Why is "Colistin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-06-30 04:04:15
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Colistin entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-06-30 and was most recently seen on 2026-06-30.
Wikipedia Overview
Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, carbapenem-resistant Klebsiella pneumoniae (CRKP), or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions, it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.
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Trending Topic Today
Search Interest Perspective
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Combinations of colistin and bacteriocins prevent the selection of colistin resistance in Acinetobacter baumannii - Nature
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Estimation of Colistin Resistance Among Multidrug-Resistant Gram-Negative Bacilli: An Observational Study - Cureus
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Exploring the anti-biofilm effect of darobactin B and colistin in static and dynamic environments - ASM Journals
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Minimum Inhibitory Concentration of Colistin Affects Outcomes in Gram-Negative Infections - Medscape
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Synergistic strategies to rescue the last-resort antibiotic colistin - Springer Nature Link
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Rising Colistin Resistance in Key Pathogens Signals Antimicrobial Treatment Concerns - Contagion Live
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Antibiotic Resistance and Biofilm Gene Distribution in Colistin-Resistant Acinetobacter baumannii - Wiley Online Library
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Colistin resistance plasmids dually enhance bacterial virulence and antibiotic resistance via surface polysaccharide biosynthesis - Nature
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Identification of Plasmid-Mediated Colistin Resistance in Multidrug-Resistant Gram-Negative Rods Isolated From Immunocompromised Patients - Cureus
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Siderophore sharing protects clonal Pseudomonas aeruginosa biofilms from colistin - ASM Journals
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Differential membrane lipid disruption by lipopeptide antibiotics, colistin and turnercyclamycins - Nature
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Emergence of Colistin Resistance in Multidrug-Resistant Escherichia coli and Klebsiella Species From Central India: A Sentinel Study With the Detection of mcr-1 From Blood Isolates - Cureus
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Targeting MCR-3 and membrane biosynthesis: mechanistic insights into pterostilbene-colistin synergy - ASM Journals
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Lipopolysaccharide clustering in colistin persistent and resistant bacteria - Nature
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Comparative genomics of colistin-nonsusceptible multidrug-resistant Pseudomonas aeruginosa reveals emerging lineages in Thailand - Nature
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Synergistic effects of colistin-based combinations against colistin and carbapenem-resistant Klebsiella pneumoniae isolated from nosocomial bloodstream infections - Nature
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Co-occurrence of mcr- 1 and mcr -3 mobilized colistin resistance genes among carbapenem-resistant Pseudomonas aeruginosa in Iran - Nature
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A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae - Nature
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in multidrug-resistant Escherichia coli isolates from calves in Iran - Nature
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Colistin adorned topical nanoemulsion gel formulation for enhanced anti-microbial activity - Nature
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Clinical and Microbiological Aspects of Colistin Resistance in Klebsiella pneumoniae Isolates From Tertiary-Care Hospital - Cureus
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Evaluation of Six Commercial and Noncommercial Colistin Resistance Diagnostics - Wiley Online Library
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Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung - ASM Journals
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Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations - ASM Journals
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Colistin- and cefotaxime-resistant Shiga toxin-producing Escherichia coli (STEC) in buffalo meat - Nature
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Niclosamide nanoparticles as a novel adjuvant reverse colistin resistance via multiple mechanisms against multidrug-resistant Salmonella infections - ASM Journals
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The Evaluation of Two Colistin Minimum Inhibitory Concentration (MIC) Methods: A Comparative Study of MicroScan Walkaway 96 Plus ID/AST and Colistin Broth Disc Elution Test at a Tertiary Care Hospital in Punjab - Cureus
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Molecular Characterization of Carbapenem and Colistin Resistance in Isolates Causing Urinary Tract Infections at an Outpatient Setting of a Tertiary Care Hospital - Cureus
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Delineating molecular mechanisms on the acquisition of in vitro- adapted colistin-resistant Klebsiella pneumoniae by transcriptomic analysis - ASM Journals
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Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin - ASM Journals
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Overcoming phage resistance: efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii - ASM Journals
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Comparison of Broth Disk Elution and Broth Microdilution Methods for Colistin Susceptibility Testing in Carbapenem-Resistant Enterobacteriaceae and Pseudomonas aeruginosa - Cureus
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Aztreonam-Avibactam Demonstrates Noninferior Cure Rates and Strong Safety Profile Compared With Meropenem/Colistin - Contagion Live
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Genomic Surveillance in a Low- or Middle-Income Country: Convergent Colistin Resistance in Epidemic Klebsiella pneumoniae (ST11, ST147) in Peshawar, Pakistan - EMJ
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Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter (ESKAPE) Pathogens and Colistin Resistance in Ventilator-Associated Pneumonia: A Prospective Cross-Sectional - Cureus
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Growing resistance to critical antibiotic raises alarm across Africa, finds study - Down To Earth
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Killing of colistin-resistant Aeromonas hydrophila by a synthetic peptide - ASM Journals
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Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China - ASM Journals
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Hope Against Resistance: In Vitro Activity of the Ceftazidime-Avibactam and Aztreonam Combination Against Colistin-Resistant Klebsiella pneumoniae - Cureus
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Analysis and comparison of adverse events of colistin administered by different routes based on the FAERS database - Nature
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Antimicrobial effect of benzbromarone combined with colistin against multidrug-resistant bacteria - Frontiers
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Colistin Monotherapy versus Combination Therapy for Carbapenem-Resistant Organisms - NEJM Evidence
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Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria - Nature
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Disrupting iron homeostasis can potentiate colistin activity and overcome colistin resistance mechanisms in Gram-Negative Bacteria - Nature
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Synergistic antibacterial activity of ceftazidime–avibactam in combination with colistin, gentamicin, amikacin, and fosfomycin against carbapenem-resistant Klebsiella pneumoniae | Scientific Reports - Nature
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Resolving colistin resistance and heteroresistance in Enterobacter species - Nature
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Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses - Nature
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Inhibiting fatty acid synthesis overcomes colistin resistance - Nature
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Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy - Nature
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Valnemulin restores colistin sensitivity against multidrug-resistant gram-negative pathogens - Nature
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Vitamin B6 resensitizes mcr -carrying Gram-negative bacteria to colistin - Nature
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Investigation of CTX-M Type Extended-Spectrum β-Lactamase, Carbapenem and Colistin Resistance in Enterobacterales Isolated From Dairy Cattle in Turkey - Wiley Online Library
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A link between pH homeostasis and colistin resistance in bacteria - Nature
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Study suggests colistin still being widely used in animal feed - CIDRAP
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Population pharmacokinetics of colistin sulfate in critically ill patients based on NONMEM - Nature
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The role of pmrCAB genes in colistin-resistant Acinetobacter baumannii - Nature
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Can Colistin-Meropenem Synergy Improve Outcomes in Carbapenem-Resistant Infections? - Medscape
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Natural flavonoids disrupt bacterial iron homeostasis to potentiate colistin efficacy - Science | AAAS
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Resensitizing multidrug-resistant Gram-negative bacteria to carbapenems and colistin using disulfiram - Nature
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Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics - Nature
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Cost-effectiveness analysis of polymyxin B versus colistin for treating patients with carbapenem-resistant gram-negative bacterial infections - Nature
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Evidence of international transmission of mobile colistin resistant monophasic Salmonella Typhimurium ST34 - Nature
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Efficacy of loading dose colistin versus carbapenems for treatment of extended spectrum beta lactamase producing Enterobacteriaceae - Nature
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Rapid evolution of colistin resistance in a bioreactor model of infection of Klebsiella pneumoniae - Nature
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The global distribution and spread of the mobilized colistin resistance gene mcr-1 - Nature
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Penfluridol synergizes with colistin to reverse colistin resistance in Gram-negative bacilli - Nature
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Detection of mobile colistin resistance genes mcr-9.1 and mcr-10.1 in Enterobacter asburiae from Ecuadorian children - ASM Journals
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Colistin-resistant Escherichia coli harboring mcr-1 in slaty-backed gull breeding in Northern Japan - ASM Journals
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Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin - Nature
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Investigation of CTX-M Type Extended-Spectrum β-Lactamase, Carbapenem and Colistin Resistance in Enterobacterales Isolated From Dairy Cattle in Turkey - Wiley Online Library
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A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital - Nature
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Colistin Breakpoints Redux – or, the Fun Don’t Stop, Yo! - American Society for Microbiology
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model - Nature
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Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria - Frontiers
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Prevalence and transmission risk of colistin and multidrug resistance in long-distance coastal aquaculture - Nature
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Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections - Nature
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Colistin exposure enhances expression of eptB in colistin-resistant Escherichia coli co-harboring mcr -1 - Nature
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Commercialized artemisinin derivatives combined with colistin protect against critical Gram-negative bacterial infection - Nature
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Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial - The Lancet
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Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment - Nature
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A prospective matched case-control study on the genomic epidemiology of colistin-resistant Enterobacterales from Dutch patients - Nature
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Amphiphilic mPEG-PLGA copolymer nanoparticles co-delivering colistin and niclosamide to treat colistin-resistant Gram-negative bacteria infections - Nature
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Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin–sulbactam combination therapy - Nature
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Transition of colistin dependence into colistin resistance in Acinetobacter baumannii - Nature
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L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice - Nature
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High abundance of the colistin resistance gene mcr-1 in chicken gut-bacteria in Bangladesh - Nature
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A quantitative method for determination of colistin E2 methanesulphonate in human plasma by - Nature
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A Klebsiella pneumoniae DedA family membrane protein is required for colistin resistance and for virulence in wax moth larvae - Nature
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Gulls as Sources of Environmental Contamination by Colistin-resistant Bacteria - Nature
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Restoring colistin sensitivity in colistin-resistant E. coli : Combinatorial use of MarR inhibitor with efflux pump inhibitor - Nature
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In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens - Nature
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Enhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii - Nature
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Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters - Nature
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Rapid Detection of Mobilized Colistin Resistance using a Nucleic Acid Based Lab-on-a-Chip Diagnostic System - Nature
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A Targeted Click-to-Release Activation of the Last-Resort Antibiotic Colistin Reduces its Renal Cell Toxicity - Wiley Online Library
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The Efficacy of Colistin Combined with Amikacin or Levofloxacin against Pseudomonas aeruginosa Biofilm Infection - ASM Journals
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The fatty acid synthesis gene fabY affects lipopolysaccharide synthesis and colistin susceptibility in Pseudomonas aeruginosa - ASM Journals
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Emergence and Transmission of Plasmid-Mediated Mobile Colistin Resistance Gene mcr-10 in Humans and Companion Animals - ASM Journals
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Heparin increases the antibiotic efficacy of colistin - Frontiers
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Colistin Resistance Among Multiple Sequence Types of Klebsiella pneumoniae Is Associated With Diverse Resistance Mechanisms: A Report From India - Frontiers
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.