Why is "HMG-CoA reductase" trending?

Search Interest Perspective

• Structural Mechanism for Statin Inhibition of HMG-CoA Reductase - Science | AAAS
• More Than Muscle Aches: A Case of Statin-Associated Necrotizing Myositis - Cureus
• HMGCR: a malignancy hub - frontiers in cancer diagnosis and therapy - Frontiers
• Inflammation, Immunity, and HMG-CoA Reductase Inhibitors: - American Heart Association Journals
• Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain - Nature
• Lichenoid Drug Eruption with HMG-CoA Reductase... : Acta Dermato-Venereologica - Ovid
• Pearls & Oy-sters: Managing Cholesterol in a Patient With Statin Intolerance Due to Anti-HMG-CoA Reductase–Associated Myopathy - Neurology® Journals
• Discovery of Natural Potent HMG‐CoA Reductase Degraders for Lowering Cholesterol - Wiley Online Library
• Statin-Associated Immune-Mediated Necrotizing Myopathy With Dual Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (Anti-HMGCR) and Anti-OJ Positivity: A Case Report of Fulminant Weakness and Respiratory Failure - Cureus
• Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol - Nature
• HMG-CoA Reductase Inhibitors Suppress Intracellular Calcium Mobilization and Membrane Current Induced by Lysophosphatidylcholine in Endothelial Cells - American Heart Association Journals
• Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor - Nature
• Statin-Induced Necrotizing Autoimmune Myositis Presenting With Progressive Limb-Girdle Weakness Following Low-Dose Atorvastatin Use - Cureus
• Effects of HMG-CoA Reductase Inhibitors on Endothelial Function: - American Heart Association Journals
• A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action - Nature
• HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study - Nature
• Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase - Nature
• HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival - Nature
• Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors - Nature
• Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients - Nature
• Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice - Nature
• HMG-CoA Reductase Inhibitors Reduce MMP-9 Secretion by Macrophages - American Heart Association Journals
• miR-139-5p activates ferroptosis by inhibiting the expression of HMG-CoA reductase to inhibit the progression of glioma - Nature
• Clinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathy - Nature
• Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG-CoA Reductase—A Review - SCIRP Open Access
• Chronic Anti-HMG-CoA Reductase Positive Necrotizing Myositis With Remote Exposure to Statins - Cureus
• Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function - ScienceDirect.com
• Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase - PNAS
• 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy - PNAS
• HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway - Nature
• The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. - Nature
• HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis - JACC Journals
• Antiinflammatory and Antiarteriosclerotic Actions of HMG-CoA Reductase Inhibitors in a Rat Model of Chronic Inhibition of Nitric Oxide Synthesis - American Heart Association Journals
• The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease - Nature
• arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase - PNAS
• The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease - Nature
• New and novel treatments for hyperlipidemia - Mayo Clinic
• HMG CoA reductase inhibitor (statin) and aortic valve calcium - The Lancet
• Pitavastatin: a different pharmacological profile : Clinical Lipidology - Ovid
• Study Finds HMGCR Variants Associated With Increased Risk of Cataracts - The American Journal of Managed Care
• Feedback Regulation of Cholesterol Biosynthesis : - American Heart Association Journals
• HMG-CoA reductase from Camphor Tulsi ( Ocimum kilimandscharicum ) regulated MVA dependent biosynthesis of diverse terpenoids in homologous and heterologous plant systems - Nature
• HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis - Frontiers
• Simvastatin Inhibits Leukocyte–Endothelial Cell Interactions and Protects Against Inflammatory Processes in Normocholesterolemic Rats | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway - Nature
• Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase - Nature
• Effect of HMG-CoA Reductase Inhibitors on Coronary Artery Disease as Assessed by Electron-Beam Computed Tomography - The New England Journal of Medicine
• Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans - PNAS
• Effects of Statins on Endothelium and Signaling Mechanisms - American Heart Association Journals
• The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: A proposal as a therapeutic target and as a study model - www.elsevier.com
• A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus - Nature
• HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis - Nature
• Influence of Pravastatin, a Specific Inhibitor of HMG-CoA Reductase, on Hepatic Metabolism of Cholesterol - The New England Journal of Medicine
• Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors - American Heart Association Journals
• HMG-CoA reductase inhibitors/paracetamol - Springer Nature Link
• Beyond the Laboratory: - American Heart Association Journals
• Statin therapy inhibits fatty acid synthase via dynamic protein modifications - Nature
• Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death - American Heart Association Journals
• Diet Can Trigger Severe Myopathy Often Blamed on Statins - MedPage Today
• 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity - Journal of Neuroscience
• HMG-CoA Reductase Inhibitors and Stroke Risk - American Academy Of Family Physicians | AAFP
• HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes - Nature
• HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia - The New England Journal of Medicine
• Statin use, HMGCR expression, and breast cancer survival – The Malmö Diet and Cancer Study - Nature
• Inflammation, coronary plaque progression, and statin use: A secondary analysis of the Risk Stratification with Image Guidance of HMG CoA Reductase Inhibitor Therapy (RIGHT) study - Scott - 2022 - Clinical Cardiology - Wiley Online Library
• Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors - Springer Nature Link
• Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductases | Journal of Bacteriology - ASM Journals
• Characterization and functional analysis of two novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase genes ( GbHMGR2 and GbHMGR3 ) from Ginkgo biloba - Nature
• HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage - Wiley & Sons
• In Vivo Anti-Inflammatory Effect of Statins Is Mediated by Nonsterol Mevalonate Products - American Heart Association Journals
• 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis - Nature
• Pharmacophore generation and atom-based 3D-QSAR of N-iso-propyl pyrrole-based derivatives as HMG-CoA reductase inhibitors | Organic and Medicinal Chemistry Letters - Springer Nature Link
• Immune-Mediated Necrotizing Myopathy With Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibodies Following Viral Infection and Without Association With Statin Use: A Case Report - Cureus
• Statin Induced Autoimmune Necrotizing Myopathy (SIANM): An Alarming Adverse Event of a Familiar Medication - Cureus
• Discovery of the cellular and molecular basis of cholesterol control - PNAS
• Statin-Associated Necrotizing Autoimmune Myopathy: Unmasking 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody-Positive Disease After Statin Re-exposure - Cureus
• The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway - PNAS
• Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells | Circulation - American Heart Association Journals
• America’s Most Popular Drug Has a Puzzling Side Effect. We Finally Know Why. - The Atlantic
• Revealing a notable interaction in the binding of type II statins to HMG-CoA reductase: Stacked cation– π interaction - Wiley Online Library
• Statin-Induced Necrotizing Autoimmune Myositis: Diagnosis and Management - Cureus
• Statin Treatment in Patients With Intracerebral Hemorrhage - American Heart Association Journals
• The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins - Frontiers
• Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking - Dove Medical Press
• Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities - Nature
• Molecular mechanisms underlying the cholesterol-lowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin - Nature
• Statins: 50 years old and with new surprises in store - Tidsskrift for Den norske legeforening
• 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate β-Amyloid-Induced Microglial Inflammatory Responses - Journal of Neuroscience
• JLR: What controls cholesterol biosynthesis? - American Society for Biochemistry and Molecular Biology
• Squalene and cholesterol in the balance at the ER membrane - PNAS
• Regulatory Adaptation of Isoprenoid Biosynthesis and the LDL Receptor Pathway in Fibroblasts from Patients with Mevalonate Kinase Deficiency - Nature
• Cholesterol-lowering gene changes may increase the risk of cataracts - www.heart.org
• Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins - Nature
• Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes - Wiley Online Library
• The role of statins as potential targets for bone formation - Springer Nature Link
• HMG-CoA reductase pathway - doccheck.com
• Immune-mediated necrotising inflammatory myopathy. A rare side effect of statins - www.elsevier.com