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Cytokeratin 5/6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6. These are used in immunohistochemistry, often called CK 5/6 staining, including the following applications:Identifying basal cells or myoepithelial cells in the breast and prostate.
For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions from ductal carcinoma in situ, which is usually negative. Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma or papillary carcinoma.
In the lung, distinguishing epithelioid mesothelioma from lung adenocarcinoma.
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