Why is "Geldanamycin" trending?

Search Interest Perspective

• Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus - Nature
• Geldanamycin Combination with Colcemid Induces Mitotic Arrest through Stabilization of bubR1 Mitotic Kinase in Human Tumor Cells - SCIRP Open Access
• Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore - PNAS
• Induction of Premature Senescence by Hsp90 Inhibition in Small Cell Lung Cancer - PLOS
• A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90 - Nature
• Antibody-drug conjugates payloads: then, now and next - Drug Target Review
• Undergraduate student presents cancer research at global conference - UToledo News
• Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance - ASM Journals
• GdmRIII, a TetR Family Transcriptional Regulator, Controls Geldanamycin and Elaiophylin Biosynthesis in Streptomyces autolyticus CGMCC0516 - Nature
• Targeting Oncoprotein Stability Overcomes Drug Resistance Caused by FLT3 Kinase Domain Mutations - PLOS
• New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus - Nature
• Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin - Nature
• Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis - Nature
• First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 - Nature
• Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs - Nature
• The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy - Nature
• Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells - Nature
• Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9 - Nature
• HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1 - Nature
• Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion - Nature
• HSP90s are required for hypocotyl elongation during skotomorphogenesis and thermomorphogenesis via the COP1–ELF3–PIF4 pathway in Arabidopsis - Wiley
• Methanethiol as a catabolite of methionine provides methylthio- group for chemical formation of 19-S-methylgeldanamycin and 17,19-dimethylthioherbimycin A | The Journal of Antibiotics - Nature
• Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy | Experimental & Molecular Medicine - Nature
• Exploring the specialized metabolome of the plant pathogen Streptomyces sp. 11-1-2 - Nature
• Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome - Nature
• Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules - Nature
• HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis - PNAS
• Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells - PLOS
• Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90 - The EMBO Journal - Springer Nature Link