Why is "GRB2" trending?

Search Interest Perspective

• Structural and mechanistic insights into the constitutive Themis–Grb2 complex in T cell signalling - Nature
• Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex | mBio - ASM Journals
• Correction: GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway - Nature
• LY6D Drives Liver Fat Through GRB2-AMPK Pathway - Bioengineer.org
• GRB2 enforces homology-directed repair initiation by MRE11 - Science | AAAS
• GRB2 nucleates T cell receptor–mediated LAT clusters that control PLC-γ1 activation and cytokine production - Frontiers
• Specificity and affinity motifs for Grb2 SH2-ligand interactions - PNAS
• Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction - American Heart Association Journals
• Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses - Frontiers
• Grb2 binding induces phosphorylation-independent activation of Shp2 - Nature
• GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization - Nature
• GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer - Nature
• GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production - Nature
• GRB2 is a BECN1 interacting protein that regulates autophagy - Cell Death & Disease - Nature
• Grb2 monomer–dimer equilibrium determines normal versus oncogenic function - Nature
• The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation - Nature
• Regulation of microRNA expression by the adaptor protein GRB2 - Nature
• GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway - Nature
• A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer - Nature
• Scientists reveal how developing immune cells fine-tune their signals - press.vib.be
• MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells - Nature
• Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2 - Nature
• LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation - Nature
• FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl - PNAS
• TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria -transformed macrophages - Nature
• Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells - Nature
• DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2 - Nature
• NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization | Oncogene - Nature
• Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes - PNAS
• Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis - Nature
• The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module - Nature
• Scientists uncover workings of “batons” in biomolecular relay inside cells - EurekAlert!
• Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1 - Nature
• Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells - Nature
• Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR - Nature
• Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes - PNAS
• Disruption of T cell signaling networks and development by Grb2 haploid insufficiency - Nature
• Grb2, a Double-Edged Sword of Receptor Tyrosine Kinase Signaling - Science | AAAS
• Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor - Nature
• NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells - Nature
• The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin β1 - Science | AAAS
• Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion - Nature
• Coupling of protein condensates to ordered lipid domains determines functional membrane organization - Science | AAAS
• Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways - PNAS
• Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2 - Nature
• Signal transduction by GRB2 and SOS1. (IMAGE) - EurekAlert!
• Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells - Nature
• Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction - PNAS
• EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions - Rockefeller University Press
• Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes - Nature
• Differential Roles of Grb2 and AP‐2 in p38 MAPK‐ and EGF‐Induced EGFR Internalization - Grandal - 2012 - Traffic - Wiley Online Library
• Mapping the allosteric network within a SH3 domain - Nature
• Kinetic frustration by limited bond availability controls the LAT protein condensation phase transition on membranes - Science | AAAS
• Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line | Communications Biology - Nature
• Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction - Nature
• Systems and computational analysis of gene expression datasets reveals GRB-2 suppression as an acute immunomodulatory response against enteric infections in endemic settings - Frontiers
• Positive Versus Negative Signaling of LET-23: Regulation Through the Adaptor Protein, SEM-5 - Science | AAAS
• TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps - Nature
• Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells - Nature
• Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis - Nature
• Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1 - Nature
• Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase - Nature
• Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling - Nature
• Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2 - Nature
• Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2 - Nature
• Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor - Nature