Why is "Dynactin" trending?

Search Interest Perspective

• Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation - Nature
• Molecular mechanism of dynein-dynactin complex assembly by LIS1 - Science | AAAS
• Dynein and dynactin move long-range but are delivered separately to the axon tip - Rockefeller University Press
• Dynactin 1 negatively regulates HIV-1 infection by sequestering the host cofactor CLIP170 - PNAS
• Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport - Journal of Neuroscience
• Structure of dynein–dynactin on microtubules shows tandem adaptor binding - Nature
• Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin - Rockefeller University Press
• The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex - Science | AAAS
• A nucleotide code governs Lis1’s ability to relieve dynein autoinhibition - Nature
• Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3 - Rockefeller University Press
• A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity - Nature
• Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin - Rockefeller University Press
• Cryo-EM shows how dynactin recruits two dyneins for faster movement - Nature
• Dynactin functions as both a dynamic tether and brake during dynein-driven motility - Nature
• Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility - Nature
• Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin - Nature
• Lis1 activates dynein motility by modulating its pairing with dynactin - Nature
• The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway - Nature
• Integrin-Linked Kinase links Dynactin-1/Dynactin-2 with cortical Integrin receptors to orient the mitotic spindle relative to the substratum - Nature
• RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin - Nature
• Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking - Nature
• Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport - Nature
• The retromer component SNX6 interacts with dynactin p150 - Nature
• Microscopic chariots deliver molecules within our cells - Scripps Research
• On and off controls within dynein–dynactin on native cargoes - PNAS
• Arl3 and LC8 regulate dissociation of dynactin from dynein - Nature
• Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein - Nature
• Processive bidirectional motion of dynein–dynactin complexes in vitro - Nature
• Investigating Mechanisms Behind Early HIV-1 Infection - Northwestern University
• Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein | Experimental & Molecular Medicine - Nature
• Mutant dynactin in motor neuron disease - Nature
• Dynactin increases the processivity of the cytoplasmic dynein motor - Nature
• Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin - PNAS
• In vitro reconstitution of a highly processive recombinant human dynein complex - Springer Nature Link
• The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly - Nature
• Single-molecule assays reveal that RNA localization signals regulate dynein–dynactin copy number on individual transcript cargoes - Nature
• Sequential accumulation of dynein and its regulatory proteins at the spindle region in the Caenorhabditis elegans embryo - Nature
• TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport - Nature
• Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex - PNAS
• Interaction of tau protein with the dynactin complex - Springer Nature Link
• Backseat drivers: Regulation of dynein motility - Nature
• Nde1 promotes Lis1-mediated activation of dynein - Nature
• Scientists Reveal Structural Secrets of Nature’s Little Locomotive - Neuroscience News
• Reconstitution of the human cytoplasmic dynein complex - PNAS
• CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation - PNAS
• Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif - Nature
• Interaction of Huntingtin-Associated Protein with Dynactin P150Glued - Journal of Neuroscience
• Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway - Rockefeller University Press
• Scientists discover how mutations in a language gene produce speech deficits - news.mit.edu
• Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands - Nature
• What looks alike comes together: the origin of actine's branching networks… - polytechnique.edu
• Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors - Nature
• Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement - Nature
• Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex - Nature
• SMA Understanding May Benefit from 3D Imaging of Protein Complex - SMA News Today
• Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae - Nature
• Vesicles driven by dynein and kinesin exhibit directional reversals without regulators - Nature
• CLIP-170 is essential for MTOC repositioning during T cell activation by regulating dynein localisation on the cell surface - Nature
• KIF1C activates and extends dynein movement through the FHF cargo adapter - Nature
• A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner - Nature
• Abundant motor proteins disrupt cries in FOXP2 mice - The Transmitter
• Multiple steps of dynein activation by Lis1 visualized by cryo-EM - Nature
• Discovery of agile molecular motors could aid in treating motor neuron diseases - EurekAlert!
• JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis - Nature
• A dynein loading zone for retrograde endosome motility at microtubule plus‐ends - Springer Nature Link
• Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions - Nature
• Assembly and Activity of the WASH Molecular Machine: Distinctive Features at the Crossroads of the Actin and Microtubule Cytoskeletons - Frontiers