Why is "Constitutive activation" trending?

Search Interest Perspective

• The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders | Blood Cancer Journal - Nature
• Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons - Journal of Neuroscience
• Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome - NEJM
• Constitutive activation of tethered-peptide/ corticotropin-releasing factor receptor chimeras - PNAS
• Constitutive activation of ABA receptors in Arabidopsis reveals unique regulatory circuitries - nph.onlinelibrary.wiley.com
• Constitutive activation mechanism of a class C GPCR - Nature
• Constitutive Activation Drives Compartment-Selective Endocytosis and Axonal Targeting of Type 1 Cannabinoid Receptors - Journal of Neuroscience
• Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo - PNAS
• Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2 - Nature
• Exploring the constitutive activation mechanism of the class A orphan GPR20 - Nature
• Constitutive activation of two-component systems reveals regulatory network interactions in Streptococcus agalactiae - Nature
• Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate - Nature
• Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation - Nature
• Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors - Nature
• GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 - Nature
• Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer - Nature
• Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists - Nature
• Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice - Nature
• Constitutive activation of CREB in mice enhances temporal association learning and increases hippocampal CA1 neuronal spine density and complexity - Nature
• Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth | Nature Chemical Biology - Nature
• Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome - NEJM
• EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells - PNAS
• Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo | Oncogenesis - Nature
• Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders - Nature
• Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis - Nature
• Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma - Nature
• Constitutive activation of a nuclear-localized calcium channel complex in Medicago truncatula - PNAS
• Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer - Nature
• Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway | Oncogene - Nature
• Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer - Nature
• Constitutive Activation of Gαs within Forebrain Neurons Causes Deficits in Sensorimotor Gating Because of PKA-Dependent Decreases in cAMP | Neuropsychopharmacology - Nature
• Constitutive activation of the Wnt/ β -catenin signalling pathway in acute myeloid leukaemia - Nature
• Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts - Nature
• Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain - Nature
• Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells - Nature
• Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice - Nature
• Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation - Nature
• Constitutive activation of NF-κB in Ki- ras -transformed prostate epithelial cells - Nature
• Constitutive activation of nuclear factor-κB prevents TRAIL-induced apoptosis in renal cancer cells - Nature
• Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen | Oncogene - Nature
• Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors - Nature