Why is "Cytosine" trending?

Search Interest Perspective

• Structural basis for double-stranded DNA cytosine deamination by BaDTF3 and its application in mitochondrial genome editing - Nature
• Triple Base Editor Diversifies Three Nucleotides at Once - CRISPR Medicine News
• Cells lose 20,000 individual DNA letters every single day, and scientists just filmed the enzyme that hunts them down - Earth.com
• Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition - Nature
• Are i‐Motif Structures in DNA Compatible with Cytosine–Ag(I)–Cytosine Base Pairs? - Wiley Online Library
• Sequencing method gets genetic and epigenetic information from the same molecule - Chemical & Engineering News
• All DNA/RNA Nucleobases Are Found On Asteroid Ryugu - Astrobiology Web
• Dual cytosine modification through hydroxylation and arabinofuranosylation in phages - Nature
• High-efficiency TadA cytosine base editors for precise modelling of human disease variants - Nature
• R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers - Nature
• A bacterial defense system targeting modified cytosine of phage genomic DNA - Nature
• Computational design of a high-precision mitochondrial DNA cytosine base editor - Nature
• PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development - Nature
• Noncanonical target-strand cytosine base editing via engineered Un1Cas12f1 platform - Nature
• An engineered yeast cytosine deaminase with improved catalytic activity and stability for macrophage-mediated enzyme/prodrug therapy - Nature
• UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors - Nature
• Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA - Nature
• An unnatural base pair for the detection of epigenetic cytosine modifications in DNA - Nature
• Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity - Nature
• Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity - Nature
• High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase - Nature
• Cytosine base editing systems with minimized off-target effect and molecular size - Nature
• A universal and wide-range cytosine base editor via domain-inlaid and fidelity-optimized CRISPR-FrCas9 - Nature
• Engineered Sdd7 cytosine base editors with enhanced specificity - Nature
• Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens - Nature
• Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish - Nature
• Improved cytosine base editors generated from TadA variants - Nature
• Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors - Nature
• Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs - Nature
• Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA - Nature
• Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference - Nature
• Sequence-specific prediction of the efficiencies of adenine and cytosine base editors - Nature
• Efficient CRISPR-Cas9 based cytosine base editors for phytopathogenic bacteria - Nature
• Adenine base editors catalyze cytosine conversions in human cells - Nature
• Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos - Science | AAAS
• Precision genome editing using cytosine and adenine base editors in mammalian cells - Nature
• Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability - Nature
• Asteroid Reveals The 5 Key Genetic Ingredients For Life on Earth - ScienceAlert
• Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation - Nature
• Detecting DNA cytosine methylation using nanopore sequencing - Nature
• Engineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces - Nature
• TadA orthologs enable both cytosine and adenine editing of base editors - Nature
• Genome-wide detection of cytosine methylations in plant from Nanopore data using deep learning - Nature
• Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice - Science | AAAS
• Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice - Nature
• Recurrent acquisition of cytosine methyltransferases into eukaryotic retrotransposons - Nature
• Targeting fidelity of adenine and cytosine base editors in mouse embryos - Nature
• Exploring changes in social spider DNA methylation profiles in all cytosine contexts following infection - Nature
• Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3 - Nature
• The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145 - Nature
• Impact of cytosine methylation on DNA binding specificities of human transcription factors - Science | AAAS
• Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing - Nature
• The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing - Science | AAAS
• Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency - Nature
• Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine - Nature
• DNA cytosine deamination is associated with recurrent Somatic Copy Number Alterations in stomach adenocarcinoma - Frontiers
• A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects - Nature
• DNA Methylation, Gene Expression, and Human Health - the-scientist.com
• Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease - Science | AAAS
• A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing - Nature
• Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses - Nature
• Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos - Nature
• Diversity of cytosine methylation across the fungal tree of life - Nature
• Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing - Nature
• Methods for detection of cytosine and thymine modifications in DNA - Nature
• A Hydrophilic Interaction Chromatography Method for the Purity Analysis of Cytosine - Chromatography Online
• Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging - Nature
• High-Fidelity Cytosine Base Editing in a GC-Rich Corynebacterium glutamicum with Reduced DNA Off-Target Editing Effects - ASM Journals
• Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease - Nature
• A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase - PNAS
• A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa - PNAS
• Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history - PNAS
• Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells - Nature
• Identification of a DNA-cytosine methyltransferase that impacts global transcription to promote group B streptococcal vaginal colonization - ASM Journals
• Cytosine and adenine deaminase base-editors induce broad and nonspecific changes in gene expression and splicing - Nature
• Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B - Nature
• Getting a hold on cytosine methylation in mRNA - Nature
• The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS - Nature
• Prebiotic cytosine synthesis: A critical analysis and implications for the origin of life - PNAS
• Interactions with Single Cytosine-, Methylcytosine- and Hydroxymethylcytosine-Cytosine Mismatches in a Nanopore - Nature
• The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis - Nature
• Fluorescent RNA cytosine analogue – an internal probe for detailed structure and dynamics investigations - Nature
• Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases - Nature
• Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage - PNAS
• Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences - PNAS
• Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors - Nature
• UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization - Nature
• Identification of direct targets and modified bases of RNA cytosine methyltransferases - Nature
• Missing for partnership: understanding nucleosomal de novo DNA cytosine methylation by a spliced DNMT3 complex - Nature
• In vivo stabilization of the Dnmt1 (cytosine-5)- methyltransferase protein - PNAS
• The effects of cytosine methylation on general transcription factors - Nature
• Epigenetic switch reveals CRISPR/Cas9 response to cytosine methylation in plants - Wiley & Sons
• Genomics of DNA cytosine methylation in Escherichia coli reveals its role in stationary phase transcription - Nature
• Enhanced Cytosine Base Editing for Duchenne Muscular Dystrophy - CRISPR Medicine News
• Identification and gene expression analysis of cytosine-5 DNA methyltransferase and demethylase genes in Amaranthus cruentus L. under heavy metal stress - Frontiers
• Explainer: What Are Base Editors and How Do They Work? - CRISPR Medicine News
• Inheritance of directed DNA cytosine methylation in mammals - Nature
• Improved Dual Base Editor Systems (iACBEs) for Simultaneous Conversion of Adenine and Cytosine in the Bacterium Escherichia coli - ASM Journals
• Density functional theory studies on cytosine analogues for inducing double-proton transfer with guanine - Nature
• CRISPR editors gain precision via evolved hotspots - CRISPR Medicine News