Why is "Folinic acid" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-07-20 10:18:32
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Folinic_acid entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-07-20 and was most recently seen on 2026-07-20.
Wikipedia Overview
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, and may be used to treat folate deficiency, anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein. Better known as 5-formyltetrahydrofolate in biochemistry, it is a natural form of folate, albeit with no clear function.
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Trending Topic Today
Search Interest Perspective
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Can Leucovorin (Folinic Acid) Treat Autism Features? - Springer Nature Link
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What you should know about vaccines, Tylenol and folinic acid in autism - CHOC - Children's Health Hub
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Is there a medication to treat autism? - Children's Hospital of Philadelphia
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Five things to know about folinic acid and autism - medicalxpress.com
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Leucovorin Prescriptions for Children with Autism Surged After Public Attention - UC San Diego Today
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Can the prescription drug leucovorin treat autism? History says, probably not - NPR
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Largest leucovorin-autism trial retracted - The Transmitter
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Triquetra Health Launches FolinicActive Kids -- Only USDA Organic Folinic Acid Formula with Multi-Pathway Folate Flexibility, Designed for Children Ages 1-18 - Yahoo Finance
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Triquetra Health expands supplement portfolio with amino acid and active folate launches - Nutraceutical Business Review
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What you should know before buying folate and folinic acid supplements - The Washington Post
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Clinical Research Evaluates Folinic Acid for Brain Development Support in Children – FolinicActive Kids Delivers Ingredient at Studied Dose - USA Today
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FDA approves leucovorin as first drug for rare genetic disorder, after touting it as autism treatment - CNBC
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Trump and RFK Jr touted leucovorin as a treatment for autism. The FDA quietly walked it back - The Guardian
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Folinic Acid May Improve Verbal Skills in Children With ASD - Psychiatry Online
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FDA Initiates Approval of Leucovorin Calcium for Cerebral Folate Deficiency With Autistic Features - Vera Health
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Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial | Molecular Psychiatry - Nature
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As parents clamor for a treatment touted for autism, doctors hesitate to prescribe it - NPR
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Triquetra Health Launches FolinicActive™ Adult Liquid--First Multi-Pathway Active Folate with Complete Tri-Cofactor System - Yahoo Finance
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Triquetra Health Launches FolinicActive™--First Multi-Pathway Active Folate with Complete Tri-Cofactor System - Yahoo Finance
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Leucovorin for autism? Many scientists — and parents — are skeptical : Shots - Health News - NPR
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Leucovorin has a place in autism treatment, researcher says, but he tamps down parents’ expectations - STAT
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Q&A: What is leucovorin, now being hailed as an autism treatment? - UVA Today
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Autism Trial Supporting FDA-Touted Drug Is Retracted - MedPage Today
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Leucovorin - Autism Science Foundation
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Trump team backs an unproven drug for autism — but does it work? - Nature
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FDA declines leucovorin for autism treatment, approves for rare condition - NonStop Local KHQ
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Is leucovorin an effective treatment for autism? Here's what research shows - NBC News
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Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas - Nature
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Phase I trial of Bermekimab with nanoliposomal irinotecan and 5-fluorouracil/folinic acid in advanced pancreatic ductal adenocarcinoma - Nature
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What Is Leucovorin, the Medicine Being Approved for Autism Treatment? - The New York Times
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FDA’s leucovorin approval could be a boon for supplement makers - STAT
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Late diagnosis of cerebral folate deficiency: Fewer seizures with folinic acid in adult siblings - Neurology® Journals
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5-fluorouracil and high dose folinic acid in hormone-refractory metastatic prostate cancer: a phase II study - National Institutes of Health (NIH) | (.gov)
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Treatment of patients with carcinomas in advanced stages with 5-fluorouracil, folinic acid and pyridoxine in tandem - Nature
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Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma - Nature
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Small study finds folinic acid improves communication & eases symptoms of autism - Autism Speaks
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Nanoliposomal irinotecan with fluorouracil and folinic acid, FOLFIRINOX, and S-1 as second-line treatment for unresectable pancreatic cancer after gemcitabine/nab-paclitaxel - Nature
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Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment - Nature
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F.D.A.’s Approval of a Drug for Autism Upends Review Process - The New York Times
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ASF Statement on White House Announcement on Autism - Autism Science Foundation
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Does the Unproven Autism Drug Backed by Trump Really Work? - Scientific American
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RFK Jr. Announces FDA Will Approve Leucovorin, a New Treatment for Autism. What Is It? - People.com
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What is leucovorin, the drug the FDA approved to treat autism? - The Guardian
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Autism, Acetaminophine, Folinic Acid. Research Continues - What Parents Will Want to Know - RINewsToday
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A multicenter retrospective observational NAPOLEON2 study of nanoliposomal irinotecan with fluorouracil and folinic acid in patients with unresectable pancreatic cancer - Nature
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What is leucovorin, the drug Trump claims can help treat autism? - ABC News & Headlines – Australian Broadcasting Corporation
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What to Know About Leucovorin, an Old Drug Rebranded as an Autism Treatment - Time Magazine
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Why is leucovorin being considered as an autism treatment? - Reuters
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Dr Raghav on a Phase 2 Study of ABBV-400 Plus Fluorouracil, Folinic Acid, and Bevacizumab in Pretreated Metastatic CRC - OncLive
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Will Dr Oz Benefit From Trump’s FDA Approving Leucovorin? What To Know - newsweek.com
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Folinic acid therapy in cerebral folate deficiency: marked improvement in an adult patient - Springer Nature Link
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FDA to approve drug to treat autism symptoms - Politico
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Folinic Acid Shows Promise as Parkinson’s Treatment in Fruit Fly Study - parkinsonsnewstoday.com
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Folinic acid shows potential for Parkinson’s disease in fruit flies - The Pharmaceutical Journal
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FDA approves drug that Trump due to suggest as autism treatment - Reuters
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Spontaneous Aortic Haematoma in a Patient Receiving Adjuvant Folinic Acid, 5-Fluorouracil, Irinotecan, and Oxaliplatin Chemotherapy Following Resection of a Pancreatic Adenocarcinoma - Cureus
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Before Trump touted the drug leucovorin for autism, these families had already tried it - NBC News
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Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis - Wiley Online Library
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User Clip: Food and Drug Commissioner Dr. Martin Makary explains the association between the use of prenatal acetaminophen ( Tylenol ) and neurodevelopmental disorders of ADHD and Autism Spectrum Disorder, and how the drug Leucovorin, also known - C-SPAN
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Does leucovorin treat autism? What to know about FDA approval of folinic acid treatment - Delawareonline.com
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AR Children’s Research Shows Folinic Acid Could Help Autistic Children - KARK
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Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder - Frontiers
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Fact Check: Dr. Oz Will NOT Profit From iHerb When Trump FDA Recommends Leucovorin For Treatment Of Autism - Oz Sold Shares, Resigned Paid Post - Yahoo
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Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study - The Lancet
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Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials - Nature
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What is Leucovorin? Trump’s FDA Approves Drug to Treat Autism Symptoms - newsweek.com
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What is leucovorin, and can it cure autism? - Medical Republic
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Explainer: Why is leucovorin being considered as a treatment for autism? - The Straits Times
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Folinic acid–responsive seizures are identical to pyridoxine‐dependent epilepsy - Wiley Online Library
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Fluorouracil/folinic acid/oxaliplatin - Springer Nature Link
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Impact of the oxaliplatin-5 fluorouracil-folinic acid combination on respective intracellular determinants of drug activity - Nature
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FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised phase III trial from the Hellenic Oncology Research G - Nature
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The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis - Wiley Online Library
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Randomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC) - Nature
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Again, 'autism reversal' is not a thing: Why leucovorin and folinic acid are not 'breakthrough' treatments - Liam O'Dell
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A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients | British Journal of Cancer - Nature
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Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases - Nature
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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer - Nature
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Folinic acid may help autistic kids improve communication skills | Health - Hindustan Times
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.