Why is "Cytochrome P450" trending?

Search Interest Perspective

• Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins - Nature
• The impact of the exposome on cytochrome P450-mediated drug metabolism - Frontiers
• An assessment of the cytochrome P450 2-hydroxyisoflavanone synthase (2-HIS) crystal structure - Nature
• Enhancing cross-organelle coordination to advance plant cytochrome P450 functionality in yeast - Science | AAAS
• Pharmacogenomics of Cytochrome P450 of Nimodipine... : Journal of Neuroscience Nursing - Ovid
• GmCYP86A37 is a bifunctional cytochrome P450 essential for soybean root aliphatic suberin biosynthesis - Frontiers
• Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids - Nature
• Characterization and Functional Analysis of Three Cytochrome P450 Monooxygenases in Lasioderma serricorne: Assessing Their Contribution to Lambda‐Cyhalothrin Susceptibility Through RNA Interference - Wiley Online Library
• Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments - Frontiers
• Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria - Nature
• Four Cytochrome P450 Enzymes Mediate Oxidation Cascades in the Biosynthesis of Cephalotane-Type Diterpenoids - Wiley Online Library
• Estrogen Associations with Human Pregnancy Related Increases in Cytochrome P450 3A Activity - Frontiers
• Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism - Nature
• Side-Chain Macrocyclization in Ahp-Bicyclodepsipeptides Biosynthesis Involves Cytochrome P450-Catalyzed Sequential Aromatic Hydroxylation and C─N Coupling - Wiley Online Library
• A mismatch in enzyme-redox partnerships underlies divergent cytochrome P450 activities between human hepatocytes and microsomes | Communications Biology - Nature
• Designing cytochrome P450 enzymes for use in cancer gene therapy - Frontiers
• Unique electron transfer system of cytochrome P450 monooxygenase includes a mechanism of fatty acid β-oxidation - Nature
• Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis | Scientific Reports - Nature
• Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates - Nature
• Heterologous expression of high-activity cytochrome P450 in mammalian cells - Nature
• Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocyclases - ACS Publications
• Tissue-preferential recruitment of electron transfer chains for cytochrome P450-catalyzed phenolic biosynthesis - Science | AAAS
• Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase - Nature
• Label-free chemical imaging of cytochrome P450 activity by Raman microscopy - Nature
• Synthesis of mono Cytochrome P450 in a modified CHO-CPR cell-free protein production platform - Nature
• The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data - Nature
• Reductive Cytochrome P450 Reactions and Their Potential Role in Bioremediation - Frontiers
• Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems - Nature
• Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids - Nature
• Cyprocide selectively kills nematodes via cytochrome P450 bioactivation - Nature
• Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles - Nature
• Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model - Science Partner Journals
• Comparative study of cytochrome P450 expression in the kidneys of Lepus yarkandensis and Oryctolagus cuniculus - Nature
• Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma - Nature
• Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid - Nature
• Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish - Nature
• Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli - Wiley & Sons
• Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants - Nature
• Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis - PNAS
• The scaffold proteins of lignin biosynthetic cytochrome P450 enzymes - Nature
• Engineering of a functional human NADH-dependent cytochrome P450 system - PNAS
• The Effect of Force-Field Parameters on Cytochrome P450-Membrane Interactions: Structure and Dynamics - Nature
• A promiscuous cytochrome P450 aromatic O -demethylase for lignin bioconversion - Nature
• Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans - Nature
• Cytochrome P450 inhibition potential and initial genotoxic evaluation of 14-O-[(4,6-diaminopyrimidine-2-yl)thioacetyl] mutilin - Nature
• Glimpsing the Critical Intermediate in Cytochrome P450 Oxidations - Science | AAAS
• Bacterial Cytochrome P450 Catalyzed Post-translational Macrocyclization of Ribosomal Peptides - Wiley Online Library
• Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution - Nature
• Mobility of cytochrome P450 in the endoplasmic reticulum membrane - PNAS
• Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes - Nature
• Cytochrome P450-2D6 activity in people with codeine use disorder - Nature
• Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer - Nature
• Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling - Nature
• Structural Insights on the Conversion of Cytochrome P450 to P420 - ACS Publications
• HepaRG Cells as an in Vitro Model for Evaluation of Cytochrome P450 Induction in Humans - ScienceDirect.com
• Coupling of Redox and Structural States in Cytochrome P450 Reductase Studied by Molecular Dynamics Simulation - Nature
• Discovery and Biosynthesis of Cihanmycins Reveal Cytochrome P450-Catalyzed Intramolecular C–O Phenol Coupling Reactions - ACS Publications
• Epigenetic alterations in cytochrome P450 oxidoreductase ( Por ) in sperm of rats exposed to tetrahydrocannabinol (THC) - Nature
• Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis - Nature
• Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks - PNAS
• Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle - Nature
• Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice - Nature
• Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities - Nature
• X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative - PNAS
• Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis - Nature
• Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength - Nature
• Spontaneous Ligand Access Events to Membrane-Bound Cytochrome P450 2D6 Sampled at Atomic Resolution - Nature
• An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution - PNAS
• Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase - Nature
• CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata - PNAS
• Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study - Nature
• Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients - Nature
• Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae - PNAS
• Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4 - Nature
• Inhibition of cytochrome P450 3A by acetoxylated analogues of resveratrol in in vitro and in silico models - Nature
• Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s - Nature
• Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis - Nature
• Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis - Nature
• Pharmacokinetics of midazolam and hepatic cytochrome P450 3A activity in an in vivo extracorporeal membrane oxygenation rat model | Scientific Reports - Nature
• Insights into Cytochrome P450 Enzyme Catalyzed Defluorination of Aromatic Fluorides - Wiley Online Library
• Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis - Nature
• Cytochrome P450 and flavin-containing monooxygenase families: age-dependent differences in expression and functional activity - Nature
• Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases - Nature
• Pungent ginger components modulates human cytochrome P450 enzymes in vitro - Nature
• Cytochrome P450-Dependent Eicosapentaenoic Acid Metabolites Are Novel BK Channel Activators - American Heart Association Journals
• Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants - Frontiers
• Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate - PNAS
• HepaRG Cells as an in Vitro Model for Evaluation of Cytochrome P450 Induction in Humans - ScienceDirect.com
• Molecular determinant of substrate binding and specificity of cytochrome P450 2J2 - Nature
• Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization | Scientific Reports - Nature
• Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism - Nature
• Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly( N -isopropylacrylamide)-based temperature-responsive chromatography - Nature
• A Cytochrome P450 TxtE Model System with Mechanistic and Theoretical Evidence for a Heme Peroxynitrite Active Species - Mondal - 2024 - Angewandte Chemie International Edition - Wiley Online Library
• Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase - PNAS
• Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis - Wiley Online Library
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain - PNAS
• Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors | Scientific Reports - Nature
• Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors - PNAS
• Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl-Substituted Aromatic Polyketides - Wiley Online Library
• Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti-Tumor Agent - Wiley & Sons