Why is "Isoniazid" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-11 08:38:23
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Isoniazid entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-11 and was most recently seen on 2026-04-11.
Wikipedia Overview
Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis, it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. It may also be used for atypical types of mycobacteria, such as M. avium, M. kansasii, and M. xenopi. It is usually taken by mouth, but may be used by injection into muscle.
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A Rare Case of Isoniazid Induced Pancreatitis : American Journal of Gastroenterology - Lippincott Home
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Lineage-Dependent IFN-γ Responses to Drug-Sensitive and Isoniazid Mon | IDR - dovepress.com
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Isoniazid subverting erythrocyte homeostasis: implications for tuberculosis therapy - Frontiers
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Melting temperature signatures reveal occasional misclassification of low-level isoniazid resistance by Xpert MTB/XDR - ASM Journals
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Isoniazid and rifampicin induced fever in a... : Saudi Journal for Health Sciences - ovid.com
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A Review on Isoniazid and Rifampicin-Associated Hepatotoxicity: From Metabolism to Immunity - Wiley Online Library
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Isoniazid-associated pellagra during mass scale-up of tuberculosis preventive therapy: a case-control study - The Lancet
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Time to Sputum Culture Conversion and the Intensive Phase Treatment Outcomes in South African Patients with Isoniazid Mono-resistant Tuberculosis - European Society of Medicine
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Tuberculosis: Common Questions and Answers - American Academy Of Family Physicians | AAFP
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One Versus Three: Federally Funded Clinical Trial Shows Daily Meds for a Month Comparable to Once Weekly for Three Months to Treat TB - Johns Hopkins Medicine
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Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates - ASM Journals
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Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women - nejm.org
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Isoliquiritigenin, Nrf2 Activator, and NLRP3 Inhibitor Protects Isoniazid-Induced Hepatotoxicity in Sprague-Dawley Rats: Studies on Oxidative Stress, Inflammation, DNA Damage, Ferroptosis, and Steatosis - Wiley Online Library
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Mechanisms of action of isoniazid : Molecular Microbiology - ovid.com
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The MAB_3513c gene plays a key role in intrinsic resistance of Mycobacterium abscessus to isoniazid and ethionamide - ASM Journals
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A rare case of isoniazid mono-resistant... : Lung India - ovid.com
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iFIND INH/FQ: a LC-aNAAT assay for rapid simultaneous detection of isoniazid and fluoroquinolone resistance in Mycobacterium tuberculosis - ASM Journals
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Analysis of nationwide adverse event reports on Isoniazid and Rifampin in tuberculosis prevention and treatment in South Korea - nature.com
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Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults - nejm.org
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Shorter treatment regimens are safe options for preventing active tuberculosis - EurekAlert!
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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity | Experimental & Molecular Medicine - nature.com
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Technical Report on critical concentrations for drug susceptibility testing of isoniazid and the rifamycins (rifampicin, rifabutin and rifapentine) - World Health Organization (WHO)
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One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis - nejm.org
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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis - ASM Journals
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5 Isoniazid Side Effects You Should Know About - GoodRx
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8 Isoniazid Interactions to Watch Out For - GoodRx
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Improved detection of isoniazid-heteroresistant Mycobacterium tuberculosis subpopulations by droplet digital PCR compared to MeltPro TB assay - ASM Journals
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Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis - nature.com
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Safety and Side Effects of Rifampin versus Isoniazid in Children - nejm.org
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Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection - nejm.org
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Isoniazid preventive therapy modulates Mycobacterium tuberculosis -specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes - nature.com
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A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa - nejm.org
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Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients | Scientific Reports - nature.com
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Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid - nature.com
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TB Today: Short Course, Long Problems - Medscape
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Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations - nature.com
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Linking lipid profile alterations to antibiotic tolerance and natural product synergy in drug-resistant Mycobacterium tuberculosis clinical isolates - nature.com
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Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site - nature.com
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Adherence to nine-month isoniazid for latent tuberculosis infection in healthcare workers: a prospective study in a tertiary hospital - nature.com
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A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control - nejm.org
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Comparison Finds Rifampin Superior in Cost, Safety to Isoniazid for Latent Tuberculosis - Infectious Disease Advisor
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Rifampicin and isoniazid drug resistance among patients diagnosed with pulmonary tuberculosis in southwestern Uganda - pubmed.ncbi.nlm.nih.gov
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Taking isoniazid preventive therapy (IPT) during pregnancy not associated with adverse birth outcomes - Aidsmap
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Tuberculosis Drug Supply Interruptions and Shortages - Centers for Disease Control and Prevention | CDC (.gov)
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Hydrothermal Synthesize of HF-Free MIL-100(Fe) for Isoniazid-Drug Delivery - nature.com
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Anti‐Tubercular Drug‐Induced Liver Injury : JGH Open - ovid.com
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Weekly rifapentine plus isoniazid for 3 months is safe for latent TB infection - European AIDS Treatment Group
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The ahpC c−54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis - ASM Journals
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Encapsulation of Isoniazid-conjugated Phthalocyanine-In-Cyclodextrin-In-Liposomes Using Heating Method - nature.com
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Primary Isoniazid Prophylaxis against Tuberculosis in HIV-Exposed Children - nejm.org
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Spontaneous abortion in women with HIV linked to isoniazid exposure in pregnancy - European AIDS Treatment Group
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Adverse Events During TB Treatment - Centers for Disease Control and Prevention | CDC (.gov)
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Identification of a mycobacterial hydrazidase, an isoniazid-hydrolyzing enzyme - nature.com
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Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis : Genes, Mutations, and Causalities - ASM Journals
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Rifampicin May Be Safer Than Isoniazid in Latent Tuberculosis Treatment - Infectious Disease Advisor
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Population Pharmacokinetics and Pharmacodynamics of Isoniazid and its Metabolite Acetylisoniazid in Chinese Population - Frontiers
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Study Becomes First to Demonstrate Efficacy of Topical Isoniazid in Melasma - Dermatology Times
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Association between 9-month isoniazid prophylaxis of latent tuberculosis and severe hepatitis in patients treated with TNF inhibitors - nature.com
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Studies on Isoniazid Derivatives through a Medicinal Chemistry Approach for the Identification of New Inhibitors of Urease and Inflammatory Markers - nature.com
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The use of molecular line probe assay for the detection of resistance to isoniazid and rifampicin - World Health Organization (WHO)
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An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis - nature.com
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Isoniazid-Induced Acute Liver Failure Requiring Liver Transplantation - Cureus
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A Case of Isoniazid-Induced Delirium - Psychiatry Online
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Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India - nature.com
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Safety and Side Effects of Rifampin versus Isoniazid in Children - nejm.org
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Development of a gradient method for sulfamethoxazole, trimethoprim, isoniazid, and pyridoxine hydrochloride in rabbit plasma through QbD-driven investigation - nature.com
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Ethambutol/isoniazid/levofloxacin/rifampicin - Springer Nature Link
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Evaluation of centralized assays for TB detection and detection of resistance to rifampicin and isoniazid - World Health Organization (WHO)
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Development of isoniazid electrochemical sensor using nickel ferrite - nitrogen and sulfur co-doped graphene quantum dot nanocomposite as a new electrode modifier - nature.com
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Gallein potentiates isoniazid's ability to suppress Mycobacterium tuberculosis growth - Frontiers
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Comparison of 3 Preventive Tuberculosis Therapies in Patients With HIV Infection - Infectious Disease Advisor
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Latent TB Infection Treatment: 4 Months of Rifampin vs 9 Months of Isoniazid - Pulmonology Advisor
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Primary Isoniazid Mono-Resistant Extrapulmonary Tuberculosis Presenting as Cervical Lymphadenitis: The World’s First Case of Its Type - Cureus
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New genetics tool helps guide dosages of tuberculosis drug - Stanford Medicine
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Clinical characteristics of isoniazid-induced liver injury - British Pharmacological Society | Journals
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InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG - nature.com
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Rifampin viable as an alternative to isoniazid treatment for latent tuberculosis - 2minutemedicine.com
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Tuberculosis Treatment and Case Outcomes - Centers for Disease Control and Prevention | CDC (.gov)
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Initiation of Isoniazid Prophylactic Therapy among Newly Diagnosed HIV-Positive Persons in Three High HIV-Burden Districts of South Africa - SCIRP Open Access
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Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis - nejm.org
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Early Bactericidal Activity of High-Dose Isoniazid for Drug Resistant TB - Infectious Disease Advisor
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Isoniazid-Associated Serotonin Toxicity in the Critical Care Setting: A Case Report - Cureus
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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis - ASM Journals
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A biphasic nanohydroxyapatite/calcium sulphate carrier containing Rifampicin and Isoniazid for local delivery gives sustained and effective antibiotic release and prevents biofilm formation - nature.com
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Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial - The Lancet
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Population Pharmacokinetic Analysis of Isoniazid, Acetylisoniazid, and Isonicotinic Acid in Healthy Volunteers - ASM Journals
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Isoniazid hepatitis: are immunological mechanisms implicated? - www.elsevier.com
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Alpibectir-Ethionamide Safe for TB, With Similar Activity to Isoniazid - MedPage Today
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Drug-Resistant Tuberculosis Disease - Centers for Disease Control and Prevention | CDC (.gov)
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New Regimens to Prevent Tuberculosis in Adults with HIV Infection - nejm.org
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Preventive Effects of Isoniazid in the Treatment of Primary Tuberculosis in Children - nejm.org
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Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin - nature.com
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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy - nature.com
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Single Nucleotide Polymorphisms in Genes Associated with Isoniazid Resistance in Mycobacterium tuberculosis - ASM Journals
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6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial - The Lancet
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Isoniazid overdose - First10EM
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Isoniazid - chemistryworld.com
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Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis - nature.com
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Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test - nature.com
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Isoniazid Induced Pure Red Blood Cell Aplasia - Cureus
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.