Why is "G-quadruplex" trending?

Search Interest Perspective

• Precise discrimination of G-quadruplex conformation by chiral nanoassembly with photo-reversibility - Nature
• Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA - Wiley Online Library
• Researchers uncover the hidden structure of an RNA–DNA hybrid g-quadruplex - EurekAlert!
• Inhibition of DDX5-Mediated G-Quadruplex Unwinding in the β-Catenin 5′-UTR by Magnesium Isoglycyrrhizinate Alleviates Chemotherapy-Induced Intestinal Injury - Science Partner Journals
• Overlooked DNA structures help organize the genome - Phys.org
• Rare genetic diseases associated with G-quadruplex-induced replication stress - Nature
• Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures - Wiley Online Library
• In vivo dynamics of G-quadruplex DNA structures during liver regeneration in mice - Nature
• Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras - Nature
• G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation - Wiley & Sons
• TOP1α-mediated stabilization of CYP82C4 G-quadruplex DNA represses lateral root primordium initiation in Arabidopsis - Nature
• Telomeric G-quadruplex intermediates unveiled by complex Markov network analysis - Nature
• ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes - Nature
• Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation - Nature
• BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress | Communications Biology - Nature
• Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer | Communications Biology - Nature
• Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes - Nature
• Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties - Nature
• G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments - Nature
• Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics - Nature
• Structural switches: intracellular G-quadruplexes modulate DNA repair and genome maintenance in Deinococcus radiodurans - ASM Journals
• Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein - Nature
• Platinum-based phosphorescent lifetime probes for the visualisation of G-quadrup - Imperial College London
• RNA G‐Quadruplex RIBOTAC‐Mediated Targeted Degradation of lncRNA TERRA - Wiley & Sons
• Coexistence of G-Quadruplex and i-Motif Within a DNA Duplex is Tolerated by a PCBP2-Assisted Replisome - Wiley Online Library
• Degradation of G-Quadruplex-Binding Proteins by G4L-PROTAC via Quaternary Complex Formation - Wiley Online Library
• Postdoc Portrait: Paras Gaur Studies DNA Repair and G-Quadruplexes - the-scientist.com
• G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation - Science | AAAS
• Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands - Nature
• Folding of DNA into a quadruple helix might regulate cellular organisation and gene expression - Imperial College London
• Structural basis for nucleolin recognition of MYC promoter G-quadruplex - Science | AAAS
• G-quadruplex DNA structures in human stem cells and differentiation - Nature
• Structure of an RNA G-quadruplex from the West Nile virus genome - Nature
• Crosstalk between G-quadruplex and ROS - Nature
• Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch - Nature
• Stress promotes RNA G-quadruplex folding in human cells - Nature
• RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing - EurekAlert!
• Machine learning-based prediction of DNA G-quadruplex folding topology with G4ShapePredictor - Nature
• Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation - Nature
• G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD - Nature
• Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge - Nature
• Single-cell mapping of DNA G-quadruplex structures in human cancer cells - Nature
• Identifying G-quadruplex-interacting proteins in cancer-related gene promoters - Nature
• Chemical profiling of DNA G-quadruplex-interacting proteins in live cells - Nature
• RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons - Science | AAAS
• RNA G-quadruplex structure contributes to cold adaptation in plants - Nature
• Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates - Nature
• Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome - Nature
• The effect of prolonged G-quadruplex stabilization on the functions of human cells - Nature
• Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription - pnas.org
• G-quadruplexes in MTOR and induction of autophagy - Nature
• Asymmetric distribution of G-quadruplex forming sequences in genomes of retroviruses - Nature
• Alternative splicing modulation by G-quadruplexes - Nature
• G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis - Nature
• Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution - Nature
• mGem: Noncanonical nucleic acid structures—powerful but neglected antiviral targets - ASM Journals
• DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory - Journal of Neuroscience
• Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy - Nature
• Structural basis for inactivation of PRC2 by G-quadruplex RNA - Science | AAAS
• Multistep mechanism of G-quadruplex resolution during DNA replication - Science | AAAS
• Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization - Nature
• Ion slippage through Li+-centered G-quadruplex - Science | AAAS
• Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex - Nature
• Involvement of G-quadruplex regions in mammalian replication origin activity - Nature
• Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes - Nature
• G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing - Nature
• Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Nature
• Single-molecule visualization of DNA G-quadruplex formation in live cells - Nature
• DNA:RNA hybrid G-quadruplex formation upstream of transcription start site - Nature
• Deep learning deciphers the related role of master regulators and G-quadruplexes in tissue specification - Nature
• G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease - Nature
• DNA G-quadruplex structures mold the DNA methylome - Nature
• Transcriptome-wide identification of transient RNA G-quadruplexes in human cells - Nature
• G-quadruplex structures mark human regulatory chromatin - Nature
• Unmodified RNA sequences form unusual stable G-quadruplexes with potential anti-RSV and anti-angiogenesis applications - Nature
• G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes - pnas.org
• Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs - Nature
• Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding - Nature
• Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36 - Nature
• Locking up G-Quadruplexes with Light-Triggered Staples Leads to Increased Topological, Thermodynamic, and Metabolic Stability - Wiley Online Library
• RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand - Nature
• RNA G-quadruplex structures control ribosomal protein production - Nature
• Unraveling the Regulatory G-Quadruplex Puzzle: Lessons From Genome and Transcriptome-Wide Studies - Frontiers
• Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array - Nature
• Machine learning model for sequence-driven DNA G-quadruplex formation - Nature
• G-quadruplexes rescuing protein folding - pnas.org
• Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation - Nature
• Exploration of the Structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its Transcriptional Regulation - Nature
• G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition - Nature
• DNA secondary structures: stability and function of G-quadruplex structures - Nature
• DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells - pnas.org
• Genome-wide discovery of G-quadruplexes in barley - Nature
• Functional and Structural Analyses of Diverse G-Quadruplex and Non-G-Quadruplex Structures Formed by Guanine-Rich Nucleic Acids: A Study on the Insulin Aptamer - Wiley Online Library
• Mechanical insights into ribosomal progression overcoming RNA G-quadruplex from periodical translation suppression in cells - Nature
• Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics - Nature
• Genome-wide discovery of G-quadruplex forming sequences and their functional relevance in plants - Nature
• Confined space facilitates G-quadruplex formation - Nature
• Identification and characterization of G-quadruplex formation within the EP0 promoter of pseudorabies virus - Nature
• G-quadruplex structures are stable and detectable in human genomic DNA - Nature
• Characterization of highly conserved G-quadruplex motifs as potential drug targets in Streptococcus pneumoniae - Nature