Why is "Cyclooxygenase" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-25 03:50:44
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Cyclooxygenase entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-25 and was most recently seen on 2026-04-25.
Wikipedia Overview
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1) that is responsible for biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. The specific reaction catalyzed is the conversion from arachidonic acid to prostaglandin H2 via a short-lived prostaglandin G2 intermediate.
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Trending Topic Today
Search Interest Perspective
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Spin-driven enantioselective regulation of cyclooxygenase-2 activity for rheumatoid arthritis therapy via chiral gold nanohelices - Nature
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Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response - American Heart Association Journals
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Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin - nejm.org
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Cyclooxygenase-2 as a therapeutic target against human breast cancer: A comprehensive review - Wiley Interdisciplinary Reviews
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Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis - Frontiers
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Cyclooxygenase 2: protein-protein interactions and posttranslational modifications - American Physiological Society Journal
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PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation - Journal of Nuclear Medicine
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Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate - PNAS
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Therapeutic efficacy of Rosa damascena Mill. on oxidative stress parameters and cyclooxygenase-2 gene expression in estradiol valerate-induced polycystic ovarian syndrome in Wistar rats - Nature
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Biology of cyclooxygenase-2: An application in depression therapeutics - Frontiers
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Cyclooxygenase‐2 in gastrointestinal malignancies - Wiley & Sons
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Three-dimensional structure of human cyclooxygenase (hCOX)-1 - Scientific Reports - Nature
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Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice - Nature
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Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype - Nature
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In situ click chemistry generation of cyclooxygenase-2 inhibitors - Nature
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Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways - Nature
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Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor - Nature
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Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence - Nature
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Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming - Nature
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Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants - Nature
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Signature profile of cyclooxygenase-independent F2 series prostaglandins in C elegans and their role in sperm motility - Nature
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The cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts - Nature
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Cyclooxygenase-2 Inhibitor: A Potential Combination Strategy With Immunotherapy in Cancer - Frontiers
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Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1 - Nature
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Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer - Nature
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Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity - Science | AAAS
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Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2 - Science | AAAS
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Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization | Scientific Reports - Nature
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The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans - Nature
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inhalation promotes Alzheimer’s disease-like progression: cyclooxygenase-2-derived prostaglandin E - Nature
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Cyclooxygenases, the Kidney, and Hypertension - American Heart Association Journals
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Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice - Nature
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Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults - American Heart Association Journals
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Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia - PNAS
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Cyclooxygenase-2 Inhibitors | Stroke - American Heart Association Journals
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Renal Identification of Cyclooxygenase-2 in a Subset of Thick Ascending Limb Cells - American Heart Association Journals
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Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum? - PNAS
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C]PS13 Demonstrates Pharmacologically Selective and Substantial Binding to Cyclooxygenase-1 in the Human Brain - Journal of Nuclear Medicine
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PET measurement of cyclooxygenase-2 (COX-2) with 11C-MC1 in healthy human brain - Journal of Nuclear Medicine
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miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PGE2 in the amnion during pregnancy and labor - Nature
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Positron Emission Tomography Quantification in Healthy Humans of Cyclooxygenase-2 (COX-2), a Potential Biomarker of Neuroinflammation - Journal of Nuclear Medicine
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Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90 - Science | AAAS
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Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia - Journal of Nuclear Medicine
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Nonsteroidal anti-inflammatory drugs and implications for the cyclooxygenase pathway in embryonic development - American Physiological Society Journal
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Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics - Nature
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Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs - PNAS
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Cyclooxygenase-2 induced β1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway - Nature
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Cyclooxygenase-2 Activity Following Traumatic Brain Injury in the Developing Rat - Nature
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Isoform-Specific Compensation of Cyclooxygenase ( Ptgs ) Genes during Implantation and Late-Stage Pregnancy - Nature
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An Activity‐Based Sensing Approach for the Detection of Cyclooxygenase‐2 in Live Cells - Wiley Online Library
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[11C]PS13 PET shows that age is positively correlated with constitutively expressed cyclooxygenase-1 in the brain - Journal of Nuclear Medicine
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RETRACTED ARTICLE: The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage - Nature
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Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation - Frontiers
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Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression - PNAS
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Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway - American Heart Association Journals
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foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress - Nature
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Cyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents - Nature
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Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo - Frontiers
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Inducible cyclooxygenase may have anti-inflammatory properties - Nature
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A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients - Nature
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Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway - Nature
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Cyclooxygenase-2 Expression and Role of Vasoconstrictor Prostanoids in Small Mesenteric Arteries From Patients With Crohn’s Disease - American Heart Association Journals
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Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice - Nature
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Mechanism for the reactivation of the peroxidase activity of human cyclooxygenases: investigation using phenol as a reducing cosubstrate - Nature
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Nociception in cyclooxygenase isozyme-deficient mice - PNAS
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11C-MC1 has adequate sensitivity to measure low density cyclooxygenase 2 (COX-2) in healthy human brain - Journal of Nuclear Medicine
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The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway - Nature
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Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance | Scientific Reports - Nature
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The hyperthermic effect of central cholecystokinin is mediated by the cyclooxygenase-2 pathway - American Physiological Society Journal
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Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea - Nature
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Constitutive Spinal Cyclooxygenase-2 Participates in the Initiation of Tissue Injury-Induced Hyperalgesia - Journal of Neuroscience
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Induction of Cyclooxygenase-2 Accounts for Restraint Stress-Induced Oxidative Status in Rat Brain - Nature
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F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation - Journal of Nuclear Medicine
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Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis - PNAS
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Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor - ASM Journals
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Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen - Nature
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K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions - Nature
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Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Endothelial Function in Salt-Induced Hypertension - American Heart Association Journals
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Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity - Frontiers
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Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer - Nature
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Effects of acute selective cyclooxygenase-2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance - Wiley & Sons
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Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2 - Science | AAAS
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The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis - nejm.org
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Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation - Science | AAAS
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Correction: Cyclooxygenase pathway mediates the inhibition of Na-glutamine co-transporter B0AT1 in rabbit villus cells during chronic intestinal inflammation | PLOS One - PLOS
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Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms - American Heart Association Journals
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Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability - Nature
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Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance - PNAS
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Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc - Nature
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Differential Impact In Vivo of Pf4-ΔCre–Mediated and Gp1ba-ΔCre–Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice - American Heart Association Journals
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Inhibition of cyclooxygenase activity blocks cell-to-cell spread of human cytomegalovirus - PNAS
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Electrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activity - Wiley & Sons
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Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells - Nature
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Pituitary adenylate cyclase-activating polypeptide mediates bacterial endotoxin-induced fever via an effect on cyclooxygenase-2 and inflammatory cytokines - Nature
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Medicaid Prior-Authorization Programs and the Use of Cyclooxygenase-2 Inhibitors - nejm.org
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Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs - PNAS
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Selective Cyclooxygenase-2 Inhibitors Development in Cardiovascular Medicine - American Heart Association Journals
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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 - Nature
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Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression - Nature
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Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.