantation on Atherosclerosis in LDL Receptor-Deficient Mice - American Heart Association Journals
• Deconstructing the LDL receptor — a rhapsody in pieces - Nature
• CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient Mice - American Heart Association Journals
• -Cys) and ApoE3-Leiden Transgenic Mice Is Modulated Predominantly by LDL Receptor Expression - American Heart Association Journals
• A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s - Nature
• Interleukin-6 Stimulates LDL Receptor Gene Expression via Activation of Sterol-Responsive and Sp1 Binding Elements - American Heart Association Journals
• MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels - Nature
• Identification of Soluble Forms of Lectin-Like Oxidized LDL Receptor-1 - American Heart Association Journals
• Molecular Imaging of Atherosclerotic Plaques Targeted to Oxidized LDL Receptor LOX-1 by SPECT/CT and Magnetic Resonance - American Heart Association Journals
• Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites - Frontiers
• Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice - Nature
• Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice - American Heart Association Journals
• Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor - Nature
• Statins and New-Onset Diabetes Mellitus: LDL Receptor May Provide a Key Link - Frontiers
• Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice - American Heart Association Journals
• LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor - science.org
• Lrp1/LDL Receptor Play Critical Roles in Mannose 6‐Phosphate‐Independent Lysosomal Enzyme Targeting - Wiley Online Library
• Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor–Deficient Mice - American Heart Association Journals
• Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex | Scientific Reports - Nature
• LDL-receptor-related proteins in Wnt signal transduction - Nature
• JLR: Study sheds light on function of mysterious PCSK9 mutation - American Society for Biochemistry and Molecular Biology
• Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor−/− Mice - American Heart Association Journals
• Amiodarone improves anemia in a murine model of sickle cell disease and is associated with increased erythrocyte bis(monoacylglycerol) phosphate - Nature
• Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module - Nature
• Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice - Nature
• Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor - Nature
• arrow encodes an LDL-receptor-related protein essential for Wingless signalling - Nature
• Parameters of hepatic inflammation. - PLOS
• An LDL-receptor-related protein mediates Wnt signalling in mice - Nature
• Influence of LDL receptor gene mutations and the R3500Q mutation of the apoB gene on lipoprotein phenotype of familial hypercholesterolemic patients from a South European population - Nature
• Genetics of Familial Hypercholesterolemia: New Insights - Frontiers
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins - Nature
• Regulatory Adaptation of Isoprenoid Biosynthesis and the LDL Receptor Pathway in Fibroblasts from Patients with Mevalonate Kinase Deficiency - Nature
• A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis - Nature
• Mutation type classification and pathogenicity assignment of sixteen missense variants located in the EGF-precursor homology domain of the LDLR - Nature
• Heterozygous Null LDLR Mutation in a Familial Hypercholesterolemia Patient With an Atypical Presentation Because of Alcohol Abuse - American Heart Association Journals
• Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail - PNAS
• New advance announced in reducing 'bad' cholesterol - Medical Xpress
• Brown and Goldstein: The Cholesterol Chronicles - PNAS
• Looking for New Ways to Target Powerful Cholesterol-Lowering Mechanism (AHA 2016) - University of Ottawa Heart Institute
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