Why is "Homogentisate 1,2-dioxygenase" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-21 08:08:46
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Homogentisate_1,2-dioxygenase entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-21 and was most recently seen on 2026-05-21.
Wikipedia Overview
Homogentisate 1,2-dioxygenase (homogentisic acid oxidase, homogentisate oxidase, homogentisicase) is an enzyme which catalyzes the conversion of homogentisic acid to 4-maleylacetoacetic acid. Homogentisate 1,2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the amino acids tyrosine and phenylalanine. HGD appears in the metabolic pathway of tyrosine and phenylalanine degradation once the molecule homogentisate is produced. Homogentisate reacts with HGD to produce maleylacetoacetate, which then is further used in the metabolic pathway. HGD requires the use of Fe2+ and O2 in order to cleave the aromatic ring of homogentisate.
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Trending Topic Today
Search Interest Perspective
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Tyrosinase drives hydroquinone-induced exogenous ochronosis: not HGD inhibition - EurekAlert!
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Homogentisate 1,2-dioxygenase ( HGD ) gene variants in young Egyptian patients with alkaptonuria - Nature
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Single Amino Acid Substitution in Homogentisate Dioxygenase Affects Melanin Production in Bacillus thuringiensis - Frontiers
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Natural History of Alkaptonuria - The New England Journal of Medicine
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A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria | Scientific Reports - Nature
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FDA Approves Harliku for Patients With Alkaptonuria - Renal and Urology News
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Pseudomonas putida CSV86: A Candidate Genome for Genetic Bioaugmentation - PLOS
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Researchers challenge old mechanism behind skin discoloration from hydroquinone - Medical Xpress
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Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU - Nature
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A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria - Nature
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Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics - Nature
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Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’ in Italy - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.