Why is "Dynein" trending?

Search Interest Perspective

• Cracking the (zip)code of dynein-dependent RNA localization - Nature
• Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis - PNAS
• Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1 - Frontiers
• Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation - Nature
• CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization - Rockefeller University Press
• HIV-1 binds dynein directly to hijack microtubule transport machinery - Science | AAAS
• Dynein-Dependent Endo-Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology - Wiley
• A nucleotide code governs Lis1’s ability to relieve dynein autoinhibition - Nature
• Dynein and dynactin move long-range but are delivered separately to the axon tip - Rockefeller University Press
• Roles of microtubules and LIS1 in dynein transport machinery assembly - Nature
• KIF5B and Dynein-Dependent Golgi Organization: Role in Adhesion-Dependent Microtubule Acetylation - Wiley Online Library
• Molecular basis for the activation of outer dynein arms in cilia - Nature
• Cryo-EM captures early intermediate steps in dynein activation by LIS1 - Nature
• Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking - Nature
• Multiple steps of dynein activation by Lis1 visualized by cryo-EM - Nature
• Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein - Nature
• Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms - Nature
• Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein - Nature
• The mechanochemical cycle of reactive full-length human dynein 1 - Nature
• Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport - Nature
• Molecular mechanism of dynein-dynactin complex assembly by LIS1 - Science | AAAS
• MINFLUX reveals dynein stepping in live neurons - PNAS
• Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism - Nature
• KIF1C activates and extends dynein movement through the FHF cargo adapter - Nature
• The cytoplasmic dynein transport machinery and its many cargoes - Nature
• Dynein–Dynactin–NuMA Complex: Activation and Regulation Explained - Bioengineer.org
• Molecular mechanism of cytoplasmic dynein tension sensing - Nature
• Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism - Nature
• Structure of dynein–dynactin on microtubules shows tandem adaptor binding - Nature
• Functions and mechanics of dynein motor proteins - Nature
• Nde1 promotes Lis1-mediated activation of dynein - Nature
• Vesicles driven by dynein and kinesin exhibit directional reversals without regulators - Nature
• Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport - Wiley Online Library
• TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport - Nature
• Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen - Rockefeller University Press
• A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner - Nature
• Directionality of dynein is controlled by the angle and length of its stalk - Nature
• BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M - Nature
• Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein - Nature
• A subpellicular microtubule dynein transport machinery regulates ookinete morphogenesis for mosquito transmission of Plasmodium yoelii - Nature
• Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules - Nature
• Versatile properties of dynein molecules underlying regulation in flagellar oscillation - Nature
• Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors - Nature
• In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport - PNAS
• Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport - Nature
• Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity - Nature
• The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein - Nature
• Cytoplasmic dynein transports cargos via load-sharing between the heads - Nature
• Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway - Rockefeller University Press
• Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia - Nature
• Structure of the dynein-2 complex and its assembly with intraflagellar transport trains - Nature
• KIF1C facilitates retrograde transport of lysosomes through Hook3 and dynein - Nature
• Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility - Science | AAAS
• A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light - Science | AAAS
• Sequential accumulation of dynein and its regulatory proteins at the spindle region in the Caenorhabditis elegans embryo - Nature
• Tensile Stress on Microtubules Facilitates Dynein-Driven Cargo Transport | Nano Letters - ACS Publications
• Lis1 slows force-induced detachment of cytoplasmic dynein from microtubules - Nature
• Tension on the linker gates the ATP-dependent release of dynein from microtubules - Nature
• A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity - Nature
• Dynein harnesses active fluctuations of microtubules for faster movement - Nature
• Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by MD simulation - Nature
• Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution - Nature
• Crystal Structure of the Dynein Motor Domain - Science | AAAS
• Structural mechanism of the dynein power stroke - Nature
• Microscopic chariots deliver molecules within our cells - Scripps Research
• Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ - Nature
• Motor Protein Dynamics Guide Brain Disease Drug Targeting - Genetic Engineering and Biotechnology News
• Fluctuation in the cytoplasm enhances directed transport - 国立遺伝学研究所
• Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation - Journal of Neuroscience
• Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin - Rockefeller University Press
• Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin - Nature
• RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning - Nature
• Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein - Nature
• Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands - Nature
• Cytoplasmic dynein binding, run length, and velocity are guided by long-range electrostatic interactions - Nature
• Lis1 activates dynein motility by modulating its pairing with dynactin - Nature
• Neuron movements caused by push, pull of motor proteins, study finds - The Pennsylvania State University
• Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders - Frontiers
• Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity - Nature
• Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans- Golgi network during virus entry - ASM Journals
• The 2.8 Å crystal structure of the dynein motor domain - Nature
• Combinations of deletion and missense variations of the dynein-2 DYNC2LI1 subunit found in skeletal ciliopathies cause ciliary defects - Nature
• MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment - Nature
• Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division - Science | AAAS
• The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia - Nature
• Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance - PNAS
• Three-dimensional structure of cytoplasmic dynein bound to microtubules - PNAS
• Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide - Nature
• Oocyte Patterning: Dynein and Kinesin, Inc. - ScienceDirect.com
• Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin - Rockefeller University Press
• JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis - Nature
• CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization | Journal of Cell Biology - Rockefeller University Press
• Functional and structural significance of the inner‐arm‐dynein subspecies d in ciliary motility - Wiley Online Library
• Dynactin functions as both a dynamic tether and brake during dynein-driven motility - Nature
• In vitro reconstitution of a highly processive recombinant human dynein complex - Springer Nature Link
• Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers - Nature
• Control of cytoplasmic dynein force production and processivity by its C-terminal domain - Nature
• The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein - Rockefeller University Press
• A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport - Rockefeller University Press
• Dynein‐Powered Cell Locomotion Guides Metastasis of Breast Cancer - Wiley