Why is "G9a" trending?

Search Interest Perspective

• G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease - Nature
• Novel G9a-Inhibitor Shows Promise - Docwire News
• De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity - Nature
• Histone Methyltransferase G9a in Primary Sensory Neurons Promotes Inflammatory Pain and Transcription of Trpa1 and Trpv1 via Bivalent Histone Modifications - Journal of Neuroscience
• New Alzheimer's Treatment Strategy Reverses Cognitive Decline in Mice - ScienceAlert
• G9a-mediated H3K9me2 orchestrates intestinal epithelial regeneration through epigenetic silencing of cell cycle-related genes - Nature
• G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials - Wiley Online Library
• G9a selectively represses a class of late-replicating genes at the nuclear periphery - PNAS
• Deficiency of G9a boosts muscle regeneration through IL13/Musclin-mediated crosstalk between macrophage and myofiber - Nature
• Decitabine suppresses triple-negative breast cancer by disrupting DNMT1 liquid-liquid phase separation and synergizes with G9a inhibition - Nature
• The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice | Scientific Reports - Nature
• Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice - Nature
• G9a deficiency activates TMEM27 to promote ferroptosis and enhances radiosensitivity in head and neck squamous cell carcinoma - Nature
• PRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition - Nature
• A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression - Nature
• Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis - Nature
• Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology - Nature
• The histone H3K9 methyltransferase G9a regulates tendon formation during development - Nature
• G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma - Nature
• The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors - Nature
• SPOP mutation induces DNA methylation via stabilizing GLP/G9a - Nature
• Identification of an Epi-metabolic dependency on EHMT2 /G9a in T-cell acute lymphoblastic leukemia - Nature
• ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers - Nature
• G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation - Nature
• Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis - Nature
• Epigenetic regulation of starvation-induced autophagy in Drosophila by histone methyltransferase G9a - Nature
• G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression - Nature
• SUMOylation of G9a regulates its function as an activator of myoblast proliferation - Nature
• PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells - Nature
• Functional Role of G9a Histone Methyltransferase in Cancer - Frontiers
• G9a-mediated H3K9me2 protects centromere integrity - EurekAlert!
• Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies - Nature
• Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome - Nature
• G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin - Nature
• G9a-dependent histone methylation can be induced in G1 phase of cell cycle - Nature
• G9a Histone Methyltransferase Activity in Retinal Progenitors Is Essential for Proper Differentiation and Survival of Mouse Retinal Cells - Journal of Neuroscience
• Histone methyltransferase G9a is a key regulator of the starvation-induced behaviors in Drosophila melanogaster - Nature
• Histone methyltransferase G9a contributes to H3K27 methylation in vivo - Nature
• G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway - Nature
• G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons - Nature
• G9a inhibits MEF2C activity to control sarcomere assembly - Nature
• MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a - Nature
• Cyclin D1 integrates G9a-mediated histone methylation - Nature
• A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells - Nature
• G9a coordinates with the RPA complex to promote DNA damage repair and cell survival - PNAS
• Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice - Nature
• Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a - Nature
• TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a - Science | AAAS
• G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis - PNAS
• G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner - Nature
• Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage | Scientific Reports - Nature
• G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes - PNAS
• HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype - Nature
• Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer - Nature
• KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels - Nature
• G9a/GLP Histone Lysine Dimethyltransferase Complex Activity in the Hippocampus and the Entorhinal Cortex Is Required for Gene Activation and Silencing during Memory Consolidation - Journal of Neuroscience
• Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours - Nature
• G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease by Bellver-Sanchis et al. - UB - Universitat de Barcelona
• Author Correction: G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin - Nature
• The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin - Science | AAAS
• De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes - Nature
• Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells - Nature
• The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells | Blood Cancer Journal - Nature
• G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis - Nature
• Protein lysine methyltransferase G9a acts on non-histone targets - Nature
• BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells - Nature
• Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294 - Nature
• H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression - Nature
• Morphine Epigenomically Regulates Behavior through Alterations in Histone H3 Lysine 9 Dimethylation in the Nucleus Accumbens - Journal of Neuroscience
• Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells - Nature
• PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing - Nature
• Epigenetic Regulation to Treat Lung Cancer May Instead Support Progression - Inside Precision Medicine
• TALE-directed local modulation of H3K9 methylation shapes exon recognition - Nature
• MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites | Scientific Reports - Nature
• The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules - Nature
• A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing - Nature
• Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome - Nature
• Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines - Nature
• 5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation - Nature
• The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes - Nature
• Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1α expression via cooperation between DNMT1 and G9a - Wiley Online Library
• Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery - Frontiers
• 2019 Chevrolet Volt in Green Mist Metallic G9A - GM Authority
• UMIDIGI G9 Series Launches in Bangladesh: UMIDIGI's Budget Killer Makes a Splash - Gizchina.com
• Umidigi G9A Price in Bangladesh 2026, Specs & Review - MobileDokan