Why is "Dendritic spine" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-24 04:17:31
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Dendritic_spine entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-24 and was most recently seen on 2026-06-24.
Wikipedia Overview
A dendritic spine is a small membrane protrusion from a neuron's dendrite that typically receives input from a single axon at the synapse. Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body. Most spines have a bulbous head, and a thin neck that connects the head of the spine to the shaft of the dendrite. The dendrites of a single neuron can contain hundreds to thousands of spines. In addition to spines providing an anatomical substrate for memory storage and synaptic transmission, they may also serve to increase the number of possible contacts between neurons. It has also been suggested that changes in the activity of neurons have a positive effect on spine morphology.
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Trending Topic Today
Search Interest Perspective
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Pathogenic human autoantibodies against NMDA receptor alter dendritic spine size | Scientific Reports - Nature
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Regulation of NMDA receptor interactions with the actin cytoskeleton in dendritic spine development - Frontiers
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Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model - Wiley & Sons
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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring - Nature
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Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling - Journal of Neuroscience
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Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats - Frontiers
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CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity - Journal of Neuroscience
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Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram - Nature
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Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool - Journal of Neuroscience
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Dendritic Spine Plasticity: Function and Mechanisms - Frontiers
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Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis - Nature
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Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling - Journal of Neuroscience
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REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex - Nature
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Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling in Dendritic Spine Shrinkage - Journal of Neuroscience
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Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory - Nature
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NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation - Journal of Neuroscience
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Altered dendritic spine function and integration in a mouse model of fragile X syndrome - Nature
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Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat - Nature
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Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons - Nature
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Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer’s disease - Nature
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Memory loss in aging and dementia: Dendritic spine head diameter predicts memory in old age - The University of Alabama at Birmingham
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Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling - Journal of Neuroscience
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Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons - Nature
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α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP - Nature
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LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice - Journal of Neuroscience
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P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice - Nature
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Dendritic spine dynamics in associative memory: A comprehensive review - Guo - 2023 - Wiley & Sons
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Neuronal plasticity affects correlation between the size of dendritic spine and its postsynaptic density - Nature
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Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex - Journal of Neuroscience
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Utilizing 2D-region-based CNNs for automatic dendritic spine detection in 3D live cell imaging - Nature
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CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity - Journal of Neuroscience
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Structural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions - Journal of Neuroscience
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EF1α-associated protein complexes affect dendritic spine plasticity by regulating microglial phagocytosis in Fmr1 knock-out mice - Nature
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Opposite effects of fear conditioning and extinction on dendritic spine remodelling - Nature
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Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia - Nature
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Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology - Nature
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Location-dependent synaptic plasticity rules by dendritic spine cooperativity - Nature
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Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a - Journal of Neuroscience
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RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviour - Nature
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Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation - Nature
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Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology | Scientific Reports - Nature
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Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome - Nature
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Dendritic spine and synapse pathology in chromatin modifier-associated autism spectrum disorders and intellectual disability - Frontiers
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Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins - Nature
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LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice - Journal of Neuroscience
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The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density - Nature
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Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex - Journal of Neuroscience
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Reversal of long-term dendritic spine alterations in Alzheimer disease models - PNAS
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Chronic Stress-Induced Alterations of Dendritic Spine Subtypes Predict Functional Decrements in an Hypothalamo–Pituitary–Adrenal-Inhibitory Prefrontal Circuit - Journal of Neuroscience
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Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats - Journal of Neuroscience
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Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo - PNAS
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Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex - Journal of Neuroscience
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Dendritic spine pathology in neuropsychiatric disorders - Nature
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Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses - Journal of Neuroscience
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Microtubules in Dendritic Spine Development - Journal of Neuroscience
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The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory - Frontiers
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Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis - Nature
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The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking - Journal of Neuroscience
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Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid - Science | AAAS
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Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance - Journal of Neuroscience
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PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function - Nature
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monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α - Nature
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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model - Journal of Neuroscience
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Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation - Journal of Neuroscience
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Tridimensional model of a dendritic spine with a spine apparatus in the mouse central nervous system. - Yale School of Medicine
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Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia - Nature
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Low-level Gestational Lead Exposure Alters Dendritic Spine Plasticity in the Hippocampus and Reduces Learning and Memory in Rats - Nature
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Layer 4 Pyramidal Neurons Exhibit Robust Dendritic Spine Plasticity In Vivo after Input Deprivation - Journal of Neuroscience
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Autocrine BDNF–TrkB signalling within a single dendritic spine - Nature
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In vivo imaging demonstrates dendritic spine stabilization by SynCAM 1 - Nature
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Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation - Nature
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Neural Cell Adhesion Molecule NrCAM Regulates Semaphorin 3F-Induced Dendritic Spine Remodeling - Journal of Neuroscience
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Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning - Nature
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Bidirectional in vivo structural dendritic spine plasticity revealed by two-photon glutamate uncaging in the mouse neocortex - Nature
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Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens - PNAS
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VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation - Nature
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Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine - Nature
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Maintenance of Dendritic Spine Morphology by Partitioning-Defective 1b through Regulation of Microtubule Growth - Journal of Neuroscience
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Dendritic spine formation and synaptic function require neurobeachin - Nature
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Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex - PNAS
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Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation - PNAS
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Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease - Journal of Neuroscience
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The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia - Nature
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Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice - Nature
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Rapid Reversible Changes in Dendritic Spine Structure In Vivo Gated by the Degree of Ischemia - Journal of Neuroscience
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PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage - Nature
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Dendritic spine changes associated with hippocampal long-term synaptic plasticity - Nature
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The dendritic spine story: an intriguing process of discovery - Frontiers
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Fear conditioning and extinction induce opposing changes in dendritic spine remodeling and somatic activity of layer 5 pyramidal neurons in the mouse motor cortex - Nature
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Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling | Stroke - American Heart Association Journals
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Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood - Frontiers
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Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis - Journal of Neuroscience
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Long-term dendritic spine stability in the adult cortex - Nature
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Regulation of Dendritic Spine Morphogenesis by Insulin Receptor Substrate 53, a Downstream Effector of Rac1 and Cdc42 Small GTPases - Journal of Neuroscience
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Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons - Journal of Neuroscience
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Brain Pathology | ISN Neuropathology Journal - Wiley Online Library
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Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway | Translational Psychiatry - Nature
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Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy - Journal of Neuroscience
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The phospholipid-binding protein SESTD1 negatively regulates dendritic spine density by interfering with Rac1-Trio8 signaling pathway - Nature
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Reversal of long-term dendritic spine alterations in Alzheimer disease models - PNAS
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.