Why is "Citrullination" trending?

Search Interest Perspective

• High-throughput chemical proteomics workflow for profiling protein citrullination dynamics - Nature
• Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting - Frontiers
• NLRP3 inflammasome promotes PAD2/PAD4 release and protein citrullination in rheumatoid arthritis - Nature
• The role of glycosaminoglycans in enhancing protein citrullination in rheumatoid arthritis - Lightsources.org
• How Citrullination of CAMP Contributes to IBD: A New Mechanism of Immune Dysfunction | Newswise - newswise.com
• Citrullination negatively regulates the functions of the p53 protein and opposes its ubiquitination and degradation - PNAS
• Citrullinated peptides as drug candidates for rheumatoid arthritis - Frontiers
• Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification - Nature
• Compartmentalized citrullination in Muller glial endfeet during retinal degeneration - PNAS
• Pathogenesis of Porphyromonas gingivalis peptidylarginine deiminase: from periodontal microenvironment to systemic diseases - Frontiers
• PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome - Nature
• Mapping benefit, risk, and opportunity in PAD4 inhibition - Frontiers
• Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis - Nature
• A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates - Nature
• Citrullination modulation stabilizes HIF-1α to promote tumour progression - Nature
• PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription - Nature
• Human cytomegalovirus-induced host protein citrullination is crucial for viral replication - Nature
• Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis - Nature
• Citrullination of glucokinase is linked to autoimmune diabetes - Nature
• A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis - Nature
• Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils - Nature
• Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D - Nature
• Citrullination facilitates cross-reactivity of rheumatoid factor with non-IgG1 Fc epitopes in rheumatoid arthritis - Nature
• Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization - Science | AAAS
• Joint inflammation related citrullination of functional arginines in extracellular proteins - Nature
• Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix - Nature
• Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation - Nature
• The impact of decreased left ventricular ejection fraction on neutrophil extracellular trap (NET) formation measured by citrullinated histone H3 (citH_3) concentration - Nature
• Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials - Nature
• Association of citrullination with the progression of aortic stenosis - Nature
• Progression on Citrullination of Proteins in Gastrointestinal Cancers - Frontiers
• Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease | Cellular & Molecular Immunology - Nature
• Citrullination regulates pluripotency and histone H1 binding to chromatin - Nature
• The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4 - Nature
• Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination - Nature
• Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice - Nature
• Site-specific incorporation of citrulline into proteins in mammalian cells - Nature
• Citrullination of NF-κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury - Wiley & Sons
• Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis - Nature
• GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver - Nature
• Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity - PNAS
• Neutrophils adopt different defense strategies depending on the stimulus - Agência FAPESP
• Increased histone citrullination in juvenile idiopathic arthritis - Frontiers
• A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis - Nature
• Induction of Citrullination during Pathological Retinal Gliosis - iovs.arvojournals.org
• Helicobacter pylori -induced citrullination linked to RA exacerbation - Nature
• A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination - Frontiers
• Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer - Nature
• The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles - Science | AAAS
• The structure, specificity and function of anti-citrullinated protein antibodies - Nature
• Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation - PNAS
• Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties - Nature
• Elevated levels of citrullinated fibrinogen in patients with cancer - Arfman - 2024 - eJHaem - onlinelibrary.wiley.com
• Protein Citrullination: A Proposed Mechanism for Pathology in Traumatic Brain Injury - Frontiers
• Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4 - Nature
• Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem-Like Cells in Ovarian Cancer - Wiley & Sons
• Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis - Nature
• Citrullination in Tumor Metastasis, Inside and Outside the Cells - Tomita - 2025 - Cancer Science - onlinelibrary.wiley.com
• Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes - Nature
• Citrullinated Fibrinogen Renders Clots Mechanically Less Stable, but Lysis-Resistant - American Heart Association Journals
• Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase - Nature
• Increased Citrullination of Histone H3 in Multiple Sclerosis Brain and Animal Models of Demyelination: A Role for Tumor Necrosis Factor-Induced Peptidylarginine Deiminase 4 Translocation - Journal of Neuroscience
• The emerging role of citrullination in gene control and therapeutic innovation - eurekalert.org
• Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells - Nature
• Lungs and citrullination - Nature
• Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury - American Heart Association Journals
• A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis - Rockefeller University Press
• Citrullination is linked to reduced Ca2+ sensitivity in hearts of a murine model of rheumatoid arthritis - onlinelibrary.wiley.com
• Citrullination unravels stem cells - Nature
• Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus - Nature
• Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis - Nature
• Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects - Frontiers
• Regulation of histone modification and chromatin structure by the p53–PADI4 pathway - Nature
• Insights into the role of PAD2-mediated histone citrullination in pancreatic cancer progression - eurekalert.org
• Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation - Nature
• NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis - Science | AAAS
• Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays - Nature
• Bunkers That Save Sight? UConn Researchers Take a Close Look - UConn Today
• Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder - Frontiers
• Periodontitis in RA—the citrullinated enolase connection - Nature
• Poking Holes in Rheumatoid Joints - Science | AAAS
• Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca - Nature
• Breaking tolerance: autoantibodies can target protein posttranslational modifications - ScienceDirect.com
• Extracellular vimentin amplifies inflammation: Perspectives for immune injury and therapeutics for periodontitis - Wiley & Sons
• The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis - Nature
• Comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis” - Science | AAAS
• How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model - Frontiers
• Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts - Nature
• Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape - Nature
• Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses - Nature
• AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway - Nature
• $3.1 million NIA grant to advance Sanders-Brown researcher’s groundbreaking dementia study - UKNow
• Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types - PNAS
• Biochemically altered myelin triggers autoimmune demyelination - PNAS
• NETosis as Source of Autoantigens in Rheumatoid Arthritis - Frontiers
• Autoantibodies, citrullinated histones and initiation of synovitis - Nature
• Gum disease and rheumatoid arthritis | GUMS AND JOINTS Project | Results in Brief | FP7 - CORDIS
• Peptidyl arginine deiminase 2 ( Padi2 ) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development - Nature
• Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities - Nature
• RETRACTED: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition - Rockefeller University Press