Why is "Exonuclease" trending?

Search Interest Perspective

• Structural basis of Ku-mediated activation of WRN exonuclease activity - Nature
• A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance - ASM Journals
• Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury - Science | AAAS
• A single gene underlies begomovirus resistance in eggplant - EurekAlert!
• Exonucleases Market Size, Share, Trend | Growth Report [2034] - Fortune Business Insights
• 18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′-End Modification During TOR Inhibition. - Wiley Online Library
• Mechanistic insights into single-stranded DNA degradation by lysosomal exonucleases PLD3 and PLD4 from structural snapshots - Nature
• The yeast checkpoint kinase Mec1p functions in transcription termination by facilitating recruitment of Pcf11p and regulating the torpedo exonuclease Rat1p - Nature
• Exonuclease-enhanced prime editors - Nature
• Single 3′-exonuclease-based multifragment DNA assembly method (SENAX) - Nature
• Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases - Nature
• DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity - Nature
• Bacteriophage λ exonuclease and a 5′-phosphorylated DNA guide allow PAM-independent targeting of double-stranded nucleic acids - Nature
• The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication - Nature
• Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms - Nature
• New insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase - Nature
• Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture - Nature
• Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing - Nature
• REXO5 promotes genomic integrity through regulating R-loop using its exonuclease activity - Nature
• An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping - Nature
• Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes - Science | AAAS
• A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links - Nature
• A signal transmission strategy driven by gap-regulated exonuclease hydrolysis for hierarchical molecular networks - Nature
• Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex - Nature
• Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance - Nature
• Single-exonuclease nanocircuits reveal the RNA degradation dynamics of PNPase and demonstrate potential for RNA sequencing - Nature
• MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair - Nature
• ExoMeg1: a new exonuclease from metagenomic library - Scientific Reports - Nature
• SbcB facilitates natural transformation in Vibrio cholerae in an exonuclease-independent manner - ASM Journals
• xrRNAs adopt a long-lived conformation that prevents exonuclease activity - Nature
• Structural and functional investigation of DinG containing a 3′–5′ exonuclease domain - ASM Journals
• Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria - Nature
• A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease - Nature
• Dynamic coordination of two-metal-ions orchestrates λ-exonuclease catalysis - Nature
• Crystal structures of λ exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity - PNAS
• Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies - Nature
• The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins - Nature
• Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA - Nature
• Structure of Escherichia coli exonuclease I suggests how processivity is achieved - Nature
• Chilling stress and loss of an exonuclease lead to biparental inheritance of plastids - Nature
• The 3′–5′ exonucleases - Nature
• Cas9 has no exonuclease activity resulting in staggered cleavage with overhangs and predictable di- and tri-nucleotide CRISPR insertions without template donor - Nature
• Polynucleotide phosphorylase functions both as a 3′ → 5′ exonuclease and a poly(A) polymerase in Escherichia coli - PNAS
• Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication - Science | AAAS
• A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20 - Nature
• Deficiency of the lysosomal exonuclease PLD3 impacts the degradative route - Wiley & Sons
• Relationship of DNA degradation by Saccharomyces cerevisiae Exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection - PNAS
• APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling - Nature
• Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex - PNAS
• BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases - Nature
• ion suggests how its characteristic motifs are involved in exonuclease activity - PNAS
• Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria - Nature
• Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo - Nature
• Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path - Nature
• The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair - Nature
• Calcium Influx Guards Replication Forks against Exonuclease 1 - ScienceDirect.com
• A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway - Nature
• The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 - Nature
• Bulge, Bubble, and Y: How an RNA Exonuclease Repairs DNA, in Detail - PLOS
• Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation - PNAS
• ε replicase promotes polymerization and reduces exonuclease activity - Nature
• Unlocking the power of DNA exonucleases and endonucleases in immunity - EurekAlert!
• The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks - Nature
• Noncatalytic aspartate at the exonuclease domain of proofreading DNA polymerases regulates both degradative and synthetic activities - PNAS
• Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing - Nature
• ChIP-Exonuclease Kit - Inside Precision Medicine
• Sequence-Dependent Pausing of Single Lambda Exonuclease Molecules - Science | AAAS
• Molecular snapshots of APE1 proofreading mismatches and removing DNA damage - Nature
• An Exonuclease III‐Powered, On‐Particle Stochastic DNA Walker - Wiley Online Library
• Shedding light on the mechanism of yeast DNA repair - EurekAlert!
• Single-molecule analysis reveals three phases of DNA degradation by an exonuclease - Nature
• The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II - Nature
• Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations - Nature
• Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes - Nature
• Human 5′ → 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites - Nature
• Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions - PNAS
• Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I - PNAS
• WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing - Nature
• Discovering TREX1 inhibitors with the Transcreener dAMP Exonuclease Assay - News-Medical
• Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε - Nature
• The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi - Nature
• Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus - Nature
• Substrate selectivity by the exonuclease Rrp6p - PNAS
• Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice - Nature
• Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease - Science | AAAS
• C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy - Nature
• p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis - Nature
• Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus - Nature
• 5′ → 3′ Exonuclease-Based Real-Time PCR Assays for Detecting the t(14;18)(q32;21): A Survey of 162 Malignant Lymphomas and Reactive Specimens - Nature
• Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair - PNAS
• Blinded histopathological characterisation of POLE exonuclease domain mutant endometrial cancers: sheep in wolf's clothing - Wiley Online Library
• Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins - PNAS
• The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease - Nature
• Samantha Grimes | Chemical Biology of Infectious Disease Training Program - Vanderbilt University Medical Center |
• Decay of a Model mRNA in Bacillus subtilis by a Combination of RNase J1 5′ Exonuclease and RNase Y Endonuclease Activities - ASM Journals
• Structural Basis for the Bidirectional Activity of Bacillus nanoRNase NrnA - Nature
• Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3′-to-5′ Direction and Is Dependent on the 3′-to-5′ Exonuclease Active Site - ASM Journals
• Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins - Nature
• Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA - Nature
• Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs - PNAS