Why is "ERAP1" trending?

Search Interest Perspective

• The impact of ERAP1 inhibition on metabolite homeostasis of melanoma cells | Scientific Reports - Nature
• Greywolf reports early responses with oral ERAP1 inhibitor in solid tumours - European Biotechnology Magazine
• Genetic Polymorphism of ERAP-1 in Ankylosing Spondylitis - European Society of Medicine
• How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins - Frontiers
• ERAP1 biology and assessment in Ankylosing Spondylitis - PNAS
• Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism - Nature
• Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications - Frontiers
• ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP - Nature
• To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2 - Frontiers
• ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis | Scientific Reports - Nature
• ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing - Nature
• An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes - Nature
• Epistatic Interaction of ERAP1 and HLA-B*51 in Iranian Patients with Behçet’s Disease - Nature
• p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1 - Nature
• The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues - Nature
• Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 - Nature
• Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1 - Nature
• T cell responses by targeting the aminopeptidase ERAP1 - Nature
• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 - Nature
• An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides - Nature
• Shedding Light on the Role of ERAP1 in Axial Spondyloarthritis - Cureus
• Greywolf Therapeutics Initiates Dosing of First-in-Class Autoimmunity Treatment - The Clinical Trial Vanguard
• Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility - Nature
• A large meta-analysis identifies genes associated with anterior uveitis - Nature
• EMITT-1 Study: GRWD5769 Plus Cemiplimab in Anti–PD-1–Resistant Solid Tumors and MSS Colorectal Cancer - Oncodaily
• Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1 - Nature
• Greywolf Therapeutics begins dosing of the first treatment to target the antigenic source of autoimmunity - BioSpace
• Gene Interaction Increases Patients’ Risk of Frontal Fibrosing Alopecia - HCPLive
• The final cut: how ERAP1 trims MHC ligands to size - Nature
• Blood pressure regulation by a stress-sensitive gatekeeper - healthcare-in-europe.com
• Gene test for ankylosing spondylitis steps closer - Medical News Today
• Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis - Wiley Online Library
• Genomics inks partnership deal with Greywolf to assess gene datasets - Fierce Biotech
• Complex Genetics of Frontal Fibrosing Alopecia Uncovered - Inside Precision Medicine
• A new cancer pill may help the immune system see tumors that once stayed hidden - Earth.com
• New insight into risk of Ankylosing Spondylitis - southampton.ac.uk
• Scientists discover new gene-to-gene interaction increasing risk of alopecia - King's College London
• Grey Wolf Therapeutics Announces Dosing of First Patient in Phase 1/2 Clinical Study of GRWD5769 in Patients with Advanced Solid Tumours - aap.com.au
• Ankylosing Spondylitis: Genetic Factors and Quality of Life - PlexusDx
• Hope for spine-fusing arthritis - BBC