Why is "Complement system" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-04 18:49:31
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Complement_system entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-04 and was most recently seen on 2026-06-04.
Wikipedia Overview
The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. Despite being part of the innate immune system, the complement system can be recruited and brought into action by antibodies generated by the adaptive immune system.
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Trending Topic Today
Search Interest Perspective
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Clinical Application of the Complement System - Cleveland Clinic
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The role of the complement system in gastrointestinal-related diseases - frontiersin.org
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A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice - Nature
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Decoding the Complement System: Cloud‑Clone One‑Stop Solutions for Advanced Complement Research - The National Law Review
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Is complement therapy the path forward for geographic atrophy? | Eye Care Network - Modern Retina - Ophthalmology Times
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The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs - Wiley Online Library
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Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis - Nature
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A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome” - frontiersin.org
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Complement System - British Society for Immunology
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Hidden rare mutations may help explain mystery cases of aHUS - aHUS News
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Complement diagnostics for eye and kidney diseases | SciFiMed Project | Results in Brief | H2020 - cordis.europa.eu
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C3 Glomerulopathy Treatment Breakthrough Found in Complement Inhibitor - Genetic Engineering and Biotechnology News
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Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort - Nature
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The inner fire: the shifting paradigm of complement system in aging - frontiersin.org
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Complement system in tumor growth and metastases - Nature
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Complement and inflammasome crosstalk in chronic inflammation - frontiersin.org
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Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D - Nature
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SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion | Scientific Reports - Nature
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The contribution of the membrane-bound complement regulatory proteins CD46 and CD55 in phases of acute lymphocytic leukemia and acute myelogenous leukemia - Nature
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Complosome — the intracellular complement system - Nature
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The complement system in schizophrenia: where are we now and what’s next? - Nature
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Role of Complement System in Kidney Transplantation: Stepping From Animal Models to Clinical Application - frontiersin.org
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Microbial evasion of the complement system: a continuous and evolving story - frontiersin.org
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Thinking inside the box: intracellular roles for complement system proteins come into focus - Nature
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Activation of platelets and the complement system in mice with Schistosoma -induced pulmonary hypertension - American Physiological Society Journal
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The complement system in neurodegenerative and inflammatory diseases of the central nervous system - frontiersin.org
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Biomaterial design for proactive modulation of the complement system - Nature
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Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics - frontiersin.org
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Modulation of the Complement System by Neoplastic Disease of the Central Nervous System - frontiersin.org
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Impact of smoking on the complement system: a narrative review - frontiersin.org
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The Complement System in Dialysis: A Forgotten Story? - frontiersin.org
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Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia - Nature
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Editorial: New insights into the role of complement system in liver diseases - frontiersin.org
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Activation of the ‘complement system’ helps trigger dangerous sickle-cell-disease outcome - C&EN
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The Complement System: A Prey of Trypanosoma cruzi - frontiersin.org
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Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens - frontiersin.org
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Complement and its role in innate and adaptive immune responses - Cell Research - Nature
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Complement System: An Immunotherapy Target in Colorectal Cancer - frontiersin.org
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Divergent complement system activation in two clinically distinct murine models of multiple sclerosis - frontiersin.org
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Activation of the complement system generates antibacterial peptides - PNAS
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Multi‐omics analysis reveals the interaction between the complement system and the coagulation cascade in the development of endometriosis - Nature
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Complement System in Dermatological Diseases – Fire Under the Skin - frontiersin.org
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Novo Nordisk Gets New Complement System Approach to Rare Diseases With Deal for Omeros Drug - MedCity News
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The complement system as a target in cancer immunotherapy - Merle - 2024 - European Journal of Immunology - Wiley Online Library
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HIV-1 subverts the complement system in semen to enhance viral transmission - Nature
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The state of complement in COVID-19 - Nature
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Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads - frontiersin.org
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Editorial: Updates on the complement system in kidney diseases - frontiersin.org
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The Complement System in Metabolic-Associated Kidney Diseases - frontiersin.org
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Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway - Nature
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The role of the complement system in primary membranous nephropathy: A narrative review in the era of new therapeutic targets - frontiersin.org
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Complement System in Brain Architecture and Neurodevelopmental Disorders - frontiersin.org
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Kulkarni recognized for research into complement system - WashU Medicine
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Increased complement system activation linked to antibodies... - myastheniagravisnews.com
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The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs - frontiersin.org
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Mini Med School: Understanding the Complement System With PNH - healthcentral.com
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Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus - Nature
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CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system | Gene Therapy - Nature
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Granzyme K identified as key trigger of complement system in autoimmune diseases - News-Medical
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Could Q32 Bio’s ‘Skeleton Key’ Open the Door to New Treatments for an Array of Diseases? - University of Colorado Anschutz
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The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis - Nature
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Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade - Nature
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Mast cells and complement system: Ancient interactions between components of innate immunity - Wiley Online Library
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Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system - Nature
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NIH to Fund Study Exploring Role of the Complement System in Chemotherapy-Induced Peripheral Neuropathy - Cleveland Clinic
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Novel evidence for complement system activation in chick myopia and hyperopia models: a meta-analysis of transcriptome datasets - Nature
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The complement system in sclera. - ARVO Journals
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Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System - Nature
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The complement system and age-related macular degeneration - Nature
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Interactions Between Pathogenic Burkholderia and the Complement System: A Review of Potential Immune Evasion Mechanisms - frontiersin.org
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The potential role of complement in cardiac surgery-associated acute kidney injury - Nature
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The role of complement in tumor immune tolerance and drug resistance: a double-edged sword - frontiersin.org
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BPS Publications - British Pharmacological Society | Journals
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Mechanisms of Disease: the complement system in renal injury—new ways of looking at an old foe - Nature
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Complement System Overactive in AAV Patients With Active Disease, Study Finds - ANCA Vasculitis News
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Dynamic control of the complement system by modulated expression of regulatory proteins - Nature
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The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1 - Journal of Neuroscience
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Understanding the Critical and Emerging Role of Complement in Neurological Disorders - NeurologyLive
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The complement system: The driving force behind a new generation of immunotherapies - pharmaphorum
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Complement system appears to be specifically implicated in severe COVID-19 - News-Medical
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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation - Nature
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Complement System Dysregulation and Oxidative Stress in the abca4-/- Mice - ARVO Journals
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The role of the complement system in infectious disease: Expert opinion on future diagnostic and therapeutic potentials - SelectScience
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Feb 20: Unraveling the interaction between Klebsiella pneumoniae, antibodies and the complement system - UMC Utrecht
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The importance of investigating complement system in gene therapy - SelectScience
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Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System - frontiersin.org
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Complement system shown to remove dead cells in retinitis pigmentosa, contradicting previous research - News-Medical
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Trypanosoma cruzi Evades the Complement System as an Efficient Strategy to Survive in the Mammalian Host: The Specific Roles of Host/Parasite Molecules and Trypanosoma cruzi Calreticulin - frontiersin.org
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Study finds blood changes in long-COVID patients - CIDRAP
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Editorial: Community series in the role of complement in health and disease, volume II - frontiersin.org
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The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation - Nature
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A great escape — how SARS-CoV-2 evades our defenses - American Society for Biochemistry and Molecular Biology
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Essential Role of Complement in Pregnancy: From Implantation to Parturition and Beyond - frontiersin.org
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The complement system in regulation of adaptive immunity - Nature
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The alternative complement pathway is dysregulated in patients with chronic heart failure - Nature
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Advances in assay of complement function and activation - ScienceDirect.com
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Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System - Wiley Online Library
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Clinical trial focuses on reducing overactive immune response in COVID-19 - WashU Medicine
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Intracellular complement and immunometabolism: The advantages of compartmentalization - Wiley Online Library
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Ascitic complement system in ovarian cancer - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.