Why is "Epithelial sodium channel" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-13 18:24:13
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Epithelial_sodium_channel entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-13 and was most recently seen on 2026-04-13.
Wikipedia Overview
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na+). It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D. The ENaC is involved primarily in the reabsorption of sodium ions at the collecting ducts of the kidney's nephrons. In addition to being implicated in diseases where fluid balance across epithelial membranes is perturbed, including pulmonary edema, cystic fibrosis, COPD and COVID-19, proteolyzed forms of ENaC function as the human salt taste receptor.
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Trending Topic Today
Search Interest Perspective
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Transgenically expressed human delta epithelial sodium channel facilitated fluid absorption in mouse fetal lung explants - American Physiological Society Journal
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Sorting nexins associated with recycling complexes regulate epithelial sodium channel trafficking - American Physiological Society Journal
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Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation - science.org
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The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing - nature.com
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Epithelial sodium channel regulated by aldosterone-induced protein sgk - PNAS
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OHSU discovers molecular channel that regulates blood pressure - news.ohsu.edu
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Epithelial Sodium Channel and Salt-Sensitive Hypertension - American Heart Association Journals
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Pulmonary Epithelial Sodium-Channel Dysfunction and Excess Airway Liquid in Pseudohypoaldosteronism - The New England Journal of Medicine
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Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019 - onlinelibrary.wiley.com
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The serine protease plasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in Dahl salt-sensitive rats - nature.com
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WNK1 activates SGK1 to regulate the epithelial sodium channel - PNAS
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The Epithelial Sodium Channel and the Processes of Wound Healing - Chifflet - 2016 - BioMed Research International - onlinelibrary.wiley.com
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The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na - PNAS
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Role of the epithelial sodium channel in salt-sensitive hypertension - nature.com
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Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel - nature.com
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An oxygen-sensitive mechanism in regulation of epithelial sodium channel - PNAS
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Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity - nature.com
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Hormonal Regulation and Genomic Organization of the Human Amiloride-Sensitive Epithelial Sodium Channel α Subunit Gene - nature.com
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Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel - nature.com
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Postprandial Effects on ENaC-Mediated Sodium Absorption - nature.com
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Association of hypertension with T594M mutation in β subunit of epithelial sodium channels in black people resident in London - thelancet.com
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.