Why is "Kinase" trending?

Search Interest Perspective

• An AI-enabled structural atlas decodes kinase specificity across the human proteome - Nature
• Redox-dependent S-glutathionylation of Aurora-A kinase by Gstp promotes postsynaptic maturation - Rockefeller University Press
• Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer - Science | AAAS
• Design and optimization of a kinase-controlled allosteric switch - Nature
• The allosteric landscape of the Src kinase - Science | AAAS
• A sequential MAP kinase cascade regulates mechanical signalling - Nature
• Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing - Nature
• Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ - Nature
• Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies - Nature
• Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira - Nature
• The emerging role of kinase fusion proteins in cereal immunity - Nature
• A universal polyphosphate kinase powers in vitro transcription - Nature
• Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature
• Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis - Nature
• Exploring the conformational landscape of adenylate kinase and beyond with protein folding models - Nature
• Polo-like kinase Cdc5 orchestrates Cdk1 regulation via Swe1 and Mih1 during meiotic prophase I exit - Nature
• Exogenous creatine supplementation promotes tumor metastasis via megakaryocyte creatine kinase B-STAT5B signaling - Nature
• Pharmacophore-driven kinase profiling applied to the PKIS2 chemogenomic dataset - Nature
• Enhancing kinase-inhibitor activity and selectivity prediction through contrastive learning - Nature
• Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature
• Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling - Nature
• Kinase inhibitors shown to accelerate protein breakdown - Drug Target Review
• Molecular recording of cellular protein kinase activity with chemical labeling - Nature
• Tandem kinase proteins across the plant kingdom - Nature
• A web portal for exploring kinase-substrate interactions | npj Systems Biology and Applications - Nature
• Kinase drug discovery 20 years after imatinib: progress and future directions - Nature
• Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N - Nature
• Advancements in Protein Kinase Inhibitors: From Discovery to Clinical Applications - spj.science.org
• Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering - PNAS
• Trends in kinase drug discovery: targets, indications and inhibitor design - Nature
• Cellular functions of the protein kinase ATM and their relevance to human disease - Nature
• Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers - Nature
• The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature
• Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites - Nature
• Robust inference of kinase activity using functional networks - Nature
• Kinase drug discovery 20 years after imatinib - Nature
• A bi-kinase module sensitizes and potentiates plant immune signaling - Science | AAAS
• Research shows why cancer stops responding to kinase-blocking drugs and comes back stronger - U.S. National Science Foundation (.gov)
• The Protein Kinase Complement of the Human Genome - Science | AAAS
• Protein Kinase A Is a Master Regulator of Physiological and Pathological Cardiac Hypertrophy - American Heart Association Journals
• A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains - Nature
• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases - PNAS
• Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure - NEJM
• Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I - ScienceDirect.com
• Subcellular partitioning of protein kinase activity revealed by functional kinome profiling - Nature
• p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD - PNAS
• De novo design of tyrosine and serine kinase-driven protein switches - Nature
• Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology - Nature
• Targeting cancer with small molecule kinase inhibitors - Nature
• Discovering the first tyrosine kinase - PNAS
• Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis - NEJM
• Protein kinase C controls lysosome biogenesis independently of mTORC1 - Nature
• Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1 - PNAS
• PAS kinase: An evolutionarily conserved PAS domain-regulated serine/threonine kinase - PNAS
• Deep learning enables rapid identification of potent DDR1 kinase inhibitors - Nature
• The membrane-localized protein kinase MAP4K4/TOT3 regulates thermomorphogenesis - Nature
• S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions - Nature
• Reversible control of kinase signaling through chemical-induced dephosphorylation - Nature
• Protein kinase C, an elusive therapeutic target? - Nature
• Revisiting protein kinase–substrate interactions: Toward therapeutic development - Science | AAAS
• The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance - PNAS
• Discovery of effectors for casein kinase signaling in the African trypanosome | Scientific Reports - Nature
• High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching - Nature
• Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells - PNAS
• A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane - PNAS
• A dynamically coupled allosteric network underlies binding cooperativity in Src kinase - Nature
• Auto-phosphorylation Represses Protein Kinase R Activity - Nature
• Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties - PNAS
• RedOx regulation of LRRK2 kinase activity by active site cysteines - Nature
• A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation - Nature
• Targets mapped for almost all human kinase enzymes - Nature
• Activation of the essential kinase PDK1 by phosphoinositide-driven trans -autophosphorylation - Nature
• Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90 - PNAS
• Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco - PNAS
• Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway - PNAS
• Kinase mutations in human disease: interpreting genotype–phenotype relationships - Nature
• Evidence that phytochrome functions as a protein kinase in plant light signalling - Nature
• The protein kinase CK1: Inhibition, activation, and possible allosteric modulation - Frontiers
• Comprehensive characterization of the Published Kinase Inhibitor Set - Nature
• Rational Design of a Protein Kinase A Nuclear-cytosol Translocation Reporter - Nature
• A chemical switch for inhibitor-sensitive alleles of any protein kinase - Nature
• Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1 - Nature
• Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates - PNAS
• Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression - PNAS
• Selective inhibition of the kinase DYRK1A by targeting its folding process - Nature
• Mechanoenzymatics of titin kinase - PNAS
• Pim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration - Nature
• Local protein kinase A action proceeds through intact holoenzymes - Science | AAAS
• Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain - PNAS
• Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase - PNAS
• Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells - PNAS
• A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling - PNAS
• Protein kinases: drug targets for immunological disorders - Nature
• Transitions to catalytically inactive conformations in EGFR kinase - PNAS
• Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit - PNAS
• The Phosphoinositide 3-Kinase Pathway - Science | AAAS
• Protein kinase CK2 as an ectokinase: The role of the regulatory CK2β subunit - PNAS
• Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources - Nature
• Tyrosine kinases in extracellular space - Nature
• Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3 - Nature