Why is "Hirschsprung's disease" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-31 17:41:03
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Hirschsprung's_disease entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-31 and was most recently seen on 2026-05-31.
Wikipedia Overview
Hirschsprung's disease is a birth defect in which nerves are missing from parts of the intestine. The most prominent symptom is constipation. Other symptoms may include vomiting, abdominal pain, diarrhea and slow growth. Most children develop signs and symptoms shortly after birth. However, others may be diagnosed later in infancy or early childhood. About half of all children with Hirschsprung's disease are diagnosed in the first year of life. Complications may include enterocolitis, megacolon, bowel obstruction and intestinal perforation.
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Trending Topic Today
Search Interest Perspective
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Localized Eosinophilic Ileitis Presenting As Refractory Pediatric Intestinal Pseudo-Obstruction With Recurrent Ileostomy Prolapse: A Delayed Histopathologic Diagnosis - Cureus
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Intra-operative application of ultra-high frequency ultrasound facilitates differentiation of bowel wall characteristics between ganglionic and aganglionic segments during transanal endorectal pull-through for Hirschsprung disease - Nature
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New stem cell therapy offers permanent cure for Hirschsprung disease - News-Medical
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On the horizon: stem cell therapy for Hirschsprung disease - Hospital Healthcare Europe
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Surgical decision making in late-presenting Hirschsprung's disease: direct pull-though or stoma first - Frontiers
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NeoQuest March 2026: A Newborn With Persistent Abdominal Distension - AAP
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A Case of Chronic Idiopathic Megacolon : American Journal of Gastroenterology - Lippincott Home
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ACS Award Helps Pioneer Treatment for Congenital Colorectal Disease - The American College of Surgeons
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The Barium-Enema Examination and Rectal Manometry in Hirschsprung DiseaseRadiology - RSNA Journals
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Newborn With Enlarged Bowel - American Academy Of Family Physicians | AAFP
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Megacolon: When constipation becomes something more serious - Medical Xpress
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Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial - Nature
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Mid-ureteric Ectasia Masquerading as Hirschsprung Disease: A Rare Cause of Infantile Large Bowel Obstruction - Cureus
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A multi-gene mouse model reveals new mechanisms of Hirschsprung disease - News-Medical
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Gastrointestinal dysfunction in patients with Mowat–Wilson syndrome is associated with feeding difficulties and altered plasma neurotransmitters - Frontiers
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Perioperative outcomes in primary neonatal pullthrough versus pullthrough in older children with Hirschsprung disease: a systematic review and meta-analysis - Nature
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Goldberg-Shprintzen Megacolon Syndrome Diagnosed in the Neonatal Period: A Case Report With Molecular Confirmation - Cureus
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Crohn's Disease Developing After Hirschsprung's Disease in a Child With Down Syndrome: A Rare Clinical Overlap - Cureus
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Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling - Nature
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A Case of Peutz-Jeghers Syndrome Complicated With Hirschsprung Disease - Cureus
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Maine family struggles as toddler battles rare disease: ‘A long road' - Seacoastonline.com
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CCHS: Hirschsprung disease flags markedly higher mortality risk - Vera Health
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Necrotizing Enterocolitis in a Term Newborn With Hypoxic-Ischemic Encephalopathy - Cureus
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Refining the Sox10Dom/+ mouse model: A new breeding strategy with relevance to Hirschsprung disease genetics - Wiley Online Library
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Impact of preoperative bowel preparation methods on anastomotic leakage and intestinal motility recovery in laparoscope-assisted heart-shaped anastomosis - Frontiers
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Mixed candidemia in a pediatric patient with Hirschsprung's disease - www.elsevier.com
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Clues offer new hope for treating GI tract disorders - Vanderbilt Health News
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Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non-genetic Model to Study Hirschsprung Disease? - Wiley Online Library
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Hirschprung's Disease and Thoracic Limb Amputation by Amniotic Bands in a Patient With Down Syndrome: A Case Report - Wiley Online Library
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Stem cell-based therapy for hirschsprung disease, do we have the guts to treat? - Nature
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Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis - Science | AAAS
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Expression of BCL-2 and Laminin in Rectosigmoid Hirschsprung Disease: Correlations with Hirschsprung−Associated Enterocolitis - Nature
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Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation - Nature
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Molecular Genetic Anatomy and Risk Profile of Hirschsprung’s Disease - The New England Journal of Medicine
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Hirschsprung Disease: One Mother’s Story of Her Newborn’s Rare Disease - UVA Health
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Identification of ulcerative colitis diagnostic markers from differentially expressed genes shared with Hirschsprung disease - Nature
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Establishment and identification of an animal model of Hirschsprung disease in suckling mice - Nature
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Chronic Constipation Unmasking as Hirschsprung Disease in a Preadolescent: Delayed Presentation or Delayed Diagnosis? - Cureus
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Colonic Derotation Revisited: The "Deloyers Procedure" for Long-Segment Hirschsprung Disease - Cureus
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Anorectal malformation combined with Hirschsprung's disease: a case report - Frontiers
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Jersey Shore Team Treats Newborn With Hirschsprung Disease - Hackensack Meridian Health
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Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease - Nature
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Deciphering the complexity of enteric niches in Hirschsprung disease: from metaphorical insights to therapeutic transformation - Frontiers
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Sphincter reconstruction offers new hope for children with Hirschsprung disease - Children's National
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Hirschsprung Disease and Intestinal Neuronal Dysplasia Type B: Is There a Difference in the Clinical Presentation of These Two Diseases? - Cureus
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Hirschsprung’s Disease in Adults Revealed by an Occlusive Syndrome - Cureus
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Editorial: Hirschsprung disease: genetic susceptibility, disease mechanisms and innovative management in the multi-omics era - Frontiers
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Early promise of sphincter reconstruction for Hirschsprung disease - Children's National
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Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing - Nature
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Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence - Wiley Online Library
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Diagnosing Hirschsprung disease by detecting intestinal ganglion cells using label-free hyperspectral microscopy - Nature
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For short-segment Hirschsprung disease, daily trans-anal irrigation before pull-through surgery is necessary? - Nature
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Study on the application of optical coherence microscopy in Hirschsprung's disease - Nature
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Comparing surface electroenterography measurements between patients suffering from Hirschsprung’s disease and controls: a feasibility study - Nature
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Mutations in Hirschsprung Disease: When Does a Mutation Contribute to the Phenotype - Nature
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Hirschsprung’s Disease: Luke's Story - Children's Hospital of Philadelphia
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Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease - Nature
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Severe colonic distention and malnutrition in a 6-week-old infant: a case of Hirschsprung-associated enterocolitis - The Lancet
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A Case Report of Hirschsprung’s Disease in a Neonate: Early Detection and Review of Management - Cureus
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Ileal atresia and total colonic hirschsprung disease in a 36‐week neonate: A case report - Wiley Online Library
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Disparities in the gut metabolome of post-operative Hirschsprung's disease patients - Nature
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circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung’s disease - Nature
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Better standardized care for total colonic Hirschsprung disease - Children's National
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Post-surgical Outcomes of Different Surgical Techniques in Hirschsprung’s Disease: A Literature Review - Cureus
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Adult Zonal Hirschsprung's Disease: A Diagnostic Challenge - The American College of Surgeons
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Delaying surgery for Hirschsprung disease may be risky - Contemporary Pediatrics
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Atypical Presentation of Hirschsprung's Disease in an Infant: Challenges in Early Diagnosis and Management of Recurrent Enterocolitis - Cureus
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A Rare Case Report on Postoperative Rehabilitation in Hirschsprung Disease - Cureus
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Is There Any Mosaicism in REarranged During Transfection Variant in Hirschsprung Disease’s Patients? - Frontiers
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Diagnostic accuracy of barium enema versus full-thickness rectal biopsy in children with clinically suspected Hirschsprung's disease: A comparative cross-sectional study - Wiley Online Library
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Minimally Invasive Surgery for Hirschsprung Disease: Current Practices and Future Directions - Cureus
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Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung’s disease - Nature
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Gut microbiota-mediated Gene-Environment interaction in the TashT mouse model of Hirschsprung disease - Nature
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Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis - Frontiers
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Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis - Nature
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Sotos syndrome associated with Hirschsprung’s disease: a new case and exome-sequencing analysis - Nature
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Colorectal surgeons ensure recognition for surgical innovation of Dr. Asa Yancey - Children's National
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A human model for multigenic inheritance: Phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus - PNAS
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FDA Grants ODD and RPDD to NEU-001 for Patients With Hirschsprung Disease - Pharmacy Times
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Jeddah hospital in Saudi Arabia achieves medical milestone: Robots take over paediatric surgery to treat - The Times of India
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Rare Gut Condition a Model for Study of Genetic Diseases - NYU Langone Health
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Stem Cell Technology Shows Promise for Rare Intestinal Disease - RegMedNet
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Usefulness of Delayed Films of Contrast Enema for Detecting Hirschsprung’s Disease - Cureus
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Minimally invasive surgery in older children with Hirschsprung’s disease in a North African Country - Frontiers
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Gosain Receives $2.1 M Grant for Hirschprung Enterocolitis Research - UTHSC News
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Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single-cell RNA sequencing - Wiley Online Library
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New-Onset Seizures in Infant With Square Facies, Hypospadias, and Hirschsprung Disease - Contemporary Pediatrics
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Hirschsprung Disease and Hypoganglionosis in Adults: Radiologic Findings and Differentiation - RSNA Journals
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Gene therapy research offers hope for kids with life-altering condition - WCVB
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Stem cell therapy shows promise for hirschsprung disease - Open Access Government
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Effects of RET, NRG1 and NRG3 Polymorphisms in a Chinese Population with Hirschsprung Disease - Nature
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Hirschsprung disease associated with maternal obesity and preterm birth - 2 Minute Medicine
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Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models | Scientific Reports - Nature
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Scientists Add Nerves to Intestinal Organoids - Research Horizons
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First-of-its-kind surgical procedure offers new hope for children with Hirschsprung disease - Medical Xpress
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Hirschsprung Disease and Hypoganglionosis in Adults: Radiologic Findings and Differentiation - RSNA Journals
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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease - Nature
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Hirschprung’s disease won’t stop Myles from smiling - Boston Children's Answers
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Aberrant Development of Enteric Glial Cells in the Colon of Hirschsprung's Disease - Frontiers
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Treating Hirschsprung’s Disease and Anorectal Malformation With Swenson Pull-Through - Physician's Weekly
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.