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The second season of the American television medical drama Grey's Anatomy commenced airing on the American Broadcasting Company (ABC) channel on September 25, 2005, and concluded on May 15, 2006. Shonda Rhimes was the series' showrunner and executive producer. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T. R. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley respectively. Previous main cast members Chandra Wilson, James Pickens, Jr., Isaiah Washington and Patrick Dempsey also returned, while Kate Walsh, who began the season in a recurring capacity, was promoted to series-regular status.
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