Why is "EGLN1" trending?

Search Interest Perspective

• EGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting | Experimental & Molecular Medicine - Nature
• EGLN1 inhibition reverses angiogenesis impairment in hyperglycemia by activating autophagy - Nature
• EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda - PNAS
• Scientists Discovered Humans Are Still Actively Evolving - Popular Mechanics
• Genetic Links Uncovered Between Iron Supplement Drug Targets and IBD - Docwire News
• Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude - Wiley Online Library
• PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma - The New England Journal of Medicine
• Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3 - Nature
• Proline hydroxylation linked to Akt activation - Science | AAAS
• Single-Cell and Spatial Transcriptomics Identified Fatty Acid–Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension - American Heart Association Journals
• Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor - PNAS
• EGLN1 mutations in Cis can induce congenital erythrocytosis with thromboses by increasing protein instability - Wiley Online Library
• Somatic HIF2A Gain-of-Function Mutations in Paraganglioma with Polycythemia - The New England Journal of Medicine
• Admixture facilitates genetic adaptations to high altitude in Tibet - Nature
• MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders - Nature
• Clinical utility gene card for: familial polycythaemia vera | European Journal of Human Genetics - Nature
• Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans - Nature
• Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing - Nature
• Translocation renal cell carcinoma says no to the Warburg effect - Nature
• Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2 - Nature
• Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production - PNAS
• Ancient DNA reveals selection acting on genes associated with hypoxia response in pre-Columbian Peruvian Highlanders in the last 8500 years - Nature
• Genomic insights into adaptation to high-altitude environments - Nature
• The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling - Springer Nature Link
• Welcome Dr. Tsewang Tashi to the Faculty - U of U School of Medicine - School of Medicine | University of Utah
• New research shows genetic adaptations help Tibetans thrive at high elevations - University of Chicago News
• These Athletes Weren't Doping. Their Genes Made It Look Like They Did. - MedPage Today
• Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways - Wiley Online Library
• The role of PHD2 mutations in the pathogenesis of erythrocytosis - Dove Medical Press
• Genotype–phenotype correlation of hereditary erythrocytosis mutations, a single center experience - Wiley Online Library
• Clinical utility gene card for: familial erythrocytosis - Nature
• 8000-year-old gene helps Tibetans thrive at high altitudes: study finds - Central Tibetan Administration